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排序方式: 共有10000条查询结果,搜索用时 15 毫秒
91.
Jorge MP Madjarof C Gois Ruiz AL Fernandes AT Ferreira Rodrigues RA de Oliveira Sousa IM Foglio MA de Carvalho JE 《Journal of ethnopharmacology》2008,118(3):361-366
ETHNOPHARMACOLOGICAL RELEVANCE: Arrabidaea chica Verlot. (Bignoniaceae), popularly known as Crajiru, has been traditionally used as wound healing agent. AIM OF THE STUDY: Investigate in vitro and in vivo healing properties of Arrabidaea chica leaves extract (AC). MATERIALS AND METHODS: AC was evaluated in vitro in fibroblast growth stimulation (0.25-250 microg/mL) and collagen production stimulation (250 microg/mL) assays. Allantoin (0.25-250 microg/mL) and vitamin C (25 microg/mL) were used as controls respectively. DPPH and Folin-Ciocalteau assays were used for antioxidant evaluation, using trolox (0.25-250 microg/mL) as reference antioxidant. To study wound healing properties in rats, AC (100mg/mL, 200 microL/wound/day) was topically administered during 10 days and wound area was evaluated every day. Allantoin (100mg/mL, 200 microL/wound/day) was used as standard drug. After treatment, wound sites were removed for histopathological analysis and total collagen determination. RESULTS: AC stimulated fibroblast growth in a concentration dependent way (EC50=30 microg/mL), increased in vitro collagen production and demonstrated moderate antioxidant capacity. In vivo, AC reduced wound size in 96%, whereas saline group showed only 36% wound healing. CONCLUSION: AC efficiency seems to involve fibroblast growing stimulus and collagen synthesis both in vitro and in vivo, beyond moderate scavenging activity, corroborating Crajiru folk use. 相似文献
92.
Denny C Zacharias ME Ruiz AL do Carmo E do Amaral M Bittrich V Kohn LK de Oliveira Sousa IM Rodrigues RA de Carvalho JE Foglio MA 《Phytotherapy research : PTR》2008,22(1):127-130
An activity-guided fractionation of Virola sebifera Aubl. methylene chloride-soluble fraction provided novel 3,5-dihydro-2-(1'-oxo-3'-hexadecenyl)-2-cyclohexen-1-one (3), two known lignans (1, 2) and dehydro hexadecanoyl resorcinol (4). Isolation and purification were conducted with the application of column chromatography and structures were assigned by spetral analysis (1D and 2D NMR, HREIMS). Compounds 1-4 were evaluated for cytotoxic activities against human tumour cell lines UACC62 (melanoma), MCF-7 (breast), NCI 460 (lung, non-small cells), OVCAR03 (ovarian), PC-03 (prostate), HT-29 (colon), 786-0 (renal) and NCI-ADR (breast expressing phenotype multiple drugs resistance) in vitro. The new polyketide (3) showed selectivity against human OVCAR03 and NCI-ADR cell lines, ranging from 2 to 4 microg/mL. 相似文献
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Mir O Albiges L Arkwright S Duboc D Massault PP Tenenbaum F Touzé E Menasché P Vacher-Lavenu MC Goldwasser F Alexandre J 《Gynecologic oncology》2007,106(3):622-625
BACKGROUND: Non-bacterial thrombotic endocarditis is a severe complication of cancer, rarely reported in gynecologic tumors. However, it can be inaugural and lead to complex diagnostic pathways. CASE: A 40-year-old woman presented with a stroke, related to an endocarditis. The valvular vegetation was surgically removed, and a malignant node was resected. A PET-scan led to the diagnosis of a myometrial tumor, which was found to be a primitive neuroectodermal tumor (PNET). The patient underwent total abdominal hysterectomy with bilateral salpingo-oophorectomy, and systemic chemotherapy which allowed a complete remission of tumoral and cardio-vascular symptoms. CONCLUSION: To our knowledge, this is the first case report of a PNET of the myometrium revealed by cardio-vascular symptoms. 相似文献
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Dr. Alexandre Favre 《Virchows Archiv : an international journal of pathology》1890,120(3):460-476
Ohne Zusammenfassung 相似文献
99.
Rennan Garcias Moreira Julia Maria SaraivaDuarte Alexandre Costa Pereira Martha SosaMacias Carlos GalavizHernandez Meddly Lesley Santolalla Wagner C. S. Magalhes Camila Zolini Thiago Peixoto Leal Zsolt Balzs Adrin Llerena Robert H. Gilman Jos Geraldo Mill Victor Borda Heinner Guio Timothy D. OConnor Eduardo TarazonaSantos Fernanda RodriguesSoares 《CTS Clinical and Translational Science》2022,15(6):1400
100.
David Andrew McNamee Alexandre G. Legros Daniel R. Krewski Gerald Wisenberg Frank S. Prato Alex W. Thomas 《International archives of occupational and environmental health》2009,82(8):919-933
The effects of exposure to extremely low frequency (ELF) electromagnetic fields (EMFs) on human cardiovascular parameters
remain undetermined. Epidemiological studies have utilized dosimetry estimations of employee workplace exposure using altered
heart rate variability (HRV) as predictive of certain cardiovascular pathologies. Laboratory studies have focused on macrocirculatory
indicators including heart rate, HRV and blood pressure. Few studies have been conducted on the response of the microcirculatory
system to EMF exposure. Attempts to replicate both epidemiological and laboratory studies have been mostly unsuccessful as
study design, small sample populations and confounding variables have hampered progress to date. Identification of these problems,
in the current context of international exposure guideline re-evaluation, is essential for future EMF studies. These studies
should address the possible deleterious health effects of EMFs as well as the detection and characterization of subtle physiological
changes they may induce. Recommendations for future work include investigating the macro- and microcirculatory relationship
and the use of laboratory geomagnetic shielding. 相似文献