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991.
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Alexandra Sabrina Kohl Schwartz Elvira Gross Kirsten Geraedts Martina Rauchfuss Monika Maria Wölfler Felix Häberlin Stephanie von Orelli Markus Eberhard Patrick Imesch Bruno Imthurn Brigitte Leeners 《Reproductive biomedicine online》2019,38(2):260-271
Research question
Conventional treatments are often associated with adverse effects and endometriosis pain symptoms may reoccur despite treatment. Consequently, many women use complementary health approaches (CHA) and home remedies (HR) to relieve their pain. The aim of this study was to examine the frequency and the subjectively perceived efficacy of CHA/HR use by women affected by endometriosis.Design
Retrospective evaluation using medical charts and a questionnaire. Women recruited in hospitals and in self-help groups were asked about the use of ‘topical heat’, ‘repose/relaxation’, ‘movement/massages’, ‘homeopathy/phytotherapy’, ‘acupuncture/traditional Chinese medicine (TCM)’ and ‘kinesiology/physiotherapy’.Results
From a total of 574 women with a confirmed diagnosis of endometriosis, 359 (62.5%) applied some form of CHA/HR. Women suffering from fatiguing disease symptoms more often selected alternative therapies (odds ratio [OR] 3.14, 95% confidence interval [CI] 1.39–7.11, P?=?0.006) compared with women without these characteristics. Furthermore, women dissatisfied with healthcare provided by their treating physician, more frequently (OR 2.30, 95% CI 1.19–4.45, P?=?0.013) chose the aforementioned alternative strategies.Conclusion
As conventional therapies may not be sufficiently effective, women's needs should be closely examined, and individual treatment options should be discussed and initiated by clinicians to provide the best comprehensive treatment possible for endometriosis. 相似文献993.
994.
Julia L. Boland Qin Zhou Madhuri Martin Margaret K. Callahan Jason Konner Roisin E. OCearbhaill Claire F. Friedman William Tew Vicky Makker Rachel N. Grisham Martee L. Hensley Nicholas Zecca Alexia E. Iasonos Alexandra Snyder David M. Hyman Paul Sabbatini Carol Aghajanian Karen A. Cadoo Dmitriy Zamarin 《Gynecologic oncology》2019,152(2):251-258
Objective
Delayed responses observed with immune checkpoint blockade (ICB) present a challenge for patients with peritoneal malignancies, who risk early symptomatic disease progression requiring treatment discontinuation. While efforts are ongoing to define the biomarkers of response, it is equally important to identify patients at risk for early discontinuation. We sought to investigate the timing of disease progression in epithelial ovarian cancer (EOC) patients treated with ICB and to identify pre-treatment clinical parameters associated with early discontinuation.Methods
Retrospective analysis was performed on EOC patients treated with ICB at MSKCC from January 2013 to May 2017. Cutoffs for early and very early discontinuation due to disease progression were defined at 12 and 8?weeks, respectively. Univariate and multivariate logistic regression models were built based on pre-treatment clinical variables.Results
Of 108 identified patients, 89 were included in the analysis. Forty-six (51.7%) patients discontinued therapy early, 30 of which (33.7%) discontinued therapy very early. Eight patients (9.0%) died within 12?weeks of ICB initiation from disease progression. In multivariate analyses, bulky peritoneal disease (p?=?0.009, OR: 4.94) and liver parenchymal metastases (p?=?0.001, OR: 8.08) were associated with early discontinuation. Liver parenchymal metastases (p?=?0.001, OR 6.64), and high neutrophil-to-lymphocyte ratio (p?=?0.021, OR: 3.54), were associated with very early discontinuation.Conclusions
Over 50% of EOC patients suffer disease progression requiring early discontinuation of ICB. Pre-treatment prognostic clinical characteristics may identify patients at highest risk for early discontinuation due to disease progression and warrant caution in using these agents in late line patients with advanced disease. 相似文献995.
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Sophie Rivaud-Pechoux Alexandra Dürr Bertrand Gaymard Garaldine Cancel Christoph J. Ploner Yves Agid Alexis Brice Charles Pierrot-Deseilligny 《Annals of neurology》1998,43(3):297-302
We compared horizontal eye movements (visually guided saccades, antisaccades, and smooth pursuit) in control subjects (n = 14) and patients with three forms of autosomal dominant cerebellar ataxias type I: spinocerebellar ataxias 1 and 2 (SCA1, n = 11; SCA2, n = 10) and SCA3/Machado-Joseph disease (MJD) (n = 16). In SCA1, saccade amplitude was significantly increased, resulting in hypermetria. The smooth pursuit gain was decreased. In SCA2, saccade velocity was markedly decreased. The percentage of errors in antisaccades was greatly increased and was significantly correlated with age at disease onset. In addition, a correlation between smooth pursuit gain and the number of trinucleotide repeats was found. In SCA3, gaze-evoked nystagmus was often present as was saccade hypometria and smooth pursuit gain was markedly decreased. Three major criteria, saccade amplitude, saccade velocity, and presence of gaze-evoked nystagmus, permitted the correct assignment of 90% of the SCA1, 90% of the SCA2, and 93% of the patients with SCA3 to their genetically confirmed patient group and, therefore, may help orient diagnose of SCA1, SCA2, and SCA3 at early clinical stages of the diseases. 相似文献
999.