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Alberto Fernández Rafael G de Sola Carlos Amo Agustín Turrero Pilar Zuluaga Fernando Maestú Pablo Campo Tomás Ortiz 《Journal of clinical neurophysiology》2004,21(4):254-266
Conventional visual analysis and dipole density analysis of magnetoencephalographic data for both spike and low-frequency magnetic activity were compared for presurgical evaluation in temporal lobe epilepsy (TLE) in a sample of 26 drug-resistant operated TLE patients. A series of logistic regression analyses were performed. Dipole density sensitivity was superior to visual localization analysis. Three separated logistic models were calculated for interictal spikes, low-frequency magnetic activity, and the combination of both measures. A combined interictal spike/low-frequency magnetic activity model predicted correctly the operated temporal lobe in all patients. Clear-cut criteria for the probability model are proposed that are valid for 92.3% of cases in the sample. The quantitative approach proposed by this study is an evidence-based model for presurgical evaluation of temporal lobe epilepsy, which improves previous magnetoencephalographic investigations and establishes working clinical criteria for patient evaluation in TLE. 相似文献
64.
Marco Álvarez-Vega A. Baamonde Mercedes Gutiérrez Agustín Hidalgo L. Menéndez 《Naunyn-Schmiedeberg's archives of pharmacology》1998,358(6):628-634
We have recently shown that spinal calmodulin inhibitors (W-7 and calmidazolium) dose-dependently inhibit the nociceptive
reaction (biting, scratching, licking, BSL) evoked by intrathecal N-methyl-d-aspartate (NMDA) and septide, an agonist of the neurokinin (NK) NK1 receptor. To compare this effect with that induced by standard analgesics, we now report a study of the effects of calmidazolium
(14–420 nmol), bupivacaine (29–582 nmol) and morphine (26–260 nmol) when coadministered intrathecally with either NMDA (4
μg) or septide (0.5 μg). Calmidazolium had the highest potency for inhibiting septide-induced nociceptive behaviour, acting
over a dose range of 34–130 nmol (dose eliciting a half-maximal response, ED50, 67 nmol) lower than that of bupivacaine [ED50 234 (115–475) nmol]. Only the highest dose of morphine (260 nmol) inhibited septide-evoked BSL [ED50=133 (69–255) nmol]. Higher doses of morphine could not be tested due to the appearance of an excitatory aversive reaction.
Both calmidazolium [ED50=232 (138–388) nmol] and bupivacaine [ED50=123 (59–256) nmol] dose-dependently reduced NMDA-induced BSL reaching an almost maximal inhibition at the highest doses assayed
(420 and 291 nmol, respectively). In contrast, morphine had less effect on NMDA-induced behaviour, inducing only a partial
reduction of BSL even with the highest dose assayed (260 nmol). Overall, it can be concluded that the calmodulin inhibitor
calmidazolium inhibits septide- and NMDA-evoked nociceptive behaviour with a potency and efficacy at least as high as those
of morphine and bupivacaine.
Received: 1 April 1998 / Accepted: 4 September 1998 相似文献
65.
Aplicación del método de Gail de cálculo de riesgo de cáncer de mama a la población valenciana 总被引:1,自引:0,他引:1
Ismael Pascual Pastor Climente María M. Morales Suárez-Varela Agustín Llopis González José F. Magraner Gil 《Clinical & translational oncology》2005,7(8):336-343
Background
The objective of this study was to verify whether the method defined by Gail is applicable and predictive in a population of women in Valencia (Spain).Population and methods
Of the 685 patients diagnosed with breast cancer and attended-to in 2000–2001, 186 incident cases were identified. The variables studied were obtained from a specific questionnaire which included characteristics of reproductive history, number of biopsies and contraceptive pill consumption prior to the diagnosis. Using the model of the National Surgical Adjuvant Breast and Bowel Project (NSABP), an adaptation of the Gail model, the risk of developing breast cancer at 5 years was estimated.Results
Only 40% of those women diagnosed as having breast cancer would have been identified as a high-risk patient by the Gail method. With our population group, the method detected the elderly women with a medical history of breast cancer who developed advanced stage disease.Conclusions
The Gail method does not adapt well to the study population of Valencia. It would be necessary to add other risk-factors to the Gail method so as to identify more patients in our area. 相似文献66.
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Nutcracker or left renal vein compression phenomenon: multidetector computed tomography findings and clinical significance 总被引:3,自引:0,他引:3
Cuéllar i Calàbria H Quiroga Gómez S Sebastià Cerqueda C Boyé de la Presa R Miranda A Alvarez-Castells A 《European radiology》2005,15(8):1745-1751
The use of multidetector computed tomography (MDCT) in routine abdominal explorations has increased the detection of the nutcracker phenomenon, defined as left renal vein (LRV) compression by adjacent anatomic structures. The embryology and anatomy of the nutcracker phenomenon are relevant as a background for the nutcracker syndrome, a rare cause of hematuria as well as other symptoms. MDCT examples of collateral renal vein circulation (gonadal, ureteric, azygous, lumbar, capsular) and aortomesenteric (anterior) and retroaortic (posterior) nutcracker phenomena in patients with no urologic complaint are shown as well as studies performed on patients with gross hematuria of uncertain origin. Incidental observation of collateral veins draining the LRV in abdominal MDCT explorations of asymptomatic patients may be a sign of a compensating nutcracker phenomenon. Imbalance between LRV compression and development of collateral circulation may lead to symptomatic nutcracker syndrome. 相似文献
70.
Cuadrado A Orive A García-Suárez C Domínguez A Fernández-Escalante JC Crespo J Pons-Romero F 《Obesity surgery》2005,15(3):442-446
Non-alcoholic fatty liver disease (NAFLD) is characterized by an excessive accumulation of fatty acids and triglycerides within
the cytoplasm of the hepatocytes of non-alcohol users. The natural history varies according to the initial histological diagnosis.
A current consideration is that cryptogenic cirrhosis may be representative of a late stage of non-alcoholic steatohepatitis
(NASH), which has lost its features of necroinflammatory activity and steatosis in up to 80% of patients. Since NASH is able
to progress to cirrhosis, hepatocellular carcinoma (HCC) development may be an end-stage of this disease. We report below
two clinical cases of patients diagnosed with NASH who developed HCC. The relationship between NAFLD and HCC is reviewed. 相似文献