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排序方式: 共有1096条查询结果,搜索用时 15 毫秒
71.
Nadege Wesner Louis Drevon Alexis Guedon Jean Baptiste Fraison Salim Trad Jean Emmanuel Kahn Achille Aouba Jerome Gillard Matthieu Ponsoye Thomas Hanslik Clement Gourguechon Eric Liozon Kamel Laribi Julien Rossignol Olivier Hermine Lionel Ads Fabrice Carrat Pierre Fenaux Arsene Mekinian Olivier Fain 《European journal of haematology》2019,102(1):63-69
72.
Gianluca Trifirò MD MSc Antoine Pariente MD PhD Preciosa M. Coloma MD Jan A. Kors PhD Giovanni Polimeni PharmD PhD Ghada Miremont‐Salamé MD Maria Antonietta Catania MD Francesco Salvo MD Anaelle David MD Nicholas Moore MD PhD Achille Patrizio Caputi MD Miriam Sturkenboom PharmD PhD Mariam Molokhia PhD Julia Hippisley‐Cox MD Carlos Diaz Acedo Johan van der Lei MD PhD Annie Fourrier‐Reglat PharmD PhD 《Pharmacoepidemiology and drug safety》2009,18(12):1176-1184
73.
Salvatore Cuzzocrea Giuseppina Costantino Emanuela Mazzon Achille P. Caputi 《Journal of pineal research》1999,27(1):9-14
Abstract: The aim of the present study was to investigate the effect of melatonin on the production of the inflammatory mediator prostaglandins in a model of acute inflammation, carrageenan-induced pleurisy, where prostaglandins are known to play a crucial role. The results show that melatonin (12.5, 25, and 50 mg/kg, intraperitoneally, 15 min before the carrageenan) inhibits the inflammatory response (pleural exudate formation, polymorphonuclear cell infiltration, and prostaglandin production) in a dose-dependent manner. Immunohistochemical examination demonstrated a marked increase in the immunoreactivity to cyclooxygenase-2 (COX-2) in the lungs of carrageenan-treated rats. Pretreatment of carrageenan-treated rats with melatonin (50 mg/kg, intraperitoneally, 15 min before the carrageenan) prevented COX-2 expression. The present results demonstrate that melatonin exerts potent anti-inflammatory effects. Part of these anti-inflammatory effects may be related to a reduction of prostaglandin production during the inflammatory process. 相似文献
74.
75.
Viale M Vannozzi MO Pastrone I Mariggiò MA Zicca A Cadoni A Cafaggi S Tolino G Lunardi G Civalleri D Lindup WE Esposito M 《The Journal of pharmacology and experimental therapeutics》2000,293(3):829-836
Procainamide protects mice bearing P388 leukemic cells against the toxicity of cisplatin without diminishing antitumor activity. The mechanism of action of procainamide protection was investigated both in vitro and in vivo. HPLC studies showed that procainamide forms a complex with cisplatin in vitro that has a UV spectrum similar to that of DPR, a triamine platinum complex that contains procaine as ligand. We report here the effect of the reaction product of cisplatin and procainamide on both cisplatin-induced DNA interstrand cross-links (ISCLs) and on the total DNA platination of isolated DNA. Total DNA platination in vitro of isolated DNA was increased by 113% (P <.01) and 17% (P <.05) after incubation times of 1.75 and 6 h, respectively, compared with products from the reaction of cisplatin with water. Furthermore, the reaction product of cisplatin and procainamide was bound to DNA to a significantly greater extent than was cisplatin itself. ISCLs were decreased by 41% when this drug combination was incubated with DNA for 1.75 h, but no changes were observed after incubation for 6 h. We also examined the influence of the time interval between administration of cisplatin and procainamide on normal kidney injury, the renal distribution and urinary excretion of platinum, and the formation of cisplatin-DNA adducts in renal tissue of Sprague-Dawley rats after i.p. administration of 7.5 mg/kg cisplatin either with or without procainamide. The plasma concentrations of urea and creatinine and kidney histology demonstrated that procainamide provided effective protection in vivo in the rat when administered either simultaneously or at 0.5 and 1 h before or after cisplatin. The protection was accompanied by both higher renal levels of platinum and cisplatin-DNA adducts and by an increase in the formation of ISCLs. Moreover, a dose-dependent reduction of urinary excretion and concentration of platinum was also observed. We propose that procainamide, after accumulation in the kidney, may coordinate with cisplatin to form a less toxic DPR-like complex that renders rats less susceptible to cisplatin-induced toxicity. 相似文献
76.
Pierre?Kalfon Karine?Baumstarck Philippe?Estagnasie Marie-Agnès?Geantot Audrey?Berric Georges?Simon Bernard?Floccard Thomas?Signouret Mohamed?Boucekine Mélanie?Fromentin Martine?Nyunga Achille?Sossou Marion?Venot René?Robert Arnaud?Follin Juliette?Audibert Anne?Renault Ma?té?Garrouste-Orgeas Olivier?Collange Quentin?Levrat Isabelle?Villard Didier?Thevenin Julien?Pottecher René-Gilles?Patrigeon Nathalie?Revel Coralie?Vigne Elie?Azoulay Olivier?Mimoz Pascal?Auquier 《Intensive care medicine》2017,43(12):1829-1840
Purpose
Critically ill patients are exposed to stressful conditions and experience several discomforts. The primary objective was to assess whether a tailored multicomponent program is effective for reducing self-perceived discomfort.Methods
In a cluster-randomized two-arm parallel trial, 34 French adult intensive care units (ICUs) without planned interventions to reduce discomfort were randomized, 17 to the arm including a 6-month period of program implementation followed by a 6-month period without the program (experimental group), and 17 to the arm with an inversed sequence (control group). The tailored multicomponent program consisted of assessment of ICU-related self-perceived discomforts, immediate and monthly feedback to healthcare teams, and site-specific tailored interventions. The primary outcome was the overall discomfort score derived from the 16-item IPREA questionnaire (0, minimal, 100, maximal overall discomfort) and the secondary outcomes were the discomfort scores of each IPREA item. IPREA was administered on the day of ICU discharge with a considered timeframe from the ICU admission until ICU discharge.Results
During a 1-month assessment period, 398 and 360 patients were included in the experimental group and the control group, respectively. The difference (experimental minus control) of the overall discomfort score between groups was ? 7.00 (95% CI ? 9.89 to ? 4.11, p < 0.001). After adjustment (age, gender, ICU duration, mechanical ventilation duration, and type of admission), the program effect was still positive for the overall discomfort score (difference ? 6.35, SE 1.23, p < 0.001) and for 12 out of 16 items.Conclusions
This tailored multicomponent program decreased self-perceived discomfort in adult critically ill patients. Trial Registration: Clinicaltrials.gov Identifier NCT02442934.77.
Ola S. Ahmed Ailín C. Rogers Jarlath C. Bolger Achille Mastrosimone William B. Robb 《Journal of gastrointestinal surgery》2018,22(6):964-972
Background
Enhanced recovery after surgery (ERAS) guidelines, fast-track protocols, and alternative clinical pathways have been widely promoted in a variety of disciplines leading to improved outcomes in post-operative morbidity and length of stay (LOS). This meta-analysis assesses the implications of standardized management protocols in bariatric surgery.Methods
The PRISMA guidelines were adhered to. Databases were searched with the application of pre-defined inclusion and exclusion criteria. Results were reported as mean differences or pooled odds ratios (OR) with 95% confidence intervals (95% CI). Individual protocols and surgical approaches were assessed through subgroup analysis, and sensitivity analysis of methodological quality was performed.Results
A total of 1536 studies were screened; 13 studies were eventually included for meta-analysis involving a total of 6172 patients. Standardized perioperative techniques were associated with a savings of 19.5 min in operative time (p <?0.01), as well as a LOS which was shortened by 1.5 days (p <?0.01). Pooled post-operative morbidity rates also favored enhanced recovery care protocols (OR 0.7%, 95% CI 0.6–0.9%, p <?0.01).Conclusion
Bariatric surgery involves a complex cohort of patients who require high-quality evidence-based care to improve outcomes. Consensus guidelines on the feasibility of ERAS and alternative clinical pathways are required in the setting of bariatric surgery.78.
Casiglia E Mazza A Tikhonoff V Basso G Martini B Scarpa R Pessina AC 《Advances in therapy》2004,21(6):357-369
Manidipine and lercanidipine are considered effective and safe in the treatment of chronic arterial hypertension and are equipotent
in reducing blood pressure (BP) levels. Their main side effect is ankle-foot edema. After a 2-week placebo runin period, these
2 drugs were compared in a controlled parallel-group study lasting 3 months, involving 53 patients with mild-to-moderate essential
hypertension (26 assigned to manidipine and 27 to lercanidipine). At the end of the active treatment period, BP was significantly
reduced in comparison with the end of the placebo phase in both the manidipine and the lercanidipine groups, without significant
differences between the 2 drugs. Daytime BP was significantly reduced by 5.5%/5.6% with manidipine and by 3.8%/6.6% with lercanidipine,
while smaller reductions were seen at nighttime. The smoothness index was the same with both drugs. Unlike lercanidipine,
manidipine significantly reduced both basal (-30%) and minimal vascular resistance (-39%), qualifying it as a potent vasodilator.
Despite vasodilation, heart rate was not increased but was even slightly reduced by treatment. Ankle-foot edema was observed
with both drugs but was less pronounced with manidipine, probably because of greater postcapillary dilatation. In conclusion,
manidipine and lercanidipine are both effective and safe in mild-to-moderate essential hypertension, although the former seems
to have a more favorable tolerability profile than the latter. 相似文献
79.
Adverse drug reactions related to amoxicillin alone and in association with clavulanic acid: data from spontaneous reporting in Italy 总被引:1,自引:0,他引:1
Salvo F Polimeni G Moretti U Conforti A Leone R Leoni O Motola D Dusi G Caputi AP 《The Journal of antimicrobial chemotherapy》2007,60(1):121-126
OBJECTIVES: To analyse an Italian database of spontaneous reporting of suspected adverse drug reactions in order to compare the safety profile of amoxicillin and amoxicillin/clavulanic acid. METHODS: Data were retrieved from the spontaneous reports collected by six Italian regions (the GIF database) from January 1988 to June 2005. Drug utilization data were also available for the two drugs. The comparison between amoxicillin and amoxicillin/clavulanic acid was made using the chi(2) or Student's t-test, when appropriate. Disproportionality in reporting of adverse events was assessed using reporting odds ratio methodology. RESULTS: Up to June 2005, the GIF database collected 37 906 reports, of which 1088 were related to amoxicillin/clavulanic acid and 1095 to amoxicillin. The percentage of skin reactions was statistically higher for amoxicillin (82%) than for amoxicillin/clavulanic acid (76%); on the contrary, the percentage of gastrointestinal, hepatic and haematological reactions was significantly higher for amoxicillin/clavulanic acid (13%, 4% and 2%, respectively) than for amoxicillin (7%, 1% and 1%, respectively). Amoxicillin/clavulanic acid seems to be associated with a higher risk of Stevens-Johnson syndrome, purpura and hepatitis than amoxicillin alone. In particular, the reporting rate of hepatitis is on average 9-fold higher for amoxicillin/clavulanic acid than for amoxicillin. CONCLUSIONS: Analysis shows a different safety profile for the two selected drugs. The combination of amoxicillin/clavulanic acid has been increasingly used in Italy and now represents the most frequently antibiotic prescribed by Italian general practitioners. Given the documented level of inappropriate use of beta-lactams in Italy, these results should be taken into account by physicians before prescribing amoxicillin/clavulanic acid to patients. 相似文献
80.