Sai Priyanka Mellacheruvu  Sai Prasanna Lekkala  Sukhjinder Chauhan  Adil Sarvar Mohammed  Sravya R Mundla  Ankita Shenoy  Bilal Khan Mohammed  Jerrin Bawa  Shantha Nallapothula  Priyatham Gurram  Akhil Jain  Rupak Desai  Mohammed Mustafa Nayeem 《World journal of gastrointestinal pathophysiology》2024,15(3)

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Adil Bayramoğlu  Hakan Taşolar  Ahmet Kaya  İbrahim Halil Tanboğa  Mehmet Yaman  Osman Bektaş  Zeki Yüksel Günaydın  Vecih Oduncu 《Journal of interventional cardiology》2018,31(2):144-149

Background

No‐reflow is associated with a poor prognosis in STEMI patients. There are many factors and mechanisms that contribute to the development of no‐reflow, including age, reperfusion time, a high thrombus burden, Killip class, long stent use, ejection fraction ≤40, and a high Syntax score. In this study, we aimed to evaluate the parameters associated with no‐reflow prediction by creating a new scoring system.

Methods

The study included 515 consecutive STEMI patients who underwent PCI; 632 STEMI patients who had undergone PCI in another center were included in the external validation of the scoring system. The correlations between 1‐year major adverse cardiac events and low/high risk score were assessed.

Results

In this study, seven independent variables were used to build a risk score for predicting no‐reflow. The predictors of no‐reflow are age, EF ≤40, SS ≥22, stent length ≥20, thrombus grade ≥4, Killip class ≥3, and pain‐balloon time ≥4 h. In the derivation group, the optimal threshold score for predicting no‐reflow was >10, with a 75% sensitivity and 77.7% specificity (Area under the curve (AUC) = 0.809, 95%CI: 0.772‐0.842, P < 0.001). In the validation group, AUC was 0.793 (95%CI: 0.760‐0.824, P < 0.001).

Conclusion

This new score, which can be calculated in STEMI patients before PCI and used to predict no‐reflow in STEMI patients, may help physicians to estimate the development of no‐reflow in the pre‐PCI period.  相似文献   

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Evelyn Li Min Tai  Jiunn Loong Ling  Eng Hui Gan  Hussein Adil  Wan-Hitam Wan-Hazabbah 《国际眼科》2018,11(2):274-278

AIM: To compare the peripapillary retinal nerve fiber layer (RNFL) thickness measured via optical coherence tomography (OCT) between different groups of myopia severity and controls.METHODS: This was a prospective cross-sectional study. All subjects underwent a full ophthalmic examination, refraction, visual field analysis and A-scan biometry. Myopic patients were classified as low myopia (LM) [spherical equivalent (SE) from greater than -0.5 D, up to -3.0 D], moderate myopia (MM; SE greater than -3.0 D, up to -6.0 D) and high myopia (HM; SE greater than -6.0 D). The control group consisted of emmetropic (EM) patients (SE from +0.5 D to -0.5 D). A Zeiss Cirrus HD-OCT machine was used to measure the peripapillary RNFL thickness of both eyes of each subject. The mean peripapillary RNFL thickness between groups was compared using both analysis of variance and analysis of covariance.RESULTS: A total of 403 eyes of 403 subjects were included in this study. The mean age was 31.48±10.23y. There were 180 (44.7%) eyes with EM, 124 (30.8%) with LM, 73 (18.1%) with MM and 26 (6.5%) with HM. All groups of myopia severity had a thinner average RNFL than the EM group, but after controlling for gender, age, and axial eye length, only the HM group differed significantly from the EM group (P=0.017). Likewise, the superior, inferior and nasal RNFL was thinner in all myopia groups compared to controls, but after controlling for confounders, only the inferior quadrant RNFL was significantly thinner in the HM group, when compared to the EM group (P=0.017).CONCLUSION: The average and inferior quadrant RNFL is thinner in highly myopic eyes compared to emmetropic eyes. Refractive status must be taken into consideration when interpreting the OCT of myopic patients, as RNFL thickness varies with the degree of myopia.  相似文献   

    

Adil Mehraj Khan  Rajinder Raina  Nitin Dubey  Pawan Kumar Verma 《Drug and chemical toxicology》2018,41(2):123-127

The study evaluated the effect of commercial preparation of deltamethrin, Butox^®, and fluoride (F^?) co-exposure on the brain antioxidant status and cholinesterase activity in rats. Group A was untreated. Group B was gavaged Butox^®, providing deltamethrin at the dose rate of 1.28?mg per kg body weight per day. Group C was administered F^?, as NaF, in drinking water providing 20?ppm F^?. Group D received both deltamethrin and F^? at the same dosages as groups B and C, respectively. Although, glutathione S-transferase activity was induced only in Butox^® alone treated group, the activities of superoxide dismutase and catalase were inhibited in all treatment groups when compared to the control group. Elevated lipid peroxidation was observed in the groups exposed to F^?. The activity of erythrocyte acetylcholinesterase (AChE) was inhibited in Butox^® treated groups, whereas brain AChE activity was inhibited in all treatment groups. In conclusion, both deltamethrin (given as Butox^®) and F^? inhibit AChE activity and produce oxidative stress in brain with F^? producing more oxidative damage. However, compared to the individual exposures, the co-exposure of these chemicals does not produce any exacerbated alteration in these biochemical parameters.  相似文献   

    

Ahmed Elkaryoni  Ghada Abu‐Sheasha  Ahmed M. Altibi  Adil Hassan  Karim Ellakany  Navin C. Nanda 《Echocardiography (Mount Kisco, N.Y.)》2019,36(3):528-536

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Anjani Muthyala  Kelly J. Feuerhak  William S. Harmsen  Subhankar Chakraborty  Kent R. Bailey  Adil E. Bharucha 《Neurogastroenterology and motility》2019,31(7)

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Susrutha Puthanmadhom Narayanan  Mayank Sharma  Joel G. Fletcher  Ronald A. Karwoski  David R. Holmes  Adil E. Bharucha 《Neurogastroenterology and motility》2019,31(7)

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Adil E. Bharucha  Bradley Anderson  Michel Bouchoucha 《Neurogastroenterology and motility》2019,31(2)

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Benoit Combs  Laureline Monteau  Elise Bannier  Virginie Callot  Pierre Labauge  Xavier Ayrignac  Clarisse Carra Dallire  Jean Pelletier  Adil Maarouf  Jerome de Seze  Nicolas Collongues  Christian Barillot  Gilles Edan  Jean Christophe Ferr  Anne Kerbrat 《Journal of magnetic resonance imaging : JMRI》2019,49(6):1777-1785

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Eva Sole Cruz;Etienne Fortanier;Frederic Hilezian;Adil Maarouf;Clémence Boutière;Sarah Demortière;Audrey Rico;Emilien Delmont;Jean Pelletier;Shahram Attarian;Bertrand Audoin; 《European journal of neurology》2024,31(7):e16291

The factors underlying the topography of nitrous oxide (N2O)-induced neurological complications are unknown.  相似文献