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Buth J van Marrewijk CJ Harris PL Hop WC Riambau V Laheij RJ;EUROSTAR Collaborators 《Journal of vascular surgery》2002,35(2):211-221
OBJECTIVE: Endovascular abdominal aortic aneurysm repair (EAR) can be performed in patients whose conditions were previously considered unfit for conventional treatment of the aneurysm. However, because the life span in this category of patients often is limited because of serious comorbidity, the efficacy of EAR in prolonging life expectancy remains uncertain. This study involves the evaluation of preoperative risk classification and an assessment of the outcome of interventions. METHODS: The data of 3075 patients, who underwent operation in 101 European institutions that collaborated in the EUROSTAR Registry, were assessed. Only the patients who had been prospectively enrolled in the registry were used for this analysis. Patient characteristics, operative risk factors, procedural details, and types of devices were correlated with preoperative estimates of operative risk, early and late mortality, complications, and primary and secondary outcome success rates. In addition, the intermediate-term survival rates in patients with unfit conditions with EAR (observed series) and with conservative approaches of the aneurysms (rupture rates as derived from the literature) were compared in a mathematical model. RESULTS: Of the overall study group, 2525 patients were at "normal" risk for a surgical procedure (group A), 399 patients had conditions that were considered unfit for open surgery (group B), and 151 patients had conditions that were unfit for general anesthesia (group C). Both unfit categories had significantly more comorbid factors and larger aneurysms than did the patients in good medical condition. Differences were observed in comorbidities between the two high-risk categories, groups B and C. Factors that influenced the abdominal approach (previous laparotomies, hostile abdomen, and obesity) and local anatomic factors (eg, retroperitoneal fibrosis, inflammatory aneurysm, dissections, and enterostomy) were present in 19% of the patients with conditions that were unfit for open surgery and in only 1% of the category unfit for anesthesia. In contrast, severe pulmonary disease was present in 33% of the patients with conditions that were unfit for anesthesia as opposed to 11% of the patients with conditions that were unfit for open surgery. The early and late mortality rates were significantly higher in the unfit categories (groups B and C). Life table results showed a 3-year survival rate of 83% in patients at normal operative risk and of 68% in patients with unfit conditions (P =.0001). An independent correlation with late death was shown for the clinical classification into high-risk groups B and C, pulmonary disease, team experience of less than 60 procedures, and the diameter of the aneurysm. In groups B and C, aneurysms smaller than 6.0 cm were associated with a 2-year survival rate of 80% and larger aneurysms with a rate of 68% (P =.02). This difference was caused by an increased non-aneurysm-related mortality rate in the group with aneurysms of more than 6 cm. The mathematical model showed an advantage of EAR with regard to the reduction of the death rate in patients with unfit conditions as compared with no intervention after 1 year. The advantage of EAR was observed in patients with AAAs between 5 and 6 cm and with larger aneurysms. CONCLUSION: Early and late mortality rates were increased in patients with the preoperative clinical diagnosis "unfit for open surgery and general anesthesia" as compared with patients at "normal" operative risk. EAR appeared of potential benefit in patients with unfit conditions, regardless of the aneurysm diameter. The life expectancy of patients at high risk who are considered for EAR should be longer than 1 year before any realistic gain in life span can be anticipated. 相似文献
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Rochelle Frounfelker Stephen E. Gilman Sergio Aguilar-Gaxiola Jordi Alonso Evelyn J. Bromet Ronny Bruffaerts Giovanni de Girolamo Semyon Gluzman Oye Gureje Elie G. Karam Sing Lee Jean-Pierre Lépine Yutaka Ono Beth-Ellen Pennell Daniela G. Popovici Margreet ten Have Ronald C. Kessler On behalf of the WHO World Mental Health Survey Collaborators 《Social psychiatry and psychiatric epidemiology》2018,53(2):207-219
Purpose
Understanding the effects of war on mental disorders is important for developing effective post-conflict recovery policies and programs. The current study uses cross-sectional, retrospectively reported data collected as part of the World Mental Health (WMH) Survey Initiative to examine the associations of being a civilian in a war zone/region of terror in World War II with a range of DSM-IV mental disorders.Methods
Adults (n?=?3370) who lived in countries directly involved in World War II in Europe and Japan were administered structured diagnostic interviews of lifetime DSM-IV mental disorders. The associations of war-related traumas with subsequent disorder onset-persistence were assessed with discrete-time survival analysis (lifetime prevalence) and conditional logistic regression (12-month prevalence).Results
Respondents who were civilians in a war zone/region of terror had higher lifetime risks than other respondents of major depressive disorder (MDD; OR 1.5, 95% CI 1.1, 1.9) and anxiety disorder (OR 1.5, 95% CI 1.1, 2.0). The association of war exposure with MDD was strongest in the early years after the war, whereas the association with anxiety disorders increased over time. Among lifetime cases, war exposure was associated with lower past year risk of anxiety disorders (OR 0.4, 95% CI 0.2, 0.7).Conclusions
Exposure to war in World War II was associated with higher lifetime risk of some mental disorders. Whether comparable patterns will be found among civilians living through more recent wars remains to be seen, but should be recognized as a possibility by those projecting future needs for treatment of mental disorders.106.
Andrea Mari Riccardo Campi Riccardo Schiavina Daniele Amparore Alessandro Antonelli Walter Artibani Maurizio Barale Roberto Bertini Marco Borghesi Pierluigi Bove Eugenio Brunocilla Umberto Capitanio Luigi Da Pozzo Julian Daja Paolo Gontero Alessandro Larcher Vincenzo Li Marzi Nicola Longo Vincenzo Mirone Emanuele Montanari Francesca Pisano Francesco Porpiglia Claudio Simeone Salvatore Siracusano Riccardo Tellini Carlo Trombetta Alessandro Volpe Vincenzo Ficarra Marco Carini Andrea Minervini Collaborators 《BJU international》2019,124(1):93-102
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Laura Campbell-Sills Ph.D. Ronald C. Kessler Ph.D. Robert J. Ursano M.D. Anthony J. Rosellini Ph.D. Tracie O. Afifi Ph.D. Lisa J. Colpe Ph.D. M.P.H. Steven G. Heeringa Ph.D. Matthew K. Nock Ph.D. Nancy A. Sampson B.A. Jitender Sareen M.D. Michael Schoenbaum Ph.D. Xiaoying Sun M.S. Sonia Jain Ph.D. Murray B. Stein M.D. M.P.H. the Army STARRS Collaborators 《Depression and anxiety》2017,34(8):701-710
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Prognostic significance of proteinuria in stroke patients treated with intravenous thrombolysis
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H. Gensicke D. Strbian A. Zini A. Pezzini V. Padjen M. Haueter D. J. Seiffge L. M?kitie C. Traenka L. Poli N. Martinez‐Majander J. Putaala L. H. Bonati G. Sibolt G. Giovannini S. Curtze L. Beslac‐Bumbasirevic L. Vandelli P. A. Lyrer P. J. Nederkoorn T. Tatlisumak S. T. Engelter the Thrombolysis in Stroke Patients Collaborators 《European journal of neurology》2017,24(2):262-269
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Gathani T Green J Reeves G Beral V;Million Women Study Collaborators 《Journal of clinical epidemiology》2008,61(4):402-406
OBJECTIVE: Extracting complete and accurate records of surgical procedures from case-notes is time consuming and laborious. We compared the completeness and time taken to extract data on surgical procedures from case-notes and from pathology reports. STUDY DESIGN AND SETTING: Information on surgical procedures was extracted from pathology reports and hospital case-notes for 111 women with breast cancer in three centers. The time taken to perform this task was recorded. Surgical procedures were classified into diagnostic and therapeutic procedures, and analysis was performed to determine the completeness and accuracy of the documentation of the procedures. RESULTS: The average time taken to extract relevant information from the pathology reports (3.0 minutes) was one-fifth that for the case-notes (14.4 minutes). The case-notes documented slightly fewer procedures than the pathology records: 94 vs. 108 diagnostic and 108 vs. 110 therapeutic procedures, respectively. Of the 219 therapeutic and diagnostic surgical procedures recorded by both data sources, for 216 procedures there was exact agreement as to the specific type of procedure performed. CONCLUSIONS: Extraction of information on surgical procedures is faster from pathology records than from case-notes. The level of agreement for the specific type of procedure performed is excellent and, if anything, the pathology records are more complete than the case-notes. 相似文献
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