全文获取类型
收费全文 | 1158篇 |
免费 | 70篇 |
国内免费 | 4篇 |
专业分类
耳鼻咽喉 | 4篇 |
儿科学 | 124篇 |
妇产科学 | 31篇 |
基础医学 | 101篇 |
口腔科学 | 29篇 |
临床医学 | 83篇 |
内科学 | 250篇 |
皮肤病学 | 18篇 |
神经病学 | 33篇 |
特种医学 | 109篇 |
外科学 | 146篇 |
综合类 | 84篇 |
预防医学 | 84篇 |
眼科学 | 4篇 |
药学 | 80篇 |
中国医学 | 16篇 |
肿瘤学 | 36篇 |
出版年
2023年 | 8篇 |
2022年 | 20篇 |
2021年 | 25篇 |
2020年 | 24篇 |
2019年 | 25篇 |
2018年 | 29篇 |
2017年 | 28篇 |
2016年 | 31篇 |
2015年 | 27篇 |
2014年 | 39篇 |
2013年 | 64篇 |
2012年 | 61篇 |
2011年 | 75篇 |
2010年 | 33篇 |
2009年 | 38篇 |
2008年 | 52篇 |
2007年 | 51篇 |
2006年 | 42篇 |
2005年 | 41篇 |
2004年 | 36篇 |
2003年 | 33篇 |
2002年 | 36篇 |
2001年 | 19篇 |
2000年 | 24篇 |
1999年 | 22篇 |
1998年 | 14篇 |
1997年 | 43篇 |
1996年 | 16篇 |
1995年 | 11篇 |
1994年 | 16篇 |
1993年 | 7篇 |
1992年 | 7篇 |
1991年 | 6篇 |
1990年 | 12篇 |
1989年 | 16篇 |
1988年 | 21篇 |
1987年 | 27篇 |
1986年 | 26篇 |
1985年 | 16篇 |
1984年 | 10篇 |
1983年 | 9篇 |
1982年 | 10篇 |
1981年 | 11篇 |
1980年 | 10篇 |
1979年 | 17篇 |
1978年 | 10篇 |
1977年 | 6篇 |
1974年 | 4篇 |
1972年 | 4篇 |
1971年 | 4篇 |
排序方式: 共有1232条查询结果,搜索用时 15 毫秒
31.
32.
Susanne Abdulla Judith Machts Jörn Kaufmann Karina Patrick Katja Kollewe Reinhard Dengler Hans-Jochen Heinze Susanne Petri Stefan Vielhaber Peter J. Nestor 《Neurobiology of aging》2014
There is increasing appreciation of non-motor system involvement in amyotrophic lateral sclerosis (ALS), although its full extent and clinical significance remains to be established. This study tested the hypothesis that memory impairment in patients with ALS is related to hippocampal degeneration. Consecutive patients with ALS (58) and 29 matched controls participated in standardized neuropsychological assessment and magnetic resonance imaging. Patients with ALS performed worse in global cognitive functioning and executive and verbal memory tests (p < 0.05). The hippocampus was manually segmented in each hemisphere, and volumes were calculated with correction for intracranial volume. Analysis of covariance, controlled for the effect of age and education years, showed significantly smaller hippocampal volume on the right (p = 0.004) in patients with ALS. Verbal memory test performance correlated with the left hippocampal volume in patients with ALS (p < 0.05), although there was no significant correlation with tests of executive function and clinical variables underscoring the specificity of the present findings. Hippocampal volume loss and its correlation with the severity of verbal memory impairment highlight significant hippocampal involvement which can occur as a non-motor deficit in patients with ALS. 相似文献
33.
34.
35.
36.
37.
38.
Grossman RI; Braffman BH; Brorson JR; Goldberg HI; Silberberg DH; Gonzalez- Scarano F 《Radiology》1988,169(1):117-122
Thirteen patients with definite multiple sclerosis (MS), studied 16-24 months previously with magnetic resonance (MR) imaging with and without enhancement by intravenously administered gadolinium diethylenetriaminepentaacetic acid (DTPA) dimeglumine, were reexamined with a similar protocol. Assessment of enhancement and clinical activity in both studies revealed that enhancement was observed in 13 of 14 cases in which clinical activity had changed within 4 weeks of the study and thus appeared more sensitive than clinical examination in determining active disease. The 3-minute postinjection, short repetition time image (TR) was the most efficient for depicting enhancement. Enhancing lesions (active plaques) arose from previously hyper- or isointense regions on long TR images. Previously active lesions reverted to areas of iso- or hyperintensity on long TR images. Serial comparison of long TR images in this population reveals a decrease in high-intensity lesions on long TR images in some cases and an increase in others. The findings of high-intensity regions on long TR images and previously enhancing lesions both becoming isointense suggests that transient inflammatory changes with concomitant edema without demyelination and/or with significant remyelination may occur in some MS lesions. MS lesions are dynamic; both active and inactive lesions may show dramatic change on longitudinal MR imaging studies. 相似文献
39.
Watad Abdulla Quaresma Mariana Bragazzi Nicola Luigi Cervera Ricard Tervaert Jan Willem Cohen Amital Howard Shoenfeld Yehuda 《Clinical rheumatology》2018,37(2):483-493
Clinical Rheumatology - The autoimmune/inflammatory syndrome induced by adjuvants (ASIA) is a recently identified condition in which the exposure to an adjuvant leads to an aberrant autoimmune... 相似文献
40.
First rotavirus vaccine licensed: Is there really a need? 总被引:6,自引:0,他引:6
RI Glass JS Bresee UD Parashar RC Holman JR Gentsch 《Acta paediatrica (Oslo, Norway : 1992)》1999,88(S426):2-8
The first rotavirus vaccine was licensed in the United States on 31 August 1998 for the prevention of severe rotavius diarrhea in children. Despite this landmark in new vaccines, many pediatricians and public health professionals in Europe are uncertain of the need for this vaccine for the routine immunization of infants. In Europe, ample evidence suggests that rotavirus is the most common cause of hospitalizations for severe diarrhea among children, but proper studies documenting the disease burden of rotavirus or th cost-effectiveness of a rotavirus immunization program have only been conducted in the United Kingdom following epidemiologic models used in the United States. All children are infected with rotavirus during their first few years of life, 30-50% of diarrheal hospitalizations among children <5 years are due to this agent, and, by the age of 5 years, between 1 in 40 and 1 in 77 children in Europe and the United States may be hospitalized for rotavirus. The first vaccine is a live, oral preparation combining four different serotypes of rotavirus and administered in three doses with other childhood immunizations. The good efficacy against severe rotavirus diarrhea, the low risk of adverse side effects and the positive costeffectiveness equation have led the two major immunization advisory groups in the U.S. to recommend this vaccine for routine use in American infants. European physicians and policymakers should re-examine the epidemiology and disease burden of rotavirus diarrhea now that an effective method of prevention is at hand. □ Childhood immunization, diseases, rotavirus, vaccination . 相似文献