肺癌患者IFN-γ和TNF-α免疫因子检测及其临床意义

目的:探讨肺癌患者干扰素-γ(IFN-γ)和肿瘤坏死因子-α(TNF-α)检测的临床意义。方法:选择我院2009-02/2010-04收治的肺癌患者84例作为实验组,77例健康患者作为对照组,分别静脉采血后,采用双抗体夹心ELISA法检测并分析IFN-γ和TNF-α的生物活性,并对两组患者以及实验组患者化疗后半年内IFN-γ和TNF-α的水平进行比较研究。结果:与对照组正常人群比较,实验组IFN-γ水平明显降低,而TNF-α水平明显提高,差异均具有统计学意义(P0.05)。与此同时,化疗后半年内,与未复发组相比,复发组IFN-γ水平明显提高,而TNF-α水平明显降低,差异均具有统计学意义(P0.05)。结论:更加深入地探讨肺癌患者的免疫损伤机制将有助于更好地指导治疗,并且具有重要的临床意义。     

肺减容术治疗重度肺气肿患者临床分析

Objective To study effectiveness and safety of lung volume reduction surgery(LVRS) in treatment for severe chronic emphysema(chronic obstructive pulmonary disease).Methods Clinical data of 24 patients of severe chronic emphysema undergone with LVRS during January 2004 to June 2007 were analyzed retrospectively.LVRS was performed for the patients after respiratory tract preparation based on their pulmonary function,results of blood gas analysis,cardiac function,as well as physical activity capacity.and surgical incision Was selected based on"target"location of emphysema with chest computerized tomography and isotope lung perfusion scanning,22 cases with standard unilateral LVRS via outer post-lateral incision and two with bilateral LVRS via mid-sternal incison.A linear device for cutting and stitching was used in surgical operation to excise the lung tissues of severe emphysema with strips of bovine pericardium to prevent air leakage.Results All the patients were followed-up for 19 months in average and complications occurred in seven of them after operation,including four with leakage of the alveoli.two with cardiac arrhythmia and one with pneumonia,and no death was observed.Pulmonary function and symptoms of dyspnea improved obviously in all the patients after operation,and they all could care for themselves,in general,with scales of dyspnea increased to grade Ⅰ in one case,to grade Ⅱ in 10 cases and to grade Ⅲ in three cases.Conclusions LVRS can improve pulmonary function of selected patients with severe emphysema,to certain extent,and its safety will depend on strict selection of the patients and correct peri-operative care.