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991.
Qaisar Abbas M. Emre Celebi Irene Fondón García Muhammad Rashid 《Skin research and technology》2011,17(1):91-100
Background/purpose: Automated border detection is an important and challenging task in the computerized analysis of dermoscopy images. However, dermoscopic images often contain artifacts such as illumination, dermoscopic gel, and outline (hair, skin lines, ruler markings, and blood vessels). As a result, there is a need for robust methods to remove artifacts and detect lesion borders in dermoscopy images. Methods: This automated method consists of three main steps: (1) preprocessing, (2) edge candidate point detection, and (3) tumor outline delineation. First, algorithms to reduce artifacts were used. Second, a least‐squares method (LSM) was performed to acquire edge points. Third, dynamic programming (DP) technique was used to find the optimal boundary of the lesion. Statistical measures based on dermatologist‐drawn borders were utilized as ground‐truth to evaluate the performance of the proposed method. Results: The method is tested on a total of 240 dermoscopic images: 30 benign melanocytic, 50 malignant melanomas, 50 basal cell carcinomas, 20 Merkel cell carcinomas, 60 seborrheic keratosis, and 30 atypical naevi. We obtained mean border detection error of 8.6%, 5.04%, 9.0%, 7.02%, 2.01%, and 3.24%, respectively. Conclusions: The results demonstrate that border detection combined with artifact removal increases sensitivity and specificity for segmentation of lesions in dermoscopy images. 相似文献
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Sabba Mehmood M.Phil. Sayed Hajan Shah M.Phil. Abid Jan M.Phil. Muhammad Younus M.Phil. Farooq Ahmad M.Phil. Muhammad Ayub M.Phil. Wasim Ahmad Ph.D. 《Pediatric dermatology》2016,33(1):e40-e42
Hypotrichosis is a condition of abnormal hair pattern characterized by sparse to absent hair on different parts of the body, including the scalp. The condition is often characterized by tightly curled woolly hairs, discoloration of hair, and development of multiple keratin filled cysts or papules on the body. Sequence analysis of the lipase H (LIPH) gene, mapped on chromosome 3q27.3, led to the identification of a novel frameshift deletion variant (c.932delC, p.Pro311Leufs*3) in one family and previously reported 2‐bp deletion (c.659_660delTA) in five other families, inherited hypotrichosis, and woolly hair in an autosomal recessive pattern. The study further extends the body of evidence that sequence variants in the LIPH gene result in hypotrichosis and woolly hair phenotype. 相似文献
996.
Muhammad Amjad Khan M.Sc. F.R.C.P.C.H. Lindsay Shaw F.R.C.P. F.R.C.P.C.H. Despina Eleftheriou Ph.D. M.R.C.P.C.H. Prab Prabhakar F.R.C.P.C.H. Wui K. Chong M.D. F.R.C.R. Mary Glover M.A. F.R.C.P. F.R.C.P.C.H. 《Pediatric dermatology》2016,33(2):e95-e98
We report the case of a young girl who presented with hemiparesis, seizures, and subtle features consistent with a linear form of facial morphea (en coup de sabre). She was treated with pulsed parenteral steroids and oral steroids and started on methotrexate. Magnetic resonance imaging results and neurologic problems improved after 6 months. Switching off inflammation early in the course of disease seemed to reverse some of the central nervous system changes. Assessment of children with unexplained hemiparesis and seizures should include careful examination of the face and scalp, looking for subtle signs of skin change and asymmetry. This is one of the few reported cases of neuroradiologic improvement after immunosuppressive treatment in a child with en coup de sabre. 相似文献
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Cowden syndrome (CS) is an autosomal dominant genodermatosis associated with characteristic mucocutaneous findings of facial trichilemmomas, palmoplantar keratoses, sclerotic fibromas, and oral papillomas. Mucocutaneous neuromas have also been reported in association with CS. We describe a patient with CS whose sole cutaneous finding was palisaded encapsulated neuromas (PENs) with a plexiform growth pattern in an acral location. Along with previous reports, this case suggests that acral plexiform PENs may be an early, highly specific finding in CS and highlights the importance of screening these patients for PTEN mutation. 相似文献
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