全文获取类型
收费全文 | 4079篇 |
免费 | 289篇 |
国内免费 | 24篇 |
专业分类
耳鼻咽喉 | 31篇 |
儿科学 | 153篇 |
妇产科学 | 115篇 |
基础医学 | 458篇 |
口腔科学 | 95篇 |
临床医学 | 335篇 |
内科学 | 921篇 |
皮肤病学 | 62篇 |
神经病学 | 337篇 |
特种医学 | 132篇 |
外国民族医学 | 5篇 |
外科学 | 726篇 |
综合类 | 117篇 |
一般理论 | 1篇 |
预防医学 | 280篇 |
眼科学 | 73篇 |
药学 | 278篇 |
中国医学 | 33篇 |
肿瘤学 | 240篇 |
出版年
2023年 | 38篇 |
2022年 | 95篇 |
2021年 | 152篇 |
2020年 | 100篇 |
2019年 | 119篇 |
2018年 | 149篇 |
2017年 | 89篇 |
2016年 | 108篇 |
2015年 | 121篇 |
2014年 | 173篇 |
2013年 | 197篇 |
2012年 | 270篇 |
2011年 | 303篇 |
2010年 | 188篇 |
2009年 | 163篇 |
2008年 | 201篇 |
2007年 | 213篇 |
2006年 | 211篇 |
2005年 | 250篇 |
2004年 | 190篇 |
2003年 | 177篇 |
2002年 | 156篇 |
2001年 | 74篇 |
2000年 | 69篇 |
1999年 | 81篇 |
1998年 | 25篇 |
1997年 | 26篇 |
1996年 | 16篇 |
1995年 | 28篇 |
1994年 | 16篇 |
1993年 | 19篇 |
1992年 | 29篇 |
1991年 | 18篇 |
1990年 | 26篇 |
1989年 | 20篇 |
1988年 | 18篇 |
1987年 | 17篇 |
1986年 | 23篇 |
1985年 | 21篇 |
1984年 | 15篇 |
1983年 | 14篇 |
1982年 | 15篇 |
1981年 | 11篇 |
1979年 | 12篇 |
1978年 | 20篇 |
1976年 | 10篇 |
1973年 | 10篇 |
1972年 | 13篇 |
1969年 | 15篇 |
1966年 | 9篇 |
排序方式: 共有4392条查询结果,搜索用时 15 毫秒
91.
Lucie Dardevet Dipti Rani Tarek Abd El Aziz Ingrid Bazin Jean-Marc Sabatier Mahmoud Fadl Elisabeth Brambilla Michel De Waard 《Toxins》2015,7(4):1079-1101
Chlorotoxin is a small 36 amino-acid peptide identified from the venom of the scorpion Leiurus quinquestriatus. Initially, chlorotoxin was used as a pharmacological tool to characterize chloride channels. While studying glioma-specific chloride currents, it was soon discovered that chlorotoxin possesses targeting properties towards cancer cells including glioma, melanoma, small cell lung carcinoma, neuroblastoma and medulloblastoma. The investigation of the mechanism of action of chlorotoxin has been challenging because its cell surface receptor target remains under questioning since two other receptors have been claimed besides chloride channels. Efforts on chlorotoxin-based applications focused on producing analogues helpful for glioma diagnosis, imaging and treatment. These efforts are welcome since gliomas are very aggressive brain cancers, close to impossible to cure with the current therapeutic arsenal. Among all the chlorotoxin-based strategies, the most promising one to enhance patient mean survival time appears to be the use of chlorotoxin as a targeting agent for the delivery of anti-tumor agents. Finally, the discovery of chlorotoxin has led to the screening of other scorpion venoms to identify chlorotoxin-like peptides. So far several new candidates have been identified. Only detailed research and clinical investigations will tell us if they share the same anti-tumor potential as chlorotoxin. 相似文献
92.
93.
94.
95.
The role played by host-pathogen interactions in regulation of expression of streptococcal virulence factors in vivo is beginning to become clear. We have reported that the expression of 2 streptococcal virulence factors, the streptococcal pyrogenic exotoxin (Spe) A and the cysteine protease SpeB, was reciprocally modulated during infection with Streptococcus pyogenes. To identify host signals mediating this reciprocal regulation, we cocultured clonal M1T1 isolates with human peripheral blood mononuclear cells (PBMCs). In accordance with our in vivo findings, when bacteria were in direct contact with human PBMCs or were separated in transwells, expression of speA was induced, whereas expression of speB was down-regulated. This phenomenon was mediated by transferrin and lactoferrin and was influenced by the iron-saturation status of these proteins. Iron chelation from media induced expression of speA, but to a much lesser degree than did that with apotransferrin and lactoferrin, suggesting additional effects of these ferrins on modulation of expression of speA and speB. Thus, ferrins may play an important role in host-pathogen interactions in skin and mucosal tissues. 相似文献
96.
97.
98.
Courtney E. Takahashi Ansgar M. Brambrink Michael F. Aziz Elizabeth Macri Joshua Raines Anmol Multani-Kohol Holly E. Hinson Helmi L. Lutsep Wayne M. Clark Jeremy D. Fields 《Neurocritical care》2014,20(2):202-208
Background
General anesthesia (GA) for acute stroke interventions may be associated with inferior functional outcomes. Our goal was to identify physiologic parameters that mediate this association.Methods
Consecutive patients treated at our institution between August 2007 and December 2010 were identified from a prospective database. Clinical data were then extracted by retrospective chart review. Variables significantly associated with outcome in univariate analysis were also examined in multivariate analysis, controlling for well-established prespecified predictors of functional outcome.Results
Of the 106 patients identified, 20 were excluded (17 due to the absence of 90-day mRS and 3 due to insufficient anesthetic records). Blood pressure (BP) decreased significantly after induction of GA, but there was no association between BP and outcome. End tidal carbon dioxide values (ETCO2) at 60 and 90 min, however, were significantly associated with outcomes in both univariate and multivariate analyses. Mean ETCO2 in patients with favorable outcomes (modified Rankin Scale (mRS) 0–3) was higher than in those with unfavorable outcomes (mRS 4–6): 35.2 mmHg versus 32.2 (p = 0.03) at 60 min and 34.9 versus 31.9 (p = 0.04) at 90 min. The adjusted odds ratios for poor outcomes for each 1 mmHg decrease in ETCO2 were the same: 0.76 (95 % CI 0.65–0.92; p = 0.004) at 60 min and 0.76 (95 % CI 0.61–0.93; p = 0.01) at 90 min.Conclusions
While BP decreased significantly in patients undergoing GA for acute stroke intervention, it did not correlate with patient outcome. Decreases in ETCO2 at 30 and 60 min, however, were associated with 90-day mRS. 相似文献99.
Hassan Awada Reda Z. Mahfouz Jibran Durrani Ashwin Kishtagari Deepa Jagadeesh Alan E. Lichtin Brian T. Hill Betty K. Hamilton Hetty E. Carraway Aziz Nazha Navneet S. Majhail Ronald Sobecks Valeria Visconte Matt Kalaycio Mikkael A. Sekeres Jaroslaw P. Maciejewski 《British journal of haematology》2020,189(2):318-322
T-cell large granular lymphocytic leukaemia (T-LGLL) is a chronic clonal lymphoproliferative disorder of cytotoxic T lymphocytes which commonly occurs in older patients and is often associated with autoimmune diseases. Among 246 patients with T-LGLL seen at our institution over the last 10 years, we encountered 15 cases following solid organ or haematopoietic stem cell transplantation. Here, we studied the clinical characterization of these cases and compared them to de novo T-LGLL. This experience represented a clear picture of the intricate nature of the disease manifestation and the complexities of several immune mechanisms triggering the clonal expansion. 相似文献
100.