全文获取类型
收费全文 | 404篇 |
免费 | 15篇 |
国内免费 | 2篇 |
专业分类
耳鼻咽喉 | 3篇 |
儿科学 | 3篇 |
妇产科学 | 8篇 |
基础医学 | 66篇 |
口腔科学 | 20篇 |
临床医学 | 23篇 |
内科学 | 80篇 |
皮肤病学 | 3篇 |
神经病学 | 73篇 |
特种医学 | 5篇 |
外科学 | 58篇 |
综合类 | 2篇 |
预防医学 | 36篇 |
眼科学 | 1篇 |
药学 | 27篇 |
肿瘤学 | 13篇 |
出版年
2023年 | 2篇 |
2022年 | 9篇 |
2021年 | 30篇 |
2020年 | 4篇 |
2019年 | 25篇 |
2018年 | 22篇 |
2017年 | 15篇 |
2016年 | 11篇 |
2015年 | 12篇 |
2014年 | 17篇 |
2013年 | 15篇 |
2012年 | 31篇 |
2011年 | 36篇 |
2010年 | 18篇 |
2009年 | 13篇 |
2008年 | 31篇 |
2007年 | 26篇 |
2006年 | 24篇 |
2005年 | 18篇 |
2004年 | 20篇 |
2003年 | 12篇 |
2002年 | 5篇 |
2001年 | 2篇 |
2000年 | 2篇 |
1999年 | 1篇 |
1998年 | 1篇 |
1997年 | 1篇 |
1996年 | 1篇 |
1995年 | 1篇 |
1994年 | 1篇 |
1989年 | 1篇 |
1988年 | 1篇 |
1987年 | 1篇 |
1985年 | 2篇 |
1982年 | 1篇 |
1979年 | 1篇 |
1977年 | 1篇 |
1973年 | 1篇 |
1972年 | 3篇 |
1971年 | 1篇 |
1969年 | 2篇 |
排序方式: 共有421条查询结果,搜索用时 15 毫秒
351.
F. Javier Pérez-Victoria Guillermo Abascal-Palacios Igor Tascón Andrey Kajava Javier G. Magadán Erik P. Pioro Juan S. Bonifacino Aitor Hierro 《Proceedings of the National Academy of Sciences of the United States of America》2010,107(29):12860-12865
The multisubunit Golgi-associated retrograde protein (GARP) complex is required for tethering and fusion of endosome-derived transport vesicles to the trans-Golgi network. Mutation of leucine-967 to glutamine in the Vps54 subunit of GARP is responsible for spinal muscular atrophy in the wobbler mouse, an animal model of amyotrophic lateral sclerosis. The crystal structure at 1.7 Å resolution of the mouse Vps54 C-terminal fragment harboring leucine-967, in conjunction with comparative sequence analysis, reveals that Vps54 has a continuous α-helical bundle organization similar to that of other multisubunit tethering complexes. The structure shows that leucine-967 is buried within the α-helical bundle through predominantly hydrophobic interactions that are critical for domain stability and folding in vitro. Mutation of this residue to glutamine does not prevent integration of Vps54 into the GARP complex but greatly reduces the half-life and levels of the protein in vivo. Severely reduced levels of mutant Vps54 and, consequently, of the whole GARP complex underlie the phenotype of the wobbler mouse. 相似文献
352.
Aitor de la Quintana Basarrate Francisco Javier Díaz Aguirregoitia Jesús Gil Sánchez Ángel Barturen Barroso Sonia Gaztambide Saez Miguel Echenique Elizondo Luis Perdigo Bilbao 《Cirugía espa?ola》2009,85(6):360-364
Aim
Our aim was to estimate the usefulness of oesophageal endoscopic ultrasound in the accurate location of recurrent or persistent primary hyperparathyroidism (HPT).Material and method
A total of 352 patients with primary hyperparathyroidism were operated on over the last seven years. A preoperative parathyroid 99Tc- sestamibi gammagraphy and an intraoperative PTH determination were performed routinely. Only 5 patients (1.4%) had localization problems: three with persistent HPT after parathyroid extirpation, one recurrent HPT and one HPT after a right hemithyroidectomy. An oesophageal endoscopic ultrasound was carried out before any new exploratory neck surgery in order to find the definitive location.Results
The endoscopic ultrasound showed a clear image of adenoma with an accurate location in four patients. No tumour was present in one patient. All five patients were operated on. The exact location was confirmed in the four patients with positive endoscopic ultrasound images. The fifth surgical exploration revealed a parathyreosis. All five patients had a favourable post-operative period, with no nerve lesions or morbidity associated with the endoscopic ultrasound.Conclusions
Oesophageal endoscopic ultrasound is a very useful diagnostic tool in HPT patients with location problems, particularly in cases having anatomical changes due to previous surgery. It is a procedure that helps the surgeon to make a more selective and efficient exploration of parathyroid glands. 相似文献353.
354.
355.
Crespo-Facorro B Pelayo-Terán JM Pérez-Iglesias R Ramírez-Bonilla M Martínez-García O Pardo-García G Vázquez-Barquero JL 《Journal of psychiatric research》2007,41(8):659-666
Approximately 60% of patients with a first episode of psychosis will significantly reduce the severity of their positive symptomatology with antipsychotic drugs. The aim of this study was to investigate predictors of response to antipsychotic treatment during the first episode of non-affective psychosis. 172 patients (107 male) with a diagnosis of schizophreniform, schizophrenia, schizoaffective, brief reactive psychosis, schizotypal personality disorder or psychosis non-otherwise specified entered the study. Sociodemographic, premorbid and clinical data at baseline were evaluated. Unpaired t-test for continuous and chi2 for categorical data, respectively, were used to compare responders and non-responders selected variables. Multivariate logistic regression was used to establish a prediction model. 57.6% of study subjects (99 of 172) responded to antipsychotic treatment. The following variables were significantly associated with less likelihood of response: 1.--lower severity of general psychopathology, positive symptoms and disorganized symptoms at baseline; 2.--earlier age of onset; 3.--diagnosis of schizophrenia; 4.--longer DUP; 5.--poorer premorbid adjustment during adolescence, and 6.--hospitalization. Multivariate logistic regression demonstrated that differences between responders and non-responders were largely accounted for by BPRS total score, age of onset, premorbid adjustment at early adolescence, and diagnosis. Patients with an early age of onset of schizophrenia, a poor premorbid adolescent functioning, and with a lower severity of psychopathology at intake seem to have a decrease likelihood of responding to antipsychotic treatment. Helping clinicians to identify non-responders is meant as a first step to optimise therapeutic effort to benefit individuals in this vulnerable group. 相似文献
356.
357.
358.
The Effect of Frailty on 30‐day Mortality Risk in Older Patients With Acute Heart Failure Attended in the Emergency Department
下载免费PDF全文
![点击此处可从《Academic emergency medicine》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Francisco Javier Martín‐Sánchez MD PhD Esther Rodríguez‐Adrada MD Christian Mueller MD PhD María Teresa Vidán MD PhD Michael Christ MD PhD W. Frank Peacock MD PhD Miguel Alberto Rizzi MD Aitor Alquezar MD PhD Pascual Piñera MD Paula Lázaro Aragues MD PhD Pere Llorens MD PhD Pablo Herrero MD PhD Javier Jacob MD PhD Cristina Fernández MD PhD Òscar Miró MD PhD 《Academic emergency medicine》2017,24(3):298-307
359.
360.