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41.
Nkouawa A Okamoto M Mabou AK Edinga E Yamasaki H Sako Y Nakao M Nakaya K Blair D Agatsuma T Enyong P Shibahara T Moyou-Somo R Ito A 《Transactions of the Royal Society of Tropical Medicine and Hygiene》2009,103(3):255-261
Paragonimiasis is a common parasitic zoonosis in Cameroon and neighbouring countries in Western Africa. Serum, sputum and faecal samples were collected in an endemic area of South West Province, Cameroon, after administration of a questionnaire to identify individuals with appropriate symptoms and histories. Microscopic examination revealed eggs in sputum from 16 people, but none in any faecal sample. These 16 were among the 25 and 26 people, respectively, positive by ELISA and by immunoblot using Paragonimus africanus crude antigens. Copro-DNA detection was attempted using 23 faecal samples (18 from sputum egg-negative and five from sputum egg-positive individuals). Copro-DNA was detected in four of the five sputum egg-positive individuals. These results strongly suggest that: (1) serology is much more sensitive than sputum examination for diagnosis of paragonimiasis; and (2) a copro-DNA test may be more sensitive than a microscopic search for eggs in faeces. Molecular sequence data from ITS2 and cox1 genes confirmed that adult worms experimentally raised in cats were P. africanus and that eggs from sputum or other worm products from human faeces also belonged to this species. Based on these results, 26 of 168 persons (15.5%) were diagnosed as suffering from paragonimiasis. 相似文献
42.
Tom J. Levett Jaime H. Vera Christopher I. Jones Stephen Bremner Agathe Leon Josip Begovac Ludwig Apers Margarida Borges Sime Zekan Eugenio Teofilo Felipe Garcia Jennifer Whetham the EmERGE Consortium 《HIV medicine》2023,24(4):431-441
Objective
To evaluate frailty, falls and perceptions of ageing among clinically stable individuals with HIV, engaged with remote healthcare delivered via a novel smartphone application.Methods
This was a multi-centre European cross-sectional, questionnaire-based sub-study of EmERGE participants. Frailty was assessed using the five-item FRAIL scale. Present criteria were summed and categorized as follows: 0, robust; 1–2, pre-frail; 3–5, frail. Falls history and EQ-5D-5L quality of life measure were completed. Participants were asked their felt age and personal satisfaction with ageing.Results
A total of 1373 participated, with a mean age of 45 (± 9.8) years. Frailty was uncommon at 2%; 12.4% fell in the previous year, 58.8% of these recurrently. Mood symptoms and pain were prevalent, at 43.3% and 31.8%, respectively. Ageing satisfaction was high at 76.4%, with 74.6% feeling younger than their chronological age; the mean felt age was 39.3 years. In multivariable analysis, mood symptoms and pain were positively associated with frailty, falls and ageing dissatisfaction. An increase in pain severity and mood symptoms were respectively associated with 34% and 63% increased odds of pre-frailty/frailty. An increment in pain symptoms was associated with a 71% increase in odds of falling. Pain was associated with ageing poorly, as were mood symptoms, with odds of dissatisfaction increasing by 34% per increment in severity.Conclusions
Although uncommon, frailty, falls and ageing dissatisfaction were seen in a younger cohort with medically stable HIV infection using a remote care model, promoting screening as advocated by European guidelines. These were more common in those with pain or mood symptoms, which should be proactively managed in clinical care and explored further in future research. 相似文献43.
Roubertie A Biolsi B Rivier F Humbertclaude V Cheminal R Echenne B 《Brain & development》2003,25(6):442-445
Mutation of the gene for alpha-tocopherol transfer protein causes ataxia with isolated vitamin E deficiency, a disorder usually stabilized or improved after vitamin E supplementation. Dystonia has rarely been described in ataxia with isolated vitamin E deficiency (AVED) patients. We present the case of a young boy with AVED, whose neurological and extra-neurological cardinal symptoms of the disease improved after vitamin E supplementation but who progressively developed generalized dystonia. 相似文献
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45.
Agathe Vialle Pascal Frey Sarah Hambleton Louis Bernier Richard C. Hamelin 《Fungal Diversity》2011,50(1):227-248
We present a review of previous taxonomic treatments of the Melampsora species occurring on poplar and describe the features associated with each spore stage in a typical poplar rust life cycle. The morphological, biological and ecological characters traditionally used for taxonomy are summarized for all Melampsora taxa, including 17 accepted species, 2 formae speciales and 2 hybrids, currently listed in the literature as pathogenic on Populus spp. We discuss the historical taxonomic decisions that led to nomenclatural and classification complications for this group of rusts, and highlight the lack of type material for three species known only from the original collections: M. cumminsii, M. multa, and M. osmaniensis. Even when all the traditional features are considered, the taxonomy of Melampsora poplar rust species remains uncertain and incomplete. An overview of recent molecular studies suggests the need for a comprehensive revision of species concepts, based on phylogenetic relationships. To that end, we propose a polyphasic approach, including the Genealogical Concordance Phylogenetic Species Recognition method, be used to build robust and meaningful systematic framework for the Melampsora poplar rusts. 相似文献
46.
Summary: Ictal and interictal activities occurring in a mature brain can disorganize the neural network activity involved in one or various specific cognitive processes. In children, the situation might be more complex: the epileptic process occurs in a period when the cortex is still maturing and it may interfere with normal cerebral development. Although neural plasticity in children is greater than it is in adults, greater plasticity does not necessarily mean adaptive plasticity. Studies have shown that temporal lobe epilepsy in children is not systematically associated with global mental retardation. However, various difficulties in specific cognitive domains are more often found in children than in patients with adult-onset epilepsy. Language, memory, socioperceptive competence, and also executive functions, which can be impaired by the disruption of the temporofrontal circuit, are among such cognitive functions that need to be evaluated. Early detection of specific deficits is of primary importance for the implementation of appropriate remediation measures. 相似文献
47.
Haelterman E Marcoux S Croteau A Dramaix M 《Scandinavian journal of work, environment & health》2007,33(4):304-317
OBJECTIVES: Preeclampsia is a leading cause of maternal and perinatal morbidity. Work-related factors may influence the occurrence of this disorder. This case-control study estimated the associations between work-related physical and psychosocial factors and the risk of preeclampsia and gestational hypertension. METHODS: The eligible women consisted of a random sample of the women who delivered a singleton live birth in 1997-1999 in six regions of Quebec and worked during pregnancy. Cases of preeclampsia (N=102) and gestational hypertension (N=99) were compared with normotensive controls (N=4381). Information on occupational exposures at the onset of pregnancy was collected during phone interviews a few weeks after delivery. Detailed information was obtained on work schedule, postures, physical exertion, work organization, noise, vibration, and extreme temperature. Adjusted odds ratios (aOR) were estimated through polytomous logistic regression. RESULTS: Women standing daily at least 1 hour consecutively without walking experienced a higher risk of preeclampsia [aOR 2.5, 95% confidence interval (95% CI) 1.4-4.6], as well as women climbing stairs frequently (aOR 2.3, 95% CI 1.2-4.1) and women working more than 5 consecutive days without a day-off (aOR 3.0, 95% CI 1.0-9.5). Squatting or kneeling, pushing or pulling objects, whole-body vibration, forced pace, job strain, and no control on breaks were positively, but nonsignificantly, associated with preeclampsia. The associations were weaker for gestational hypertension. CONCLUSIONS: These findings suggest that being exposed to physically demanding and stressful occupational conditions at the onset of pregnancy increases the risk of preeclampsia. 相似文献
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49.
Intelligence quotient improves after antiepileptic drug withdrawal following pediatric epilepsy surgery
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Kim Boshuisen MD Monique M. J. van Schooneveld MSc Cuno S. P. M. Uiterwaal MD PhD J. Helen Cross MD PhD Sue Harrison MSc Tilman Polster MD Marion Daehn MSc Sarina Djimjadi MSc Dilek Yalnizoglu MD Guzide Turanli MD Robert Sassen MD Christian Hoppe MSc PhD Stefan Kuczaty MD Carmen Barba MD PhD Philippe Kahane MD PhD Susanne Schubert‐Bast MD Gitta Reuner MSc PhD Thomas Bast MD PhD Karl Strobl MD Hans Mayer PhD Anne de Saint‐Martin MD Caroline Seegmuller MD Agathe Laurent MSc Alexis Arzimanoglou MD PhD Kees P. J. Braun MD PhD for the TimeToStop cognitive outcome study group 《Annals of neurology》2015,78(1):104-114
50.
Hamidou MA Batard E Trewick D Masseau A Moreau A Agard C Ponge T Grolleau JY Barrier J 《European Journal of Internal Medicine》2005,16(3):183-186
BACKGROUND: The objective of the present study was to compare the silent form of giant cell arteritis (GCA) to the classic cephalic form of the disease. METHODS: We conducted a retrospective study based on a chart review of 50 consecutive, biopsy-proven GCA, recorded at a department of internal medicine. We sought to distinguish a silent form, defined by a prolonged inflammatory syndrome or fever of unknown origin with the absence of cephalic signs, polymyalgia rheumatica, or large artery involvement, from an overt "classic" cranial temporal arteritis. RESULTS: The prevalence of the silent form of GCA was 46% in our study. Abnormal temporal arteries were more frequent in the cephalic group. The silent GCA group had higher C-reactive protein levels (p<0.05), a higher platelet count (p<0.05), and lower serum albumin (p<0.05). There was no significant difference in temporal artery specimens in the two groups. Clinical relapses tended to be more frequent, and patients free of corticosteroids tended to be less frequent, in the cephalic group, though the difference was not statistically significant. CONCLUSIONS: The silent and cephalic forms of GCA could have distinct clinical and biological patterns and different outcomes. The limitation of our study was its retrospective design. Further studies are required to determine if this distinction is useful in treating GCA patients. 相似文献