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排序方式: 共有502条查询结果,搜索用时 15 毫秒
31.
Mounts AW Amr S Jamshidi R Groves C Dwyer D Guarner J Dawson JE Oberste MS Parashar U Spevak P Alexander J 《Pediatric cardiology》2001,22(1):34-39
The true incidence of myocarditis in children is difficult to estimate because many mild cases go undetected. This study
describes an unusual cluster of myocarditis cases that occurred in young children living in the greater Baltimore area between
May and October 1997. A search of multiple comprehensive databases and interviews with area pediatric cardiologists were conducted
to identify unreported cases and determine the background rate of myocarditis in the area. Seven cases of myocarditis were
found as well as two with a similar clinical picture and myocardial fibrosis on tissue examination. Six case patients with
active myocarditis and one child with fibrosis died. The case children were predominantly black (eight of nine) and male (seven
of nine), with no identifiable risk factors. The disease was characterized by a fulminant course with malignant arrhythmias.
The greatest number of pediatric myocarditis deaths reported in 1 year prior to 1997 was three. Myocardial tissues were examined
using immunohistochemistry, in situ hybridization, and polymerase chain reaction but no etiologic agent was identified. This outbreak is unusual because of both
the number of cases and the fulminant course of the disease in this group of children. 相似文献
32.
A 22-year-old woman presented with acute onset of headache and vomiting. Computed tomography (CT) demonstrated hydrocephalus
and a huge midline mass with heterogeneous density involving both lateral ventricles. A small amount of hematoma was detected
at the bottom of the left trigone. On magnetic resonance imaging (MRI), the mass appeared grossly isointense on Tl-weighted
images and slightly hyperintense on T2-weighted images with a clearly demarcated low intensity area at its center. These CT
and MRI findings were suggestive of an acute hemorrhagic event within the tumor. The presence of hemorrhage was confirmed
at surgery. Sudden hemorrhages within the tumor were considered to cause the acute onset of symptoms. Although central neurocytoma
is not commonly known as a tumor-producing intracranial hemorrhage or to cause abrupt clinical deterioration, we found five
similar cases in the literature. After reviewing these cases, we concluded that the information on the possible hemorrhagic
complication of central neurocytoma is important for correct diagnosis and thus for proper management of this tumor.
Received: 11 March 1999 / Accepted: 15 April 1999 相似文献
33.
34.
Jamshid Jamshidi Toshiki Yoshiminel Yukitaka Ushio Toru Hayakawa Kazuyoshi Morimoto Heitaro Mogami 《Journal of neuro-oncology》1987,5(1):65-71
Effects of leptomeningeal tumor on the brain parenchyma was studied by the immunohistochemical method with astroprotein (GFAP) and tubulin in a rat model of meningeal carcinomatosis. Thickening of subpial glial lining (external glial layer) and hypertrophy of subpial astrocytes, detected by the antiserum to GFAP, was the early sign of parenchymal involvement. The glial lining was continuous as far as the tumor cells were confined to the subarachnoid space, however, penetration of tumor cells into subpial brain was associated with disruption of the glial lining. Speculative role of this lining in preventing the tumor cell to infiltrate into brain tissue was discussed. In contrast to the prominent immunohistochemical changes in astrocytes, neuronal tubulin immunoreactivity was not altered even in the late stage of the disease. The present study demonstrated that the leptomeningeal dissemination of tumor cells did cause pathologic change in brain parenchyma as was evidenced by the reactive change of astrocytes. However, the preserved immunoreaction for tubulin suggested that the nerve cell damage was not severe even at the advanced stage of the disease.
address for offprints 相似文献
35.
Edmund R. Hollis II Pouya Jamshidi Karin L?w Armin Blesch Mark H. Tuszynski 《Proceedings of the National Academy of Sciences of the United States of America》2009,106(17):7215-7220
Several experimental manipulations of the CNS environment successfully elicit regeneration of sensory and bulbospinal motor axons but fail to elicit regeneration of corticospinal axons, suggesting that cell-intrinsic mechanisms limit the regeneration of this critical class of motor neurons. We hypothesized that enhancement of intrinsic neuronal growth mechanisms would enable adult corticospinal motor axon regeneration. Lentiviral vectors were used to overexpress the BDNF receptor trkB in layer V corticospinal motor neurons. After subcortical axotomy, trkB transduction induced corticospinal axon regeneration into subcortical lesion sites expressing BDNF. In the absence of trkB overexpression, no regeneration occurred. Selective deletion of canonical, trkB-mediated neurite outgrowth signaling by mutation of the Shc/FRS-2 activation domain prohibited Erk activation and eliminated regeneration. These findings support the hypothesis that the refractory regenerative state of adult corticospinal axons can be attributed at least in part to neuron-intrinsic mechanisms, and that activation of ERK signaling can elicit corticospinal tract regeneration. 相似文献
36.
H Takatera O Maeda T Oka M Namiki E Nakano M Matsuda N Arita J Jamshidi Y Ushio T Sonoda 《The Journal of urology》1986,136(4):799-800
Solitary late recurrence is an unpredictable behavior pattern of renal cell carcinoma. We describe a patient with recurrence at the cranial bone 10 years after surgical management and another with recurrence at the sacral bone 13 years after treatment with radiotherapy and alpha-interferon. Both patients have been followed satisfactorily for 9 months. Unpredictable behavior of renal cell carcinoma makes lifelong followup of patients necessary. If a solitary recurrence is detected operative management definitely should be considered depending on the site of recurrence. 相似文献
37.
M Maruno T Yoshimine Y Ushio T Hayakawa J Jamshidi N Arita S Bitoh H Mogami 《Brain and nerve》1987,39(6):579-585
Distributions of two different subclasses of intermediate filaments, vimentin and glial filaments, were studied immunohistochemically in human brain tumors using specific antiserum to each protein subunit, vimentin and astroprotein (GFAP), Surgical specimens (5 meningiomas, 4 ependymomas, 5 benign astrocytomas, 5 anaplastic astrocytomas and 7 glioblastomas) were fixed in 95% ethanol or ethanol-acidic acid (95:5) and embedded in paraffin Avidin biotin peroxidase-complex (ABC) method (Vectastain) was carried out on 6 microns-thick paraffin sections. All meningioma cells were negative for astroprotein (GFAP) and positive for vimentin. Ependymoma cells showed various patterns of immunoreaction for astroprotein (GFAP) but were invariably positive for vimentin. In benign astrocytomas, many cells (or cell body and processes) were positive for astroprotein (GFAP). Immunoreaction for vimentin was, however, less frequent and intense. In anaplastic astrocytomas, population of astroprotein (GFAP)-positive cells decreased and vimentin-positive cells increased. Astroprotein (GFAP)-positive cells were further decreased in glioblastomas and the population of vimentin-positive cells varied among tissues. The present study suggests that the anaplastic change of astrocytoma cells were associated with decreased expression of glial filaments and increased expression of vimentin filaments. It was also suggests that the expression of both intermediate filaments may be suppressed in highly-malignant glial tumor cells. 相似文献
38.
K Morimoto Y Masana T Hashimoto J Jamshidi T Hayakawa T Ikeda H Mogami 《No shinkei geka. Neurological surgery》1987,15(1):25-30
A prospective high performance liquid chromatography (HPLC) study was performed in eighteen patients with head injury and stroke and four control volunteers to evaluate creatinine and purine metabolites concentration (adenosine, inosine, hypoxanthine, uric acid) in cerebrospinal fluid (CSF). The present HPLC method is rapid, accurate and sensitive in the same isocratic run and no specimen pretreatment of 0.02 ml CSF is necessary. The creatinine level in CSF was increased from 122 to 169 mumol/l in some patients, and was found unrelated to that of serum. The uric acid levels varied between 5.8 and 121 mumol/l and were associated with decrease in Glasgow Coma Scale score and had a critical point of 30 mumol/l. We present initial results in application of HPLC method to measure the creatinine and purine metabolites in CSF. This preliminary report presents that these high levels in CSF of head injury and stroke patients probably reflect tissue damage and an increased tissue catabolism. 相似文献
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40.