全文获取类型
收费全文 | 2171篇 |
免费 | 113篇 |
国内免费 | 6篇 |
专业分类
耳鼻咽喉 | 24篇 |
儿科学 | 19篇 |
妇产科学 | 94篇 |
基础医学 | 327篇 |
口腔科学 | 15篇 |
临床医学 | 201篇 |
内科学 | 374篇 |
皮肤病学 | 22篇 |
神经病学 | 226篇 |
特种医学 | 103篇 |
外科学 | 302篇 |
综合类 | 9篇 |
一般理论 | 2篇 |
预防医学 | 83篇 |
眼科学 | 139篇 |
药学 | 117篇 |
中国医学 | 8篇 |
肿瘤学 | 225篇 |
出版年
2023年 | 18篇 |
2022年 | 37篇 |
2021年 | 42篇 |
2020年 | 34篇 |
2019年 | 38篇 |
2018年 | 43篇 |
2017年 | 25篇 |
2016年 | 54篇 |
2015年 | 51篇 |
2014年 | 83篇 |
2013年 | 103篇 |
2012年 | 130篇 |
2011年 | 152篇 |
2010年 | 95篇 |
2009年 | 100篇 |
2008年 | 154篇 |
2007年 | 144篇 |
2006年 | 137篇 |
2005年 | 160篇 |
2004年 | 135篇 |
2003年 | 149篇 |
2002年 | 136篇 |
2001年 | 34篇 |
2000年 | 22篇 |
1999年 | 27篇 |
1998年 | 19篇 |
1997年 | 23篇 |
1996年 | 16篇 |
1995年 | 12篇 |
1994年 | 12篇 |
1993年 | 6篇 |
1992年 | 13篇 |
1991年 | 13篇 |
1990年 | 5篇 |
1989年 | 7篇 |
1988年 | 4篇 |
1987年 | 4篇 |
1986年 | 4篇 |
1985年 | 5篇 |
1984年 | 4篇 |
1983年 | 5篇 |
1982年 | 8篇 |
1981年 | 4篇 |
1979年 | 2篇 |
1978年 | 4篇 |
1977年 | 5篇 |
1975年 | 2篇 |
1974年 | 3篇 |
1972年 | 2篇 |
1969年 | 2篇 |
排序方式: 共有2290条查询结果,搜索用时 15 毫秒
71.
72.
Christine C. Boucard Josef P. Rauschecker Susanne Neufang Achim Berthele Anselm Doll Andrej Manoliu Valentin Riedl Christian Sorg Afra Wohlschläger Mark Mühlau 《Brain structure & function》2016,221(4):2367-2374
We present a case report on visual brain plasticity after total blindness acquired in adulthood. SH lost her sight when she was 27. Despite having been totally blind for 43 years, she reported to strongly rely on her vivid visual imagery. Three-Tesla magnetic resonance imaging (MRI) of SH and age-matched controls was performed. The MRI sequence included anatomical MRI, resting-state functional MRI, and task-related functional MRI where SH was instructed to imagine colours, faces, and motion. Compared to controls, voxel-based analysis revealed white matter loss along SH’s visual pathway as well as grey matter atrophy in the calcarine sulci. Yet we demonstrated activation in visual areas, including V1, using functional MRI. Of the four identified visual resting-state networks, none showed alterations in spatial extent; hence, SH’s preserved visual imagery seems to be mediated by intrinsic brain networks of normal extent. Time courses of two of these networks showed increased correlation with that of the inferior posterior default mode network, which may reflect adaptive changes supporting SH’s strong internal visual representations. Overall, our findings demonstrate that conscious visual experience is possible even after years of absence of extrinsic input. 相似文献
73.
74.
Comment on ‘Ultrasound assessment of gastric volume in the fasted pediatric patient undergoing upper gastrointestinal endoscopy: development of a predictive model using endoscopically suctioned volumes’
下载免费PDF全文
![点击此处可从《Paediatric anaesthesia》网站下载免费的PDF全文](/ch/ext_images/free.gif)
75.
Ninichuk V Khandoga AG Segerer S Loetscher P Schlapbach A Revesz L Feifel R Khandoga A Krombach F Nelson PJ Schlöndorff D Anders HJ 《The American journal of pathology》2007,170(4):1267-1276
Diabetic nephropathy is associated with interstitial macrophage infiltrates, but their contribution to disease progression is unclear. We addressed this question by blockade of chemokine receptor (CCR)1 because CCR1 mediates the macrophage recruitment to the renal interstitium. In fact, when CCR1 was blocked with BL5923, a novel orally available CCR1 antagonist, the interstitial recruitment of ex vivo labeled macrophages was markedly decreased in uninephrectomized male db/db mice with advanced diabetic nephropathy. Likewise, BL5923 (60 mg/kg, twice a day) orally administered from months 5 to 6 of life reduced the numbers of interstitial macrophages in uninephrectomized db/db mice. This was associated with reduced numbers of Ki-67 proliferating tubular epithelial and interstitial cells, tubular atrophy, and interstitial fibrosis in uninephrectomized db/db mice. Glomerular pathology and proteinuria were not affected by the CCR1 antagonist. BL5923 reduced renal mRNA expression of Ccl2, Ccr1, Ccr2, Ccr5, transforming growth factor-beta1, and collagen I-alpha1 when compared with untreated uninephrectomized male db/db mice of the same age. Thus, we identified a previously unrecognized role for interstitial macrophages for tubulointerstitial injury, loss of peritubular microvasculature, interstitial inflammation, and fibrosis in type 2 diabetic db/db mice. These data identify oral treatment with the CCR1 antagonist BL5923 as a potential therapy for late-stage diabetic nephropathy. 相似文献
76.
Schnake Klaus John Pumberger Matthias Rappert Denis Götz Achim Zolotoverkh Oleksandr Waligora Rita Scheyerer Max Joseph 《European spine journal》2022,31(5):1331-1331
European Spine Journal - 相似文献
77.
Fabian Queissert Tanja Hüsch Alexander Kretschmer Ralf Anding Ruth Kirschner-Hermanns Tobias Pottek Roberto Olianas Alexander Friedl Roland Homberg Jesco Pfitzenmaier Carsten M. Naumann Joanne Nyarangi-Dix Torben Hofmann Achim Rose Josef Schweiger Wilhelm Hübner Hagen Loertzer Ricarda M. Bauer Axel Haferkamp Andres J. Schrader Debates On Male Incontinence -Project 《Neurourology and urodynamics》2020,39(6):1856-1861
78.
Mannion Anne F. Mariaux Francine Reitmeir Raluca Fekete Tamas F. Haschtmann Daniel Loibl Markus Jeszenszky Dezsö Kleinstück Frank S. Porchet François Elfering Achim 《European spine journal》2020,29(8):1935-1952
European Spine Journal - Depression, anxiety, catastrophising, and fear-avoidance beliefs are key "yellow flags" (YFs) that predict a poor outcome in back patients. Most surgeons... 相似文献
79.
Insiya B. Poonawalla Darla E. Kendzor Margaret Tresch Owen Margaret O. Caughy 《Addictive behaviors》2014
Background
Although childhood socioeconomic disadvantage has been linked with adolescent tobacco and alcohol use in cross-sectional research, less is known about the influence of changes in socioeconomic status during childhood. Upward socioeconomic mobility may attenuate the negative influence of earlier socioeconomic disadvantage on health, while downward mobility may counter the health benefits of earlier socioeconomic advantage. This study evaluated the influence of common trajectories of family income during childhood on smoking and alcohol use during adolescence.Methods
Data utilized were part of the 15-year longitudinal Study of Early Child Care and Youth Development. A 5-class trajectory model (two stable, one downward, and two upward income trajectories) was developed previously with this sample (N = 1356). Logistic regression analyses were conducted to determine whether children of the more disadvantaged income trajectories were more likely to engage in tobacco and alcohol use at age 15 relative to those of the most advantaged trajectory.Results
Family income trajectory was significantly associated with ever-smoking (p = .02) and past-year alcohol use at age 15 years (p = .008). Children from the less advantaged trajectories were more likely to have ever-smoked than children of the most advantaged trajectory (all p's < .05). Children of the downwardly mobile trajectory were more likely to have used alcohol within the past year than children of the most advantaged trajectories as well as the most disadvantaged trajectory (all p's < .05).Conclusions
Findings indicate that childhood socioeconomic disadvantage influences adolescent smoking, while downward socioeconomic mobility influences adolescent alcohol use. 相似文献80.
Factorial Design-of-Experiment analyses were applied for conventional and beam oscillation fiber laser cutting of 10 mm thick AISI 304 stainless steel. Considered factors in case of the conventional process with a static beam involve both laser and cutting gas parameters, in particular the laser power, the focal plane position, the cutting gas pressure, the nozzle stand-off distance as well as the nozzle diameter. The conducted trials were evaluated with respect to the achievable cutting speed, the cut kerf geometry and the cut edge roughness. Noticeable correlations between cut edge roughness and cut kerf geometry stimulated the development of a corresponding Computational Fluid Dynamics (CFD) model of the cutting gas flow through the kerf. A specific approach of data synchronization revealed that the experimentally determined roughness values do well correlate with numerically computed values of the backward directed component of the gas-induced shear stress and that the cut kerf geometry as internal process-inherent boundary condition influences relevant cutting characteristics more than controllable external cutting gas parameters. Finally, effects of circular beam oscillation were investigated by an additional factorial analysis considering the laser power, the focal plane position, the oscillation frequency and the oscillation amplitude as factors. The results demonstrate the potential of beam oscillation techniques for quality improvements in laser cutting. 相似文献