Node-positive transcranial recurrent melanoma: is an aggressive resection warranted?

Locally advanced, node-positive recurrence of malignant melanoma is a harbinger of distant metastases and signifies poor prognosis. However, the clinical course may vary due to the unpredictable biology of malignant melanoma. The presented patient developed a recurrent melanoma of the scalp that eroded through the skull and involved regional lymph nodes with extracapsular extension. He was treated with wide local excision of the recurrence, bilateral posterolateral neck dissection, and immediate microvascular reconstruction followed by adjuvant radiation therapy. The patient remains free of disease at 12 years. This case illustrates that an aggressive resection should be considered for the operable patients with locally advanced recurrent melanoma to render them disease free surgically.     

The effect of nonsteroidal anti-inflammatory agents on spinal fusion

A large body of information suggests NSAIDS have a negative impact on the healing of bone. Although each clinical healing scenario presents a slightly different level of challenge, the healing of a posterolateral spinal fusion is one of the most difficult challenges in bony healing. Clinically, this results in a relatively high rate of nonunions using traditional fusion techniques. Spinal fusion models have confirmed NSAIDS have a definite inhibitory effect on healing of the fusion. Although data are limited, it appears this effect is most severe when NSAIDS are administered in the early postoperative period. Moreover, the effect may be worse with certain types initial inflammatory, subsequent reparative, and final remodeling phases. Because of the anti-inflammatory activity of NSAIDS, one might assume their effects would be worse when administered in the inflammatory phase. Indeed, the study by Riew et al suggests the inhibitory effects are more significant when NSAIDS are administered earlier following fusion. Other studies conducted with non-spinal models also suggest early administration of NSAIDS results in greater inhibition of bone formation (Goodman et al). Unfortunately, the length of the inflammatory phase in humans is not well known. This leaves the clinician unsure about the safe time to allow resumption of NSAID usage clinically. It appears likely NSAID use following a spinal fusion procedure will increase the rate of pseudarthrosis. The literature suggests that avoidance of NSAIDS in the postoperative period may avoid nonunion. Additionally, we propose that chronic NSAID usage should be addressed in a similar manner to cigarette smoking. While neither are absolute contraindications to elective spinal fusion, patients should be counseled to discontinue the use of NSAIDS in the peri- and postoperative period to maximize their chance for a successful fusion.     

Links Between Parenting and Core Beliefs: Preliminary Psychometric Validation of the Young Parenting Inventory

This study describes the psychometric validation of the young parenting inventory (YPI), and tested specific hypotheses regarding the link between one’s experience of their parent’s behaviors and the development of schema-level core beliefs. The YPI is a measure of perceived parenting experiences, hypothesized to represent the origins of negative core beliefs. This preliminary validation consisted of analyses of factor structure, internal consistency, test–retest reliability, and construct validity. A large non-clinical student sample (N = 422) completed the YPI, and a subset also completed the Young Schema Questionnaire-Short form (YSQ-S). Factor analyses demonstrated that a shorter version of the questionnaire (YPI-R) could be developed to represent coherent and meaningful perceptions of each parent. The YPI-R consists of nine scales. Each scale had good test–retest reliability and adequate internal consistency. Significant associations between the YPI-R scales and negative core beliefs (as measured by the YSQ-S) indicated partial construct validity. At this preliminary stage, it can be concluded that the YPI-R has an acceptable level of psychometric utility. However, the hypothesized parenting-negative core belief links were not all substantiated.     

The effect of insertion and photopolymerization techniques on microleakage of class V cavities--a quantitative evaluation

The aim of this in vitro study was to evaluate by spectrophotometry the influence of the incremental technique and progressive light curing in the microleakage of Class V cavities. Forty samples were prepared with class V cylindrical cavities on the buccal root surface of bovine incisive teeth and filled with composite resin (Z250). The samples were divided into four groups: I: cavity was bulk filled and the composite was light cured for 40 seconds; Group II: cavity was bulk filled and a 'soft-start" polymerization was used; Group III: cavity was filled with the incremental technique in two coats and light cured for 40 seconds; Group IV: cavity was filled with the incremental technique in two coats and light cured with "soft-start" polymerization. After the restoration, the specimens were thermally stressed for 3,000 cycles in bath at 5 +/- 2 degrees C and 55 +/- 2 degrees C, protected with nail enamel, colored with 2% methylene blue and cut into sections. These sections were triturated and the dye was recovered with PA ethanol and the supernatant was evaluated. The data were submitted to ANOVA and the results showed the following averages: bulk filled and conventional photopolymerization (I) 0.06075 microg/ml; bulk filled and progressive photopolymerization (II) 0.04030 microg/ml; incremental insertion and conventional photopolymerization (III) 0.04648 microg/ml; incremental insertion and progressive photopolymerization (IV) 0.04339 microg/ml. No significant statistic differences were observed among the mean values. The Degulux "soft-start" equipment probably emits too high initial light intensity to promote progressive photopolymerization.     

The effect of heat on tissue extensibility: a comparison of deep and superficial heating

OBJECTIVE: To compare the effects of deep heating (shortwave diathermy [SWD]) and superficial heating (hydrocollator packs) on tissue extensibility. DESIGN: A double-blind, repeated-measures study. Possible effects of sex and intervention order were controlled. SETTING: A clinical laboratory. PARTICIPANTS: Twenty-four subjects with no neurologic or musculoskeletal pathologies affecting their lower limbs. INTERVENTIONS: Three intervention conditions: deep heating (SWD), superficial heating (hot packs), and no heating were applied in preallocated order to each subject at least 36 hours apart. MAIN OUTCOME MEASURES: Ankle dorsiflexion in weight bearing was measured by using an inclinometer to ascertain changes in the extensibility of the calf muscles and associated soft tissues. RESULTS: Deep heating increased the range of ankle dorsiflexion by 1.8 degrees +/-1.9 degrees . The change in ankle dorsiflexion after superficial and no heating was 0.7 degrees +/-1.5 degrees and -0.1 degrees +/-1.0 degrees , respectively. CONCLUSIONS: Deep heating, in the absence of stretching, increases tissue extensibility more than superficial heating or no heating. Superficial heating is more effective than no heating, but the difference was not statistically significant.     

Biomechanical background and clinical observations of rotational malalignment in TKA: literature review and consequences

Malalignment, in particular femoral component malrotation, is a commonly accepted failure mode in total knee arthroplasty. The general objective of this paper is twofold: firstly, it accentuates clinical observations of the effects of rotational malalignment in total knee arthroplasty. Secondly, it discusses the relevant parameters of existing knee joint models with regards to rotational malalignment and its biomechanical background, thereby setting a basis for future studies. To summarise, when modelling malalignment in total knee arthroplasty, the following aspects should be considered: Friction between the implant components, ligamentous and capsular structures, deformable body to model the PE inlay, and an in vivo validation of the model. Because of the large variance in anthropometrical data between individuals, future knee joint models should also incorporate individual data.     

Comparison of diameter of ascending aorta in patients with severe aortic stenosis secondary to congenital versus degenerative versus rheumatic etiologies

Aortic root dilation has been previously reported to be associated with aortic stenosis (AS), but data to support this statement are scarce. The dimensions of the aortic root were measured at 4 levels (annulus, sinuses, sinotubular junction, and ascending aorta) in 88 patients (mean age 71.2+/-9.7 years; 56% men) with severe AS who underwent intraoperative transesophageal echocardiography immediately before aortic valve replacement. These patients were compared with 76 gender- and age-matched patients without AS who underwent transesophageal echocardiography for various indications. The etiology of aortic valve stenosis was degenerative in 62 (70.5%), bicuspid aortic valve (BAV) in 15 (17.0%), and rheumatic in 11 (12.5%). The ascending aorta was significantly wider in AS with various etiologies (BAV, rheumatic, degenerative) than in the controls (39+/-6.9, 35.0+/-4.2, 33.1+/-4.1, and 31.3+/-3.7 mm, respectively; p<0.001). The dimensions of the sinuses and sinotubular junction were significantly less in those with AS of degenerative etiology than in the controls (29.5+/-4.0 vs 32.5+/-4.3 mm and 23.6+/-3.0 vs 26.8+/-3.0 mm, respectively, p<0.001). The prevalence of a dilated aorta (>37 mm) was 3.9%, 13.1%, 36.4%, and 60% in the control group and AS patients with degenerative, rheumatic, and BAV etiology, respectively (p<0.0001). In conclusion, patients with severe AS due to BAV had significant dilation of the aortic root. Patients with degenerative and rheumatic etiology had less remarkable dilation compared with control group, and most values were within the normal range.     

Promoting informed choice: transforming health care to dispense knowledge for decision making

Ours is an era in which patients seek greater engagement in health care choices, increasing the demand for high-quality information about clinical options. Providing support for informed choice is not straightforward, however, because of challenges faced by clinicians, health systems, and consumers. Greater use of written or electronic tools can help to clarify choices for patients, but decision aids cannot replace the human element in facilitating informed choice. The ideal solution is to couple information with high-quality decision counseling to help patients understand the potential risks, benefits, and uncertainties of clinical options and to assist them in selecting the option that best accommodates their personal preferences. Decision counseling can be offered by 3 types of providers: clinicians who lack formal informed-choice training ("usual care"), clinicians with formal informed-choice training, or trained third parties who function as impartial decision counselors. Controlled studies are needed to determine which model is best, but none appears to be ideal. The health care system cannot truly support informed decision making without correcting the underlying obstacles that impede patient access to needed information. New information technology solutions, training programs, and reimbursement schemes are necessary. Patient demand for guidance will only increase as clinical options multiply and the world of information continues its rapid growth. Today's health care system is unprepared for the convergence of these 2 burgeoning domains, and the need to address systemic deficiencies will grow more urgent over time.