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排序方式: 共有413条查询结果,搜索用时 15 毫秒
21.
Hagenaars T Gussenhoven EJ Kranendonk SE Blankensteijn JD Honkoop J van der Linden E van der Lugt A 《Cardiovascular drugs and therapy / sponsored by the International Society of Cardiovascular Pharmacotherapy》2000,14(6):635-641
The purpose of this study was to compare the vascular response seen with intravascular ultrasound (IVUS) at 1-year follow-up between statin-treated and non–statin-treated patients. Patients (n=10) undergoing percutaneous transluminal angioplasty (PTA) of the femoropopliteal artery were studied with IVUS immediately after PTA and at 1-year follow-up. In nondilated matched vascular segments, the change in lumen, vessel, and plaque volume was assessed. In balloon-dilated matched vascular segments, the change in lumen, vessel, and plaque area was assessed. A comparison was made between statin-treated (n=5) and non–statin-treated patients (n=5) in lumen, vessel, and plaque changes. At follow-up, both statin-treated and non–statin-treated patients showed a similar increase in plaque volume at the nondilated segment (+4% and +2%, respectively). In statin-treated patients the plaque volume increase was compensated by an increase in vessel volume (+2%), resulting in an increase in lumen volume (+1%). In non–statin-treated patients, on the other hand, the increase in plaque volume was associated with a decrease in vessel volume (–2%), resulting in a decrease in lumen volume (–4%). At the balloon-dilated segment a similar trend in changes of lumen, vessel, and plaque was encountered. Differences between both groups of patients were not statistically significant. Despite the nonsignificant nature of the observation, this small retrospective IVUS study may generate the hypothesis that statin therapy may contribute to superior long-term lumen dimensions by inducing positive vascular remodeling both in nondilated and balloon-dilated vascular segments. 相似文献
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Caroline K L Schraa-Tam Aad van der Lugt Marion Smits Maarten A Frens P C A van Broekhoven Josef N van der Geest 《Journal of neuroimaging》2008,18(2):158-167
BACKGROUND AND PURPOSE: Optokinetic eye movements are elicited when tracking a moving pattern. It can be argued that a moving pattern of stripes invokes both the optokinetic and the smooth pursuit eye movement system, which may confound the observed brain activation patterns using functional magnetic resonance imaging (fMRI). A moving pattern of limited-lifetime-dot stimulation does not target the smooth pursuit eye movement system. METHODS: fMRI was used to compare the cortical activity elicited by an optokinetic eye movement response evoked by a moving pattern of stripes and a moving pattern of limited lifetime dots. RESULTS: The eye movement behavior showed that both types of stimuli evoked an adequate and similar optokinetic eye movement response, but stimulation with stripes evoked more activation in the frontal and parietal eye fields, MT/V5, and in the cerebellar area VI than stimulation with limited-lifetime dots. CONCLUSIONS: These brain areas are implicated in smooth pursuit eye movements. Our results suggest that indeed both the optokinetic and the smooth pursuit eye movement system are involved in tracking a moving pattern of stripes. 相似文献
24.
Daniel TP Fong Mak-Ham Lam Miko LM Lao Chad WN Chan Patrick SH Yung Kwai-Yau Fung Pauline PY Lui Kai-Ming Chan 《Journal of orthopaedic surgery and research》2008,3(1):7
Background
Excessive pronation (or eversion) at ankle joint in heel-toe running correlated with lower extremity overuse injuries. Orthotics and inserts are often prescribed to limit the pronation range to tackle the problem. Previous studies revealed that the effect is product-specific. This study investigated the effect of medial arch-heel support in inserts on reducing ankle eversion in standing, walking and running. 相似文献25.
Gerda Drent Elizabeth B. Haagsma Sabina De Geest Aad P. van den Berg Els M. Ten Vergert Hillegonda J. van den Bosch Maarten J. H. Slooff Jan H. Kleibeuker 《Transplant international》2005,18(8):960-966
Limited evidence is available concerning (non)compliance with the immunosuppressive regimen in adult liver transplant recipients. In our study we prospectively assessed prednisolone (non)compliance in 108 adult liver transplant recipients using electronic event monitoring (EEM) in an outpatient setting. The EEM is a pill bottle fitted with a cap containing a microelectronic circuit that registers date and time of bottle openings and closings. Median taking compliance was 100% (range 60-105%), median dosing compliance was 99% (range 58-100%); median timing compliance (TIC) was 94% (42-100%). A drug holiday (DH) of > or =48 h was found in 39% of the patients of > or =72 h in 16% of the patients. Using EEM in liver transplant recipients, we found an overall high level of compliance for prednisolone, except that TIC was low in about one third of the patients. Age below 40 years was found a significant risk factor for decreased TIC and for DHs of > or =48 h. 相似文献
26.
Summary We extend the hidden Markov Model for defaults of Crowder et al. (2005, Quantitative Finance 5, 27–34) to include covariates. The covariates enhance the prediction of transition probabilities from high to low default regimes. To estimate the model, we extend the EM estimating equations to account for the time varying nature of the conditional likelihoods due to sample attrition and extension. Using empirical U.S. default data, we find that GDP growth, the term structure of interest rates and stock market returns impact the state transition probabilities. The impact, however, is not uniform across industries. We only find a weak correspondence between industry credit cycle dynamics and general business cycles. 相似文献
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Sonography of a patient with acute upper abdominal pain demonstrated an encapsulated hyperechoic mass which indented the stomach. Fine-needle biopsy produced atypical cells; the diagnosis of nodular intra-abdominal panniculitis was made at surgery. Sonography probably has a role in the detection and follow-up of this benign lesion. 相似文献
29.
The recombinant 70 kDa heat-shock protein of Mycobacterium avium subspecies paratuberculosis (MAP Hsp70) has been shown to be an immunodominant antigen and a subunit vaccine candidate for bovine paratuberculosis. The aim of the present study was to define MAP Hsp70 specific T cell epitopes in cows immunized with MAP Hsp70 and cows experimentally infected with MAP. Nine peptides were shown to induce proliferation and interferon-γ production by lymphocytes from MAP Hsp70 immunized cattle. From 28 calves experimentally infected with MAP 82% responded to at least one of the 5 most immunodominant peptides, indicating relevance of the epitopes during infection. In these 28 animals 15 different BoLA class II haplotypes were present indicating that the peptides were presented by multiple BoLA class II DRB3 alleles. These findings indicate the potential of the MAP Hsp70 subunit vaccine as a tool to control paratuberculosis in outbred cattle populations. 相似文献
30.
Paula van Dommelen Mathisca de Gunst Aad van der Vaart Stef van Buuren Dorret Boomsma 《Acta paediatrica (Oslo, Norway : 1992)》2008,97(8):1099-1104
AIM: To determine the size of the growth deficit in Dutch monozygotic and dizygotic twins aged 0-2.5 years as compared to singletons and to construct reference growth charts for twins. METHODS: Growth of twins was studied using longitudinal data on over 4000 twins aged 0-2.5 years of the Netherlands Twin Register. The LMS method was used to obtain growth references for length/height, weight, and body mass index (BMI) for twins. RESULTS: During the first 2.5 years of age, differences in length/height and weight between twins and singletons decrease but do not disappear. BMI of twins deviates less than that of singletons. Approximately half of the growth retardation from birth until 1.5 years of age was attributable to gestational age. Between 1.5 years and 2.5 years of age, this difference was reduced to one-third. Thus, a substantial part of the growth difference could not be explained by gestational age. CONCLUSIONS: During the first 2.5 years of life, there is a difference in growth between twins and singletons. Twins catch up in their body size, i.e. they grow faster after birth, but do not yet achieve the same height and weight till they reach 2.5 years of age. We recommend the use of the growth references for twins. 相似文献