Determination of serum soluble macrophage colony-stimulating factor receptor levels in patients with hematological diseases

Many cytokine receptors are synthesized as secreted soluble forms. The soluble receptors are created either by proteolytic cleavage of membrane-bound receptor to release extracellular portion, or by alternative mRNA splicing. Soluble cytokines exert their effects through the action of competing with membrane-bound receptors for binding to their ligand, or the formation of ligand- receptor complex to protect the ligand from degradation and contribute to the enhanced half-life of the ligand. In…     

一组抗髓细胞单克隆抗体的获得及应用(简报)

在研究白血病导向治疗过程中,作者获得一组抗髓系单克隆抗体(McAb),分别命名为HIM又名(HI98),HIM_4、HIM_5、HI_115、HI_117和HI_43。 HIM_1、HIM_4和HIM_5是一组髓系特异性McAb,仅与粒、单细胞系(HL_60、K_562、U_937和KG_1)反应,可与80％外周血和50％骨髓中的粒和单核细胞反应;但不与淋巴细胞系、外周血淋巴细胞、红细胞和血小板反应。三种McAb与骨髓不同分化阶段的髓系细胞的反应模式不同,其相应抗原在急