全文获取类型
收费全文 | 4272篇 |
免费 | 249篇 |
国内免费 | 17篇 |
专业分类
耳鼻咽喉 | 36篇 |
儿科学 | 156篇 |
妇产科学 | 32篇 |
基础医学 | 719篇 |
口腔科学 | 99篇 |
临床医学 | 277篇 |
内科学 | 1132篇 |
皮肤病学 | 31篇 |
神经病学 | 308篇 |
特种医学 | 100篇 |
外科学 | 751篇 |
综合类 | 8篇 |
预防医学 | 94篇 |
眼科学 | 78篇 |
药学 | 275篇 |
中国医学 | 18篇 |
肿瘤学 | 424篇 |
出版年
2023年 | 41篇 |
2022年 | 48篇 |
2021年 | 92篇 |
2020年 | 45篇 |
2019年 | 65篇 |
2018年 | 94篇 |
2017年 | 58篇 |
2016年 | 81篇 |
2015年 | 85篇 |
2014年 | 102篇 |
2013年 | 126篇 |
2012年 | 242篇 |
2011年 | 284篇 |
2010年 | 125篇 |
2009年 | 143篇 |
2008年 | 225篇 |
2007年 | 232篇 |
2006年 | 263篇 |
2005年 | 235篇 |
2004年 | 240篇 |
2003年 | 218篇 |
2002年 | 195篇 |
2001年 | 94篇 |
2000年 | 100篇 |
1999年 | 84篇 |
1998年 | 70篇 |
1997年 | 40篇 |
1996年 | 38篇 |
1995年 | 35篇 |
1994年 | 34篇 |
1993年 | 34篇 |
1992年 | 88篇 |
1991年 | 79篇 |
1990年 | 61篇 |
1989年 | 46篇 |
1988年 | 42篇 |
1987年 | 48篇 |
1986年 | 41篇 |
1985年 | 46篇 |
1984年 | 20篇 |
1983年 | 22篇 |
1981年 | 17篇 |
1979年 | 34篇 |
1978年 | 18篇 |
1976年 | 12篇 |
1974年 | 13篇 |
1973年 | 12篇 |
1969年 | 18篇 |
1968年 | 13篇 |
1967年 | 11篇 |
排序方式: 共有4538条查询结果,搜索用时 31 毫秒
991.
Manabu Tsukamoto Toshiharu Mori Hideo Ohnishi Soshi Uchida Akinori Sakai 《The Journal of arthroplasty》2017,32(12):3771-3776
Background
A number of studies on total hip arthroplasty have compared highly cross-linked polyethylene (HXLPE) with conventional polyethylene (CPE) liners beyond 10 years. However, the impact of HXLPE on the wear-related reoperation rate is unclear. The purpose of this study was to evaluate the clinical advantage of using a single manufacturer's HXLPE in terms of reducing the reoperation rate.Methods
The study was a follow-up retrospective cohort study over a mean of 12 years that examined patients aged 45-70 years with cementless total hip arthroplasty using a 26-mm-diameter cobalt-chromium head. Sixty-seven patients (79 hips; HXLPE group = 41 hips, CPE group = 38 hips) were evaluated for a minimum 10-year follow-up. Kaplan-Meier survival analysis was performed, with wear-related reoperations and radiographic osteolysis serving as the end points. The polyethylene wear rate was also assessed.Results
The mean 12-year follow-up rates of survivorship that were evaluated using wear-related reoperations as the end point were 100% and 91.4% in the HXLPE and CPE groups, respectively (P = .007), and the mean 12-year follow-up rates of survivorship with osteolysis as the end point were 100% and 36.2%, respectively (P < .001). Compared with the CPE group, the HXLPE group presented a significantly reduced wear rate (HXLPE group, 0.035 mm/y; CPE group, 0.118 mm/y).Conclusion
A unique strength of this study is that we assessed a single manufacturer's HXLPE while keeping most other implant parameters uniform. This study reveals the clinical advantage of using a single manufacturer's HXLPE in terms of a reduced wear-related reoperation rate at a mean 12-year follow-up. 相似文献992.
Shimpei Yamashita Yasuo Kohjimoto Yasuo Hirabayashi Takashi Iguchi Akinori Iba Masatoshi Higuchi Hiroyuki Koike Takahito Wakamiya Satoshi Nishizawa Isao Hara 《BMC urology》2017,17(1):103
Background
It remains controversial as to whether active stone removal should be performed in patients with poor performance status because of their short life expectancy and perioperative risks. Our objectives were to evaluate treatment outcomes of active stone removal in patients with poor performance status and to compare life prognosis with those managed conservatively.Methods
We retrospectively reviewed 74 patients with Eastern Cooperative Oncology Group performance status 3 or 4 treated for upper urinary tract calculi at our four hospitals between January 2009 and March 2016. Patients were classified into either surgical treatment group or conservative management group based on the presence of active stone removal. Stone-free rate and perioperative complications in surgical treatment group were reviewed. In addition, we compared overall survival and stone-specific survival between the two groups. Cox proportional hazards analysis was performed to investigate predictors of overall survival and stone-specific survival.Results
Fifty-two patients (70.3%) underwent active stone removal (surgical treatment group) by extracorporeal shock wave lithotripsy (n = 6), ureteroscopy (n = 39), percutaneous nephrolithotomy (n = 6) or nephrectomy (n = 1). The overall stone-free rate was 78.8% and perioperative complication was observed in nine patients (17.3%). Conservative treatment was undergone by 22 patients (29.7%) (conservative management group). Two-year overall survival rates in surgical treatment and conservative management groups were 88.0% and 38.4%, respectively (p < 0.01) and two-year stone-specific survival rates in the two groups were 100.0% and 61.3%, respectively (p < 0.01). On multivariate analysis, stone removal was not significant, but was considered a possible favorable predictor for overall survival (p = 0.07). Moreover, stone removal was the only independent predictor of stone-specific survival (p < 0.01).Conclusions
Active stone removal for patients with poor performance status could be performed safely and effectively. Compared to conservative management, surgical stone treatment achieved longer overall survival and stone-specific survival.993.
Patch testing is performed to find out the causative allergens for patients, and once they are found, to indicate the exclusive usage of daily necessities that do not contain the causative allergens is necessary, such as when the contact dermatitis is recurrent, persistent, or complicated by secondary hyperpigmentation. Such a procedure has been called "allergen control." Sufficient success has been obtained in the categories of soaps, shampoos, cosmetics, underwear, and some dental metals in Japan with cooperation of industries, and summaries of these investigations are reported. 相似文献
994.
Soichi Narumoto Seisuke Sakamoto Kengo Sasaki Yoshihiro Hirata Akinari Fukuda Toru Uchiyama Rie Irie Takako Yoshioka Mureo Kasahara 《Pediatric transplantation》2019,23(1)
Desensitization with RTX has been broadly introduced in adult LT across the ABO blood type barrier. For pediatric LT, the prophylactic use of RTX has not been standardized, especially for children under 2 years of age. A 20‐month‐old girl with BA underwent living donor LT from her ABO‐I mother. On POD 6, she developed combined T cell‐mediated and AMRs. Steroid bolus injection was immediately introduced, followed by antibody‐depleting therapy with PE and IVIG. Based on a peripheral blood lymphocyte analysis by fluorescence‐activated cell sorting, ATG and RTX were introduced for refractory rejection. Although she recovered from the combined rejections, IHBCs were inevitable as a consequence. We recommend extending the desensitization protocol to cover children under 2 years of age in order to prevent life‐threatening complications. 相似文献
995.
Three‐dimensional finite element analysis of zirconia all‐ceramic cantilevered fixed partial dentures with different framework designs
下载免费PDF全文
![点击此处可从《European journal of oral sciences》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Shoko Miura Shin Kasahara Shinobu Yamauchi Hiroshi Egusa 《European journal of oral sciences》2017,125(3):208-214
The purpose of this study were: to perform stress analyses using three‐dimensional finite element analysis methods; to analyze the mechanical stress of different framework designs; and to investigate framework designs that will provide for the long‐term stability of both cantilevered fixed partial dentures (FPDs) and abutment teeth. An analysis model was prepared for three units of cantilevered FPDs that assume a missing mandibular first molar. Four types of framework design (Design 1, basic type; Design 2, framework width expanded buccolingually by 2 mm; Design 3, framework height expanded by 0.5 mm to the occlusal surface side from the end abutment to the connector area; and Design 4, a combination of Designs 2 and 3) were created. Two types of framework material (yttrium‐oxide partially stabilized zirconia and a high precious noble metal gold alloy) and two types of abutment material (dentin and brass) were used. In the framework designs, Design 1 exhibited the highest maximum principal stress value for both zirconia and gold alloy. In the abutment tooth, Design 3 exhibited the highest maximum principal stress value for all abutment teeth. In the present study, Design 4 (the design with expanded framework height and framework width) could contribute to preventing the concentration of stress and protecting abutment teeth. 相似文献
996.
997.
T Seki H Okayama S Isoyama Y Kagaya K Shirato K Munakata M Kanazawa K Tamaki T Hiramoto M Okayama S Kasahara 《The Tohoku journal of experimental medicine》1999,187(4):311-322
Alcohol ingestion often provokes attacks in patients with vasospastic angina. Type 2 aldehyde dehydrogenase (ALDH2) deficiency, which is based on a single point mutation (Glu487Lys) of the ALDH2 gene, is common in the Japanese population, but rare among the Caucasian population. We investigated how the genotype of ALDH2 affects the characteristics of alcohol-induced vasospastic angina. Ninety-one patients with vasospastic angina who had ingested alcohol daily or occasionally were studied. Patients had been diagnosed as vasospastic angina by a provocation test with an intracoronary injection of ergonovine or acetylcholine during coronary angiography. The Glu487Lys mutation was detected by allele specific PCR. We interviewed the patients to obtain information concerning the relationship between alcohol ingestion and anginal attacks. Alcohol ingestion induced attacks in 16 of 66 patients without the Glu487Lys mutation, 8 of 22 in heterozygotes, and 1 of 3 in mutant homozygotes. The intervals between alcohol ingestion and the onset of anginal attacks were shorter in homozygotes (0.17 hours) and heterozygotes (1.5+/-0.6 hours) for ALDH2*2 than in normal homozygotes for ALDH2*1 (5.4+/-0.6 hours). The amount of ethanol which induced attacks was significantly greater in normal homozygotes than in homozygotes (11 ml) and heterozygotes (42.5+/-7.1 ml) for ALDH2*2 (96.1+/-13.4 ml in normal patients). The frequency of anginal attacks induced by alcohol ingestion did not differ between ALDH deficient and normal homozygotes. In ALDH deficient patients, however, anginal attacks were induced by a smaller amount of alcohol immediately after its ingestion. Thus, the ALDH2 genotype modifies the characteristics of the anginal attacks as a co-factor for the induction of vasospastic angina after alcohol ingestion. 相似文献
998.
MiCHio Kasahara 《Journal of molecular medicine (Berlin, Germany)》1923,2(41):1889-1890
Ohne Zusammenfassung 相似文献
999.
1000.