1型糖尿病患儿的课堂注意力：稳定血糖的效果

目的:观察评估通过使用胰岛素泵以稳定血糖,是否可以改善1型糖尿病患儿的课堂注意力。试验设计:对4例患有1型糖尿病且血糖水平不稳定的患儿在课堂中的表现进行为期10d的观察。在放置胰岛素泵,控制血糖后再观察10d。利用改良多基线设计血糖控制水平是否与患儿专注于功课和走神行     

坤怡宁对雌性去卵巢大鼠生殖内分泌-免疫的影响

目的：探讨坤怡宁颗粒治疗妇女更年期综合征的内在机制。方法：以去卵巢大鼠为模型,观察坤怡宁颗粒对去卵巢大鼠体重和子宫、胸腺、肾上腺等脏器系数的影响；用放免试剂盒检测血清雌二醇（E₂）,促卵泡激素（FSH）,黄体生成素（LH）,泌乳素（PRL）,白细胞介素-2（IL-2）,骨钙素（BGP）的含量。结果：坤怡宁能增加去卵巢大鼠子宫和肾上腺系数,提高其降低的E₂,IL-2和BGP,显著降低去卵巢大鼠升高的FSH,LH和PRL。结论：坤怡宁对去卵巢大鼠神经内分泌-免疫紊乱有较好的调节作用。     

Short-wavelength automated perimetry in patients with migraine

Background The aim was to investigate short-wavelength sensitivity deficits in patients with migraine.Methods Fifteen migraine and 18 age-matched healthy volunteers with normal ophthalmologic examination participated in this study. Migraine characteristics were graded by the Migraine Disability Assessment Questionnaire (MIDAS). All participants underwent SWAP (short wavelength amplitude perimetry) testing using a Humphrey field analyzer; there was a 30-2 presentation pattern.Results Short wavelength amplitude perimetry parameters for mean deviation (MD; p<0.0001) and pattern standard deviation (PSD; p<0.0001) were significantly worse in the migraine group. In the migraine group 53.3%. of eyes had glaucoma hemi-field tests (GHT) outside normal limits and 10 of these had early glaucomatous visual field loss. Statistically significant correlations were found between frequency of migraine attacks and MD (p=0.02; r=0.56) and PSD (p=0.03; r=0.41) and also between the MIDAS score and MD (p=0.03; r=0.49) and PSD (p=0.04; r=0.51). In all migraine cases with early glaucomatous visual field defect a corresponding site of the head was predominantly involved in headache (p=0.03).Conclusion Some patients with severe migraine have earlier defects on SWAP suggesting a common vascular insult of glaucoma and migraine, and all migraine cases with high MIDAS scores should be further evaluated for early glaucomatous visual field defects using SWAP.     

Alpha interferon and lamivudine combination therapy for chronic hepatitis B in children

BACKGROUND: Lamivudine is a new alternative therapeutic agent for chronic hepatitis B, in which alpha interferon (IFN-alpha) monotherapy is not successful enough. Published reports have revealed no satisfactory data on IFN-alpha and lamivudine combination therapy in children. The aim of this study is to investigate the efficacy and safety of this combination therapy in children with chronic hepatitis B. METHODS: Children with chronic hepatitis B were given either IFN-alpha and lamuvidine (group 1, n = 47) or IFN-alpha alone (group 2, n = 30). Alpha interferon was administered as 5 million U/m2 s.c., thrice a week for 6 months and lamivudine 4 mg/kg per day p.o., maximum 100 mg, for 1 year. Clinical examination was performed; blood cell counts and serum alanine aminotransferase (ALT) and amylase were studied at each visit. At the third, sixth and twelfth month, serological markers were determined. RESULTS: End of therapy response was achieved in 19 (40.4%) patients in group 1 and in 14 (46.7%) children in group 2 (P > 0.05). In group 1, pretreatment serum ALT and hepatic activity index (HAI) were statistically higher in children who responded to therapy (P < 0.005). In group 2, mean serum ALT was higher and hepatitis B virus (HBV) DNA was lower in responders. Sustained response rate was 40.4 versus 43.3% in two groups. CONCLUSION: The response rate of IFN-alpha and lamivudine combination therapy in children with chronic hepatitis B was similar to that of IFN-alpha monotherapy. High ALT level and HAI, rather than low HBV-DNA level were found to be important predictors of response.     

中医疗效系统评价体系的研究

临床疗效是中医药学生存和发展的基础,建立中医临床疗效系统评价体系,对于科学、客观、系统地开展中医临床疗效的评价具有重要意义。本文研究并探讨了建立中医临床疗效系统评价体系所需达到的目标和发展思路,提出了建立该系统的重点任务及关键技术。     

情志疾病的中医药防治研究与养生保健理论与方法的研究——中医现代化临床研究(二)

本文针对现代生活对人们健康危害严重的情志疾病，指出应该发掘中医对情志致病的发病机理，探索情志的伤脏规律，从而建立科学的中医学防治情志疾病的疗效评价方法。和有效的防治药物及方案；同时以老年人和更年期妇女两大人群为重点研究对象，研究了养生保健方法在解决老龄化相关疾病，亚健康状态所要达到的目标和发展思路，本文对此列出了与之对应的相关重点任务和关键技术。     

Gastroduodenal artery aneurysm broken in duodenum. A rare cause of upper digestive tract hemorrhage

The authors present a case of recidivated upper digestive tract hemorrhage, in which the bleeding initially stopped under conservative treatment. Imagery showed a piloro-duodenal stenosis. During the preoperative care the hemorrhage is resumed abruptly imposing emergency operation. The lesion was an intraoperative surprise imposing the hemostasis at first, and then the surgical management of lesions of the digestive tract.     

Abscesses of psoas in diabetic patients: anatomo-clinical and therapeutical peculiarities

Difficulties of diagnosis and of an adequate treatment of psoas muscle abscesses are increased by the evolution of the suppurative process in diabetic patients. We review 3 cases of poses muscle abscesses, characterized by a long-term evolution until revealing the initial source of the abscess and by particular clinical features, due to the exteriorization of suppuration far away from its source (retrosacral, hip, thigh). Computerized tomography is essential for diagnosis and for an accurate therapeutical approach, consisting in incision and drainage of primary abscess in psoas muscle and of its expansions as well in the same time, with an adequate antibiotherapy.