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101.
CONCLUSION: Evoked otoacoustic emission (OAE) and auditory brainstem response (ABR) results for hearing screening among infants have good concordance. However, good correlation with the Griffiths Developmental Scales remains to be desired. OBJECTIVE: To correlate hearing screening outcomes of a cohort of infants with developmental outcomes at 6 and 12 months. SUBJECTS AND METHODS: A cohort of pregnant women was identified in several communities in a rural area (Bulacan province) from April 2002 to February 2003 as part of a population-based study determining maternal exposure to pollutants and infant outcomes, with a total follow-up of 2 years. Pregnant mothers were identified and followed up until delivery at a secondary, provincial hospital. Hearing screening was performed with OAEs and ABR. Mental development of infants was assessed at 6 and 12 months using Griffiths Mental Developmental Scales - locomotor, personal-social, hearing and speech, hand and eye coordination, performance tests. RESULTS: Among the 1086 babies recruited, there were 724 with hearing assessment. Of these 724 babies, 565 had both OAE testing and ABR. Overall in 1130 ears, OAE and ABR testing showed an observed agreement of 99%, agreement due to chance of 96%, and kappa agreement of 79% (p=0.00) in diagnosing bilateral hearing losses. OAEs had a sensitivity of 86.4% (95% CI 64-96.4%) and a specificity of 99.4% (95% CI 98.6-99.7%). At the end of the study, there were 708/724 (97.8%) infants with normal hearing, 7/724 (1.0%) with unilateral hearing loss, 8/724 (1.1%) with bilateral mild hearing loss, and 1/724 (0.1%) with bilateral profound hearing loss, who demonstrated consistent mental delay throughout. Follow-up rates for developmental examinations at 6 and 12 months were 98% and 81.25%, respectively. In these groups, there were 8 (1%) infants at 6 months and 18 (2.4%) at 12 months with developmental delay (Griffiths Mental Developmental Scales). 相似文献
102.
DONG IL SHIN M.D. KIYUK CHANG M.D. YOUNGKEUN AHN M.D. BYUNG‐HEE HWANG M.D. HUN‐JUN PARK M.D. SEOK MIN SEO M.D. YOON‐SEOK KOH M.D. PUM‐JOON KIM M.D. KI‐BAE SEUNG M.D. MYUNG HO JEONG M.D. 《Journal of interventional cardiology》2014,27(1):12-20
Background
The prognostic impact of occluded culprit arteries in non‐ST‐elevation myocardial infarction (NSTEMI) patients beyond 12 months has not been investigated.Objectives
The impact of occluded culprit arteries on a composite of cardiac death (CD), recurrent nonfatal MI (RMI), and target vessel revascularization (TVR) in patients who presented with NSTEMI was investigated during a 48‐month follow‐up using propensity‐score (PS) matching.Methods
A total of 2,878 NSTEMI patients in the COREA‐AMI (COnvergent REgistry of cAtholic and chonnAm university for Acute MI) Registry were classified according to the angiographic flow of culprit arteries (occlusion [OC], n = 1,070; nonocclusion, n = 1,808). After PS matching, the incidence of the primary end‐point, a composite of CD, RMI, and TVR was compared.Results
The median follow‐up duration was 47.3 months (IQR 32.7–66.2). In the PS‐matched population, the 48‐month cumulative rates of the primary end‐point (27.5% vs. 17.9%, P < 0.001) and each event were higher in the OC group (CD: 9.0% vs. 5.4%, RMI: 16.3% vs. 9.4%, TVR: 10.5% vs. 5.6%, respectively, P < 0.05). In multivariate Cox regression analysis, occluded culprit arteries showed the significant statistical impact on the primary end‐point (HR 1.689 [1.385–2.059], P < 0.001) and each event (CD: 1.736 [1.218–2.475], RMI: 1.918 [1.468–2.505], TVR: 2.042 [1.453–2.869], respectively, P < 0.05). Furthermore, in the 12‐month landmark analysis, occluded culprit arteries were still associated with higher risk of primary end‐point beyond 12 months (P < 0.001).Conclusions
Occluded culprit arteries were independently associated with the higher risk of CD, RMI, and TVR in NSTEMI patients during the 48‐month follow‐up. (J Interven Cardiol 2014;27:12–20)103.
104.
105.
1. Infected material from the brain and spinal cord of an infant suffering from a recently recognized form of granulomatous encephalomyelitis was inoculated into rabbits and mice and produced an experimental disease which was readily transmissible in series. 2. A parasite identical with that in the lesions of the human case was found in the lesions of the experimental animals. 3. The morphology of this microorganism, the course of the disease and the lesions produced in the animals inoculated with it, the wide host range of this parasite, and the results of cross immunity experiments, establish its identity as a Toxoplasma. It is suggested that the microorganism be designated Toxoplasma hominis. 4. The clinical and pathologic features of the infection produced in animals by this Toxoplasma are described. 5. The infection in the infant is the first proved instance of human toxoplasmosis. Since the lesions were confined to the central nervous system the disease is termed toxoplasmic encephalomyelitis. 6. The first experimental transmission of human toxoplasmosis to animals is recorded. 相似文献
106.
Amy Lynn Meadows Justin C. Strickland M. Spencer Kerr Abner O. Rayapati Craig R. Rush 《Substance use & misuse》2019,54(10):1743-1749
Background: Exposure to adverse childhood experiences (ACEs) increases health risk behavior in adulthood and is a risk for premature mortality. For example, ACEs are associated with both tobacco smoking and obesity, which remain significant health challenges for many adults, despite widespread knowledge about the risks. Objective: The present investigation used a novel online crowdsourcing platform (Amazon.com mechanical turk) to study the relationship between ACEs and later tobacco smoking and obesity. Methods: Participants were recruited based on smoking (n?=?74 smokers; n?=?75 nonsmokers) and stratified based on obesity (n?=?52 BMI ≥ 30; n?=?97 BMI < 30). Participants had no recent history of other substance use, except alcohol. The relationship between ACE score and smoking and obesity categories was analyzed using logistic regression. Results: The average age of the sample was 38.6-years old and was mostly female (66.4%), employed (82.6%) and college educated (63.1%). Those with 4+ ACEs had a significantly greater odds of cigarette use. Any ACEs exposure was associated with a significantly greater odds of obesity. Conclusions/Importance: Findings are concordant with previous studies and suggest crowdsourcing is a viable platform for studying ACEs and health behavior. Access to large samples and specific populations provided by crowdsourcing could help examine theoretical models about how exposure to ACEs could be connected to later adoption of high-risk behaviors such as tobacco cigarette smoking and obesity. 相似文献
107.
G. CHUA-TY M.D. C.L. GOH M.R.C.P. S.L. KOH B.A. 《International journal of dermatology》1992,31(8):555-559
At the National Skin Centre, 74,589 new attendances were seen from 1989 to 1990. The M:F ratio was 1:1. The majority of the patients belonged to the 20-39 year age groups (40%). Frequencies of psoriasis (20.4%) and alopecia (17.2%) were higher among Indians; exfoliative dermatitis was higher among Malays (19.72%); and insect bites were higher among Chinese (87%) [P less than 0.05] compared with ethnic distribution (9.9%, 7.6%, and 77.2% respectively) of NSC patient population. Dermatitis (34.2%) and acne (10.9%) were the most common skin disorders seen. The more common dermatoses seen in 1989/90 differ slightly from those reported in 1950s and 1980s; however, the frequencies of contact dermatitis, fungal infection, and insect bite reactions of 5.8%, 10.9%, and 7.6%, respectively, in 1980 have decreased to 4.7%, 5.4%, and 2.3%, respectively, in 1989/90. There was no seasonal variation in the frequency of various dermatoses except for psoriasis, which was more prevalent during the first quarters of 1989 and 1990. Our results showed that the pattern of skin diseases in Singapore is slowly approximating that of developed countries. The changes in the pattern of skin diseases are probably due to improved economic status, better education and hygiene, ready availability of dermatology services, as well as changes in occupational and environmental contactants over the last decade. 相似文献
108.
KOH MIZUNO PhD KATSUMI ASANO PhD KAZUE OKAMOTO MA 《Psychiatry and clinical neurosciences》1998,52(2):137-138
Abstract Six trained male athletes (aged 24.3 ± 2.9 years) performed cycling exercise from 23.00 to 23.50 h. From 00.30 to 07.00 h, the subjects followed a schedule that consisted of 30 min trying to fall asleep in bed and 60 min of being awake outside the bedroom. The control experiment was conducted without exercise under the same time schedule. An increase in rectal temperature induced by exercise was 1.9 ± 0.4. After exercise, prolongation of sleep onset latency was observed only in the sleep period from 00.30 to 01.00 h compared with the control night. Time spent in slow wave sleep throughout the night was significantly longer after exercise. 相似文献
109.
目的:针对直肠癌根治术后复发病例,研究手术与非手术治疗的疗效。方法:642例直肠癌根治手术中,选取其中术后复发的81例进行治疗情况的对照分析研究。结果:两组病例无显著性差异。结论:对直肠癌根治术后复发患者再次手术治疗,与非手术治疗相比,未必能显著提高患者生存率。 相似文献
110.
Bystander activity of Ad-mda7: human MDA-7 protein kills melanoma cells via an IL-20 receptor-dependent but STAT3-independent mechanism. 总被引:9,自引:0,他引:9
Sunil Chada Abner M Mhashilkar Rajagopal Ramesh John B Mumm R Bryan Sutton Dora Bocangel Mingzhong Zheng Elizabeth A Grimm Suhendan Ekmekcioglu 《Molecular therapy》2004,10(6):1085-1095
The melanoma differentiation-associated gene-7 (mda-7/IL24) is a unique member of the IL-10 family of cytokines, with ubiquitous tumor cell proapoptotic activity. Transduction of tumor or normal cells with the mda-7 gene results in secretion of glycosylated MDA-7 protein. Recent data indicate that secreted MDA-7 protein functions as a pro-Th1 cytokine and as a potent antiangiogenic molecule. MDA-7 protein binds two distinct type II cytokine heterodimeric receptor complexes, IL-20R1/IL-20R2 (type 1 IL-20R) and IL-22R1/IL-20R2 (type 2 IL-20R). In this study we analyzed the activity of glycosylated secreted MDA-7 against human melanoma cells. MDA-7 protein induces phosphorylation and nuclear translocation of STAT3 in melanoma cells via both type 1 and type 2 IL-20R. MDA-7 induces dose-dependent cell death in melanoma tumor cells. MDA-7 receptor engagement results in up-regulation of BAX and subsequent apoptosis induction; this effect is mediated by STAT3-independent signaling. Additional IL-10 family members (IL-10, -19, -20, and -22) also activate STAT3; however, these ligands do not activate death pathways in melanoma. In normal cells, MDA-7 can bind to its cognate receptors and induce phosphorylation of STAT3, without cytotoxic sequelae. This study defines a tumor-selective cytotoxic bystander role for secreted MDA-7 protein and identifies a novel receptor-mediated, STAT3-independent, and PKR-independent death pathway. 相似文献