全文获取类型
收费全文 | 296篇 |
免费 | 27篇 |
专业分类
耳鼻咽喉 | 2篇 |
儿科学 | 25篇 |
妇产科学 | 2篇 |
基础医学 | 28篇 |
口腔科学 | 4篇 |
临床医学 | 20篇 |
内科学 | 93篇 |
皮肤病学 | 21篇 |
神经病学 | 15篇 |
外科学 | 52篇 |
综合类 | 8篇 |
预防医学 | 13篇 |
眼科学 | 4篇 |
药学 | 19篇 |
肿瘤学 | 17篇 |
出版年
2023年 | 2篇 |
2022年 | 9篇 |
2021年 | 25篇 |
2020年 | 11篇 |
2019年 | 12篇 |
2018年 | 23篇 |
2017年 | 15篇 |
2016年 | 16篇 |
2015年 | 30篇 |
2014年 | 21篇 |
2013年 | 22篇 |
2012年 | 26篇 |
2011年 | 25篇 |
2010年 | 10篇 |
2009年 | 18篇 |
2008年 | 11篇 |
2007年 | 10篇 |
2006年 | 14篇 |
2005年 | 4篇 |
2004年 | 5篇 |
2003年 | 4篇 |
2001年 | 2篇 |
1994年 | 2篇 |
1992年 | 1篇 |
1991年 | 1篇 |
1986年 | 1篇 |
1984年 | 1篇 |
1981年 | 1篇 |
1918年 | 1篇 |
排序方式: 共有323条查询结果,搜索用时 10 毫秒
21.
Setchell KD Brown NM Desai PB Zimmer-Nechimias L Wolfe B Jakate AS Creutzinger V Heubi JE 《The Journal of nutrition》2003,133(4):1027-1035
The pharmacokinetics of isoflavones in 10 healthy women were determined from serum appearance/disappearance concentration profiles and urinary excretions after single-bolus ingestion of 10, 20 or 40 g of soy nuts delivering increasing amounts of the conjugated forms of daidzein (6.6, 13.2 and 26.4 mg) and genistein (9.8, 19.6 and 39.2 mg). Peak serum daidzein and genistein concentrations were attained after 4-8 h, and elimination half-lives were 8.0 and 10.1 h, respectively. There were no differences in the pharmacokinetics of daidzein and genistein between pre- and postmenopausal women, indicating absorption and disposition of isoflavones to be independent of age or menopausal status. A curvilinear relationship was observed between the bioavailability of daidzein and genistein, apparent from the area under the curve to infinity (AUC(inf)) of the serum concentration-time profiles and the amount of isoflavones ingested. The mean fraction of the isoflavones excreted in urine decreased with increasing intake when expressed as a percentage of the administered dose (63.2 +/- 8.0, 54.4 +/- 8.1 and 44.0 +/- 4.3%, respectively, for daidzein, and correspondingly, 25.2 +/- 5.3, 13.4 +/- 2.1 and 15.8 +/- 2.7% for genistein), underscoring the trend toward nonlinear pharmacokinetics. Equol was identified as a metabolite in 30% of women; it was present consistently in urine and blood from the same subjects. Its delayed appearance was consistent with colonic synthesis. On the basis of the pharmacokinetics, optimum steady-state serum isoflavone concentrations would be expected from modest intakes of soy foods consumed regularly throughout the day rather than from a single highly enriched product. 相似文献
22.
Fetal gastrointestinal malformations 总被引:1,自引:0,他引:1
Dadhwal V Kochhar S Mittal S Kumar S Agarwal S Arora V Barua A 《Indian journal of pediatrics》2001,68(1):27-30
In an audit to evaluate fetal gastrointestinal (GIT) malformations, case sheets of all mothers who gave birth to newborns
with GIT malformations were analysed regarding the maternal history, prenatal ultrasound and the postnatal structural malformations
and perinatal management. In 1999, eleven babies were born with gastrointestinal malformations, one was a still birth. Nine
had associated malformations of other systems, two had trisomy 21. Eight babies were operated in the immediate newborn period,
5 survived. Ultrasound was not very accurate in the diagnosis of GIT anomaly in this series. In view of associated chromosomal
and structural anomaly a fetal ECHO and genetic amniocentesis is warranted. Most of these babies require immediate surgery
after birth, so they need to be delivered in a centre which is equipped with good neonatal and pediatric surgery care. 相似文献
23.
24.
Sahar S. Abdelmoneim Mathieu Bernier Abhijeet Dhoble Stuart Moir Mary E. Hagen Sue Ann C. Ness Patricia A. Pellikka Samir S. Abdel-Kader Sharon L. Mulvagh 《Heart and vessels》2010,25(2):121-130
Myocardial contrast echocardiography (MCE) utilizes compressible microbubbles behaving similarly to red blood cells. Destruction
of microbubbles and observation of the gradual refill into the myocardium are key to evaluating perfusion using real-time
MCE. We aimed to assess the feasibility and diagnostic accuracy of qualitative MCE utilizing a 17-segment model for localization
of myocardial perfusion abnormalities compared with simultaneous technetium-99 m sestamibi single-photon emission computed
tomography (SPECT). From July 2005 through August 2007, 97 patients with known or suspected coronary artery disease underwent
simultaneous SPECT and realtime MCE during adenosine stress. Qualitative MCE and tracer uptake were analyzed visually using
a 17-segment model in a blinded manner. Diagnostic accuracy and 95% confidence interval (CI) were determined. Myocardial contrast
echocardiography was completed in 91 patients (age, mean [SD], 69.3 [10.9] years; body mass index, 30.0 [6.3]; 59 males [65%]).
Myocardial contrast echocardiography analysis was feasible in 88 (97%) patients (261 of 264 [99%] territories; 1299 of 1497
[87%] segments). At patient level, MCE sensitivity was 88% (95% CI, 79%–94%); specificity was 85% (77%–90%). For disease detection
in individual coronary territories, sensitivity and specificity were 84% (71%–92%) and 79% (72%–84%) for the left anterior
descending artery; 62% (38%–80%) and 88% (83%–91%) for the left circumflex artery; and 73% (57%–82%) and 94% (89%–97%) for
the right coronary artery. For MCE combined with wall-motion analysis, concordance with SPECT improved from 80% to 86%. Myocardial
contrast echocardiography interobserver concordance was 81% (κ [SE], 0.611 [0.78]). Myocardial contrast echocardiography accuracy
was comparable in patients classified in accordance with presence of diabetes mellitus, myocardial infarction, hypertension,
or percutaneous coronary intervention. Improved MCE specificity in detecting perfusion defects was seen in patients with no
history of coronary bypass graft surgery (P = 0.005). Real-time MCE with a 17-segment model for analysis has good feasibility and accuracy in evaluation of myocardial
perfusion during adenosine stress. 相似文献
25.
26.
Temporal neurotransmitter conditioning restores the functional activity of adult spinal cord neurons in long-term culture 总被引:1,自引:0,他引:1
The ability to culture functional adult mammalian spinal cord neurons represents an important step in the understanding and treatment of a spectrum of neurological disorders including spinal cord injury. Previously, the limited functional recovery of these cells, as characterized by a diminished ability to initiate action potentials and to exhibit repetitive firing patterns, has arisen as a major impediment to their physiological relevance. In this report, we demonstrate that single temporal doses of the neurotransmitters serotonin, glutamate (N-acetyl-DL-glutamic acid) and acetylcholine-chloride lead to the full electrophysiological functional recovery of adult mammalian spinal cord neurons, when they are cultured under defined serum-free conditions. Approximately 60% of the neurons treated regained their electrophysiological signature, often firing single, double and, most importantly, multiple action potentials. 相似文献
27.
28.
Ankylosing Spondylitis poses significant challenges in terms of early diagnosis, assessment of disease activity, predicting response to the treatment and monitoring radiographic progression. With better understanding of underlying immunopathogenesis, effective targeted therapies are available which improve symptoms, quality of life and possibly slow the radiographic progression. There has been a growing interest in the discovery of biomarkers for defining various aspects of disease assessment and management in Ankylosing Spondylitis. The C‐reactive protein and HLA‐B27 are most commonly used biomarkers. This review describes many other newer biomarkers which have potential clinical applications in this chronic inflammatory disease. 相似文献
29.
30.
Mohan Kundal Abhijeet Saha N.K. Dubey Kanika Kapoor Trayambak Basak Gaurav Bhardwaj Vinay Singh Tanwar Shantanu Sengupta Vinita Batra Ashish Dutt Upadhayay Ajay Bhatt 《CTS Clinical and Translational Science》2014,7(2):132-136