全文获取类型
收费全文 | 10384篇 |
免费 | 633篇 |
国内免费 | 50篇 |
专业分类
耳鼻咽喉 | 114篇 |
儿科学 | 238篇 |
妇产科学 | 196篇 |
基础医学 | 1565篇 |
口腔科学 | 178篇 |
临床医学 | 720篇 |
内科学 | 2859篇 |
皮肤病学 | 407篇 |
神经病学 | 702篇 |
特种医学 | 356篇 |
外科学 | 1103篇 |
综合类 | 58篇 |
一般理论 | 1篇 |
预防医学 | 575篇 |
眼科学 | 182篇 |
药学 | 744篇 |
中国医学 | 53篇 |
肿瘤学 | 1016篇 |
出版年
2023年 | 60篇 |
2022年 | 142篇 |
2021年 | 259篇 |
2020年 | 142篇 |
2019年 | 201篇 |
2018年 | 263篇 |
2017年 | 226篇 |
2016年 | 263篇 |
2015年 | 244篇 |
2014年 | 390篇 |
2013年 | 421篇 |
2012年 | 637篇 |
2011年 | 730篇 |
2010年 | 423篇 |
2009年 | 414篇 |
2008年 | 567篇 |
2007年 | 665篇 |
2006年 | 608篇 |
2005年 | 635篇 |
2004年 | 625篇 |
2003年 | 551篇 |
2002年 | 518篇 |
2001年 | 185篇 |
2000年 | 142篇 |
1999年 | 193篇 |
1998年 | 105篇 |
1997年 | 75篇 |
1996年 | 69篇 |
1995年 | 59篇 |
1994年 | 56篇 |
1993年 | 45篇 |
1992年 | 113篇 |
1991年 | 95篇 |
1990年 | 103篇 |
1989年 | 100篇 |
1988年 | 81篇 |
1987年 | 86篇 |
1986年 | 81篇 |
1985年 | 56篇 |
1984年 | 52篇 |
1983年 | 31篇 |
1982年 | 21篇 |
1981年 | 27篇 |
1979年 | 35篇 |
1977年 | 21篇 |
1974年 | 30篇 |
1973年 | 24篇 |
1972年 | 28篇 |
1970年 | 18篇 |
1969年 | 24篇 |
排序方式: 共有10000条查询结果,搜索用时 218 毫秒
11.
12.
Rina Kameyama Akiko Yagami Takashi Yamakita Mamiko Nakagawa Keizou Nagase Hidetaka Ichikawa Kayoko Matsunaga 《Arerugī》2006,55(11):1429-1432
We report here a 76-year-old male that presented with an immediate allergy to Anisakis following saury intake. Three and a half hours after eating pressed saury sushi, whole-body pomphus appeared including itching, facial dropsical swelling, and dyspnea. Diagnostic tests revealed specific IgE antibodies against anisakis simplex and a skin prick test was positive using an extraction of anisakis simplex. The results of skin prick tests using the body and internal organs of a saury were negative. Based on these results, we diagnosed the case as immediate allergy to Anisakis. Anisakis is parasitic to a diverse array of fish, and it seems rare that eating saury will induce an allergic response because the reported parasitic rate of Anisakis on saury is only 5%. In addition, as tropomyosin is currently considered to be the primary cause of allergies to Anisakis, renewed attention should be paid to other foods for which tropomyosin is also assumed to be a common antigen. 相似文献
13.
Keijiro Sunada Hironori Yamamoto Hiroto Kita Tomonori Yano Tomohiko Miyata Yutaka Sekine Akiko Kuno Nobuki Onishi Michiko Iwamoto Atsuhiro Sasaki Kenichi Ido Kentaro Sugano 《Digestive endoscopy》2004,16(3):237-240
The requirement for endoscopic access to a stricture is a major limitation of the endoscopic dilatation for the treatment of strictures in the gastrointestinal tract. We have developed the double‐balloon enteroscopy method that enables visualization of the entire small bowel. In addition, double‐balloon enteroscopy has a potential for the interventional therapy including dilatation of strictures. We present here a case of jejunal strictures in a 47‐year‐old woman with Crohn's disease successfully treated with a balloon catheter in combination with double‐balloon enteroscopy. Balloon dilation with double‐balloon enteroscopy is a promising method for the treatment of small bowel strictures in Crohn's disease. 相似文献
14.
15.
To evaluate the acute effects of anti-asthmatic drugs in vitro, we examined the modulation of various anti-asthmatic drugs in therapeutic concentrations on PAF-induced human eosinophil chemotaxis. Aminophylline (20 micrograms/ml) and Isoproterenol (10 nM) inhibited PAF (3 X 10(-8) M)-induced eosinophil chemotaxis nearly 30%, whereas no inhibitory effects were observed by Dexamethasone (0.1 microM), Tranilast, Ketotifen or Azelastine. Aminophylline (20 micrograms/ml) also inhibited LTB4 (3 X 10(-8) M)-induced eosinophil chemotaxis nearly 30%, whereas it did not inhibit chemotaxis induced by zymosan (5 mg/ml)-activated serum. These results indicate that anti-asthmatic drugs except for aminophylline and isoproterenol, when used acutely in therapeutic concentrations, have no striking inhibitory effects on PAF-induced eosinophil chemotaxis. These results further suggest the possibility that there are different mechanisms in eosinophil chemotaxis induced by PAF, LTB4 or by C5a. 相似文献
16.
Yusuf K. Durlu Sei-ichi Ishiguro Akiko Yoshida Takezo Mito Makio Tsuchiya Makoto Tamai 《Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie》1990,228(1):44-48
We used morphological, biochemical and immunohistochemical methods to assess the response of Müller cells after experimental
lensectomy-vitrectomy in rabbits. We observed widened intercellular spaces between the Müller cells and nerve fibers of ganglion
cells, and increased electron opacity in the Müller cells of eyes injected with silicone oil. No apparent morphological changes
were detected in the Müller cells of air-injected eyes. The specific and total activities of Müller cell-marker enzymes (glucose
6-phosphatase and glutamine synthetase) showed an initial increase, followed by a decrease. Glial fibrillary acidic protein
immunoreactivity was not found in the Müller cells of the normal rabbit retina but was exhibited after surgery. Our results
showed that markers of Müller cells associated with glycogenolysis and/or gluconeogenesis, glutamate-glutamine cycle and cytoskeletal
protein metabolism were affected by the experimental lensectomy-vitrectomy. 相似文献
17.
Proteins from 21 cerebrospinal fluid (CSF) samples (14 derived from neurological cases and 7 from normal individuals) and 15 serum samples (11 from neurological cases and 4 from normal individuals) were analyzed by two-dimensional electrophoresis. Protein mapping revealed a very acidic protein (Ac-P) at about pH 3.5 in the 71% of CSF samples from neurological cases. However, no serum sample contained Ac-P. Ac-P was isolated and purified, and determined to be a glycoprotein containing a large amount of carbohydrate, with molecular weight 42,000 and isoelectric point 2.7-3.3. The amino acid composition of Ac-P was consistent with alpha 1-acid glycoprotein (AGP), and Ac-P was responsive to a commercial anti-AGP antiserum in the radial immunodiffusion test. The known polymorphism of AGP suggests some differences in physicochemical properties such as molecular weight and isoelectric point between AGP in serum and in CSF. Quantitative analysis of Ac-P (AGP) and total protein levels in CSF showed a partial interdependence. Ac-P may be a useful marker for detecting a pathological conditions of the central nervous system. 相似文献
18.
19.
20.
Makoto Ishitobi Yasuo Miyoshi Akiko Ando Seiichi Hasegawa Chiyomi Egawa Yasuhiro Tamaki Morito Monden Shinzaburo Noguchi 《Clinical cancer research》2003,9(4):1376-1380
PURPOSE: The association of BRCA2 polymorphisms at codon 372 [Asn (N)/His (H)]and codon 784 [Met (M)/Val (V)] with breast cancer risk was evaluated in Japanese women. In addition, the prognostic significance of these polymorphisms was studied in breast cancer patients. EXPERIMENTAL DESIGN: A case-control study was conducted to examine the association of the BRCA2 N/H372 polymorphism and M/V 784 polymorphism with breast cancer risk (cases = 149, controls = 154). The prognostic significance of these polymorphisms was evaluated in 139 patients with primary breast cancer. RESULTS: No significant association was observed between the N/H372 polymorphism and breast cancer risk. In contrast, a significant increase in breast cancer risk (odds ratio, 2.03; 95% confidence interval, 1.07-3.87) was observed in carriers of the variant allele (V784) of the M/V784 polymorphism as compared with noncarriers after adjustment for the classical risk factors, age, family history, parity, body mass index, and so forth. Among breast cancer patients, various clinicopathological parameters including menopausal status, tumor size, lymph node status, histological grade, and estrogen-receptor status were not significantly different between the carriers and noncarriers of the variant allele with regard to both N/H372 and M/V784 polymorphisms. The N/H 372 polymorphism was not significantly associated with patient prognosis. On the other hand, breast cancer patients carrying the variant allele of M/V784 polymorphism showed a significantly (P = 0.014) lower 3-year disease-free survival rate (63%) than noncarriers (92%). Multivariate analysis has revealed that the M/V784 polymorphism is a significant prognostic factor, being independent of the other conventional prognostic factors such as lymph node status and estrogen receptor status. CONCLUSION: These results suggest that the M/V784 polymorphism, but not the N/H372 polymorphism, would be useful in the selection of women at high risk for developing breast cancer and would also serve as a clinically useful prognostic factor in breast cancer patients. 相似文献