三磷酸腺苷生物荧光法检测肿瘤药敏的价值

目的探讨三磷酸腺苷生物荧光法(ATP-TCA)评估肿瘤药物敏感性和指导术后化疗的价值.方法以ATP-TCA法在体外分别检测了59例5种实体瘤细胞对6种化疗药物的耐药率和敏感率.结果5-FU、MMC、DDP等6种常用化疗药物的耐药率＞75%.胃肠肿瘤的化疗药物敏感性差异无显著意义,泰素、羟基喜树碱、丝裂霉素和吡柔比星对肝癌的敏感率分别为91.7%、60.0%、50.0%和42.8%;诺维本、博莱霉素对食管癌敏感率为85.7%、42.9%.结论ATP-TCA法用于检测肿瘤化疗药物敏感性较为可靠,可作为指导实体瘤术后序贯性化疗的药物筛选手段.     

动脉插管化疗合并放疗治疗晚期和巨块型宫颈癌

目的 评价动脉插管化疗加放疗治疗晚期及巨块型宫颈癌的疗效。方法 将68例巨块型宫颈癌及78例晚期宫颈癌随机分为2个组，各73例。A组采用腹壁下动脉或股动脉插管化疗（顺铂、氟脲嘧啶及丝裂霉素化疗3个周期）加放疗；B组为单纯放疗。2组放疗均为外照射加腔内照射。结果 A组的3年生存率（78．08％；P＜0．05）高，局部复发率（17．81％，P＜0．05）低，A、B2组远处转移率及直肠膀胱并发症发生率无显著性差异。A组中2种插管法的治疗效果无显著性差异。结论 动脉插管化疗合并放疗治疗晚期及巨块型宫颈癌，可提高生存率，降低局部复发率，但不能降低远处转移率。     

小鼠骨性关节炎的模型制备及评价

目的探讨骨性关节炎的小鼠动物模型制备及评价方法。方法将昆明小鼠随机分为两组：即正常组和模型组。模型组采取4℃冷水冷冻刺激小鼠膝关节制作骨性关节炎模型。在造模15d和30d时分别对小鼠膝关节肿胀度进行关节炎指数（AI）评定；并取小鼠膝关节软骨作HE染色；用双抗体夹心-ELISA法检测大鼠血清中肿瘤坏死因子-α（TNF-α）、透明质酸（HA）水平。结果与正常组小鼠相比，30d时模型组小鼠AI值高达3．8；HE染色显示模型组小鼠出现典型的骨性关节炎病变症状；模型组血清中TNF-α、透明质酸含量有显著升高。结论小鼠冷冻造模能为研究骨性关节炎的发病机制提供理想的实验动物模型。     

冰敷对痔术后疼痛的影响(附100例报告)

疼痛是肛肠疾病术后最常见的并发症[1],也是病人最畏忌的并发症,许多病人因此而放弃治疗.为有效地预防术后疼痛,减轻病人的痛苦,增加手术的顺应性,笔者据冷疗的原理和目的[2],设计了早期肛门模型冰块加压包扎预防痔疮术后并发症的临床研究,证实了此法对预防术后疼痛及促进伤口愈合有良好的效果.     

2002～2006年吉林地区5岁以下儿童死亡分析

为了更有效地降低我地区5岁以下儿童死亡率，为政府制定相关政策提供依据，现将2002—2006年吉林地区5岁以下儿童死亡情况做以下分析： 1资料来源与方法     

原发性肝癌化疗药物敏感性检测的临床价值

目的 探讨三磷酸腺苷生物荧光法(ATP-TCA)评估原发性肝癌药物敏感性和指导术后介入化疗的临床价值。方法 以ATP-TCA法在体外分别检测了19例原发性肝癌细胞对6种化疗药物的耐药率和敏感率。结果 5FU、DDP等常用化疗药物的耐药率在78％以上，泰素、羟基喜树碱和丝裂霉素对肝癌的敏感率分别为89．67％、64．39％和47．11％。结论 ATP-TCA法用于检测原发性肝癌化疗药物敏感性稳定可靠，可作为指导肝癌术后序贯性化疗的药物筛选手段。     

"U"形钢板固定治疗肱骨干骨折

目的：探讨“U”形钢板在肱骨干骨折治疗中的疗效。方法：对13例不同情况下的肱骨干骨折运用“U”形钢板进行开放复位内固定。结果：本组13例肩肘关节活动度均为优，4～13周骨折达临床愈合，有桡神经损伤者功能恢复良好，无钢板、螺钉折弯断裂及再骨折。结论：“U”形钢板的长度及外形较小，手术创伤小，结构简单，固定强度大，关节功能锻炼早，愈合时间短，是一种具有足够承载能力的理想肱骨接骨板。     

关节镜辅助治疗桡骨远端关节内骨折

Objective To investigate the role of arthroscopy in the treatment of intra-articular distal radius fractures. Methods Twelve cases of intra-articular distal radius fractures treated from 2004 to 2007 were reviewed. In these cases, open reduction and internal fixation were performed with the assistance of wrist arthroscopy to observe the alignment of the articular surface. CT scan was obtained postoperatively to evaluate joint alignment, radial height, volar tilting and radial inclination. Recovery of the wrist function was also followed. Results The average postoperative follow up period was 24 months. None of the 12 cases was found to have any "step" appearance of the articular surface of the wrist. X-ray measurement showed radial height averaged 12 mm (7 to 15 mm), volar tilting averaged 5° (1° to9°) and radial inclination averaged 20 °(14° to28°). Range of motion of the wrist joint achieved 33° of flexion on average ( 18° to 42°) and 38° of extension on average (21° to 42°). Six cases had mild pain during motion. According to Gartland / Werley' s criteria, the result was excellent in 5 eases and good in 7. Conclusion Arthroscope-assisted treatment of intra-articular distal radius fractures can avoid "step" appearance of the articular surface of the wrist, thus achieve maximal functional recovery of the wrist.     

关节镜辅助治疗桡骨远端关节内骨折

Objective To investigate the role of arthroscopy in the treatment of intra-articular distal radius fractures. Methods Twelve cases of intra-articular distal radius fractures treated from 2004 to 2007 were reviewed. In these cases, open reduction and internal fixation were performed with the assistance of wrist arthroscopy to observe the alignment of the articular surface. CT scan was obtained postoperatively to evaluate joint alignment, radial height, volar tilting and radial inclination. Recovery of the wrist function was also followed. Results The average postoperative follow up period was 24 months. None of the 12 cases was found to have any "step" appearance of the articular surface of the wrist. X-ray measurement showed radial height averaged 12 mm (7 to 15 mm), volar tilting averaged 5° (1° to9°) and radial inclination averaged 20 °(14° to28°). Range of motion of the wrist joint achieved 33° of flexion on average ( 18° to 42°) and 38° of extension on average (21° to 42°). Six cases had mild pain during motion. According to Gartland / Werley' s criteria, the result was excellent in 5 eases and good in 7. Conclusion Arthroscope-assisted treatment of intra-articular distal radius fractures can avoid "step" appearance of the articular surface of the wrist, thus achieve maximal functional recovery of the wrist.     

关节镜辅助治疗桡骨远端关节内骨折

Objective To investigate the role of arthroscopy in the treatment of intra-articular distal radius fractures. Methods Twelve cases of intra-articular distal radius fractures treated from 2004 to 2007 were reviewed. In these cases, open reduction and internal fixation were performed with the assistance of wrist arthroscopy to observe the alignment of the articular surface. CT scan was obtained postoperatively to evaluate joint alignment, radial height, volar tilting and radial inclination. Recovery of the wrist function was also followed. Results The average postoperative follow up period was 24 months. None of the 12 cases was found to have any "step" appearance of the articular surface of the wrist. X-ray measurement showed radial height averaged 12 mm (7 to 15 mm), volar tilting averaged 5° (1° to9°) and radial inclination averaged 20 °(14° to28°). Range of motion of the wrist joint achieved 33° of flexion on average ( 18° to 42°) and 38° of extension on average (21° to 42°). Six cases had mild pain during motion. According to Gartland / Werley' s criteria, the result was excellent in 5 eases and good in 7. Conclusion Arthroscope-assisted treatment of intra-articular distal radius fractures can avoid "step" appearance of the articular surface of the wrist, thus achieve maximal functional recovery of the wrist.