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71.
Tamburlini G Cattaneo A 《The New England journal of medicine》2007,357(18):1866-7; author reply 1867-8
72.
Marianna Teixeira de Pinho Favaro Naroa Serna Laura Sánchez-García Rafael Cubarsi Mónica Roldán Alejandro Sánchez-Chardi Ugutz Unzueta Ramón Mangues Neus Ferrer-Miralles Adriano Rodrigues Azzoni Esther Vázquez Antonio Villaverde 《Nanomedicine : nanotechnology, biology, and medicine》2018,14(6):1777-1786
Arginine-rich protein motifs have been described as potent cell-penetrating peptides (CPPs) but also as rather specific ligands of the cell surface chemokine receptor CXCR4, involved in the infection by the human immunodeficiency virus (HIV). Polyarginines are commonly used to functionalize nanoscale vehicles for gene therapy and drug delivery, aimed to enhance cell penetrability of the therapeutic cargo. However, under which conditions these peptides do act as either unspecific or specific ligands is unknown. We have here explored the cell penetrability of differently charged polyarginines in two alternative presentations, namely as unassembled fusion proteins or assembled in multimeric protein nanoparticles. By this, we have observed that arginine-rich peptides switch between receptor-mediated and receptor-independent mechanisms of cell penetration. The relative weight of these activities is determined by the electrostatic charge of the construct and the oligomerization status of the nanoscale material, both regulatable by conventional protein engineering approaches. 相似文献
73.
Peri-implant bone regeneration with calcium sulfate: a light and transmission electron microscopy case report 总被引:1,自引:0,他引:1
BACKGROUND: Calcium sulfate is a simple, biocompatible material with a very long, safe clinical history in several different fields of medicine. It is a rapidly resorbing material that leaves behind calcium phosphate lattice, which promotes bone regeneration. OBJECTIVE: The aim of this study was a histological and ultrastructural evaluation of the tissues in a peri-implant site regenerated with calcium sulfate. MATERIALS AND METHODS: The specimens were processed for observation under light and transmission electron microscopes. RESULTS: In light microscopy, trabecular bone was present. No remnants of calcium sulfate were present. Transmission electron microscopy showed, in the areas of the interface with the implant surface, features of mature bone with many osteocytes. An amorphous layer and/or osteoid seam separated this mature bone from the metal surface. CONCLUSION: The results confirm the high biocompatibility and rapid resorption of calcium sulfate. 相似文献
74.
Shibli JA Grassi S de Figueiredo LC Feres M Iezzi G Piattelli A 《Implant dentistry》2007,16(3):252-259
PURPOSE: The aim of this study was to evaluate the influence of oxidized surface on bone-to-implant contact percentage (BIC%) as well as the bone density within the threads area (BD%) in human bone after 2 months of unloaded healing. MATERIALS: Seven subjects (mean age 45.57 +/- 10.45 years) received 2 micro-implants each during conventional implant surgery in the posterior maxilla. The implants that presented turned and oxidized surfaces served as control and test, respectively. After the healing period, the implants and the surrounding tissue were removed and prepared for ground sectioning and analysis. RESULTS: Two turned implants were found to be clinically unstable at the time of retrieval. Histometric evaluation showed that the mean of BIC% was 17.40 +/- 14.16% and 32.19 +/- 15.68% to turned and oxidized surfaces, respectively. The BD% was 22.13 +/- 19.06% for turned surface and 50.40 +/- 18.35% for oxidized surface. CONCLUSION: The histologic data from this preliminary study suggest that the oxidized micro-implants surface presented better mean values of BIC% and BD% than turned micro-implants after a short healing time. 相似文献
75.
PURPOSE: This study was an immunohistochemical evaluation of microvessel density (MVD) in sinus augmentation procedures with autologous bone and anorganic bone (Bio-Oss). MATERIALS AND METHODS: Twenty-four patients (14 men and 10 women - mean age of 48 years with a range from 34 to 53 years) participated in this study. All the patients presented a maxillary partial unilateral edentulism involving the premolar/molar areas, with a residual alveolar ridge height of about 4 to 5 mm. Twelve patients received sinus augmentation procedures with 100% autologous bone; 100% Bio-Oss was used in the other 12 patients. Endosseous implants were inserted after a mean period of 3 months. As control, the portions of preexisting subantral bone were used. The mean value of the MVD in control bone was 23.4 +/- 1.3. The mean value of the MVD in the sinuses augmented with autologous bone was 29.0 +/- 2.4. The mean value of the MVD in the sinuses augmented with Bio-Oss was 23.8 +/- 2.2. RESULTS: The statistical analysis showed that the differences of the MVD between control bone and sinuses augmented with Bio-Oss were not statistically significant (P = 0.52), while the difference of the MVD between sinuses augmented with autologous bone and those augmented with Bio-Oss was statistically significant (P = 0.0008). CONCLUSIONS: Autologous bone may act not only as a passive filling material in bone defects but may also release osteogenic growth factors; and particles of autologous bone seem to contain vital osteoprogenitor cells. 相似文献
76.
Spini TH Sargenti-Neto S Cardoso SV Souza KC de Souza SO de Faria PR Loyola AM 《Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics》2007,104(3):e40-e45
Regional odontodysplasia (RO), also known as ghost teeth, is an unusual nonhereditary developmental anomaly of tooth formation that characteristically affects enamel and dentin formation of the primary and/or permanent dentition. In the present paper, we report a case of RO affecting a 7-year-old boy, with 9 years of follow-up. During this time, progressive development of dental tissue was observed, including complete root formation. However, delayed dental eruption was evident. In view of these findings, we discuss the clinical presentation, pathogenesis, differential diagnosis, and treatment of RO. 相似文献
77.
Maspin expression in oral squamous cell carcinoma 总被引:1,自引:0,他引:1
Iezzi G Piattelli A Rubini C Goteri G Artese L Perrotti V Carinci F 《The Journal of craniofacial surgery》2007,18(5):1039-1043
Maspin (mammary serine protease inhibitor) is a member of the serpin superfamily of protease inhibitors and it has a role as a tumor suppressor. Maspin has been reported to be important in processes relevant to tumor growth and metastasis such as cell invasion, angiogenesis, and apoptosis. A high expression of maspin was correlated with better rates of survival and absence of nodal metastases in head and neck squamous cell carcinoma. In contrast, some studies have shown that maspin overexpression is correlated with a poor prognosis in pancreatic and ovarian cancers and in lung adenocarcinoma. The aim of this study was an immunohistochemical evaluation of the maspin expression in oral squamous cell carcinoma and thus 89 patients were evaluated. Maspin expression in oral squamous cell carcinoma was significantly associated with the tumor differentiation grade (chi test: P = 0.0318) and the lymph node status (chi test: P < 0.005), but not with the tumor stage (chi test: P = 0.666). Metastatic involvement of lymph nodes was observed more frequently in maspin-negative cases than in tumors with more than 5% of positive cells (P = 0.0024). The present results confirm that maspin expression predicts a better prognosis in oral squamous cell carcinoma and that maspin probably plays a role in tumor progression. 相似文献
78.
In the last two decades, several investigators have reported immediate placement of dental implants into extraction sockets achieving excellent results with a two-stage surgical procedure. Recently, immediate loading (IL) has become an emerging technique because it has been documented to be a successful and time-saving procedure. Regarding the possibility of immediate/early loading of implants placed in fresh extraction sockets, few reports are available. In addition, they are based on limited series with short follow up. Thus, we decided to perform a retrospective study on a large series of postextractive IL implants. From January 1995 to October 2004, 416 IL fixtures were placed immediately after extraction and 658 IL fixtures in healed sites. The mean follow up is 3 years. Multiple implant systems were used. Because only eight of 1,074 implants were lost (i.e., survival rate, 99.3%) and no statistical differences were detected among the studied variables, no or reduced marginal bone loss was considered as an indicator of success rate to evaluate the effect of several host-, surgery-, and implant-related factors. A general linear model was then performed to detect those variables statistically associated with marginal bone loss. Only eight of 1,074 implants were lost (i.e., survival rate, 99.3%) and no differences were detected among the studied variables. On the contrary, the general linear model showed that younger age (cutoff, 55 years) and harder bone are related to a lower delta insertion abutment junction (or marginal bone loss) and thus a better outcome. We demonstrated that postextractive IL implants have a high survival rate and success rate that are similar to those reported in previous studies of two-stage procedures or in IL implants inserted in healed bone. Poor bone quality and older age correlate with a slight higher bone resorption. 相似文献
79.
80.
Aline Moraes MENACHO Adriano REIMANN Lie Mara HIRATA Caroline GANZERELLA Flavio Heuta IVANO Ricardo SUGISAWA 《Brazilian archives of digestive surgery》2014,27(1):9-12