2型糖尿病患者载脂蛋白e4等位基因与颈动脉中内膜厚度的关系

目的：了解2型糖尿病（diabetes mellitus,DM)患者载脂蛋白E（apolipoprotein E,apoE)基因型与颈动脉中内膜厚度的关系。方法：选择255例无血管并发症的2型DM患者和107名健康个体，采用聚合酶链反应等位基因特异寡核苷酸探针杂交技术检测其apoE基因型。结果：2型DM组与对照组apoE基因型及等位频率差异无显著性（P＞0．05）；两组中e4/4、e4/3亚组总胆固醇、低密度脂蛋白胆固醇、脂蛋白（a)水平明显高于e3/2、e2/2亚组（P＜0．05）；两组中e4/4、e4/3亚组颈动脉中内膜厚度明显高于e3/2,e2/2亚组（P＜0．05）。不论在对照组还是在2型DM ，当调整总胆固醇、低密度脂蛋白胆固醇、甘油三酯、脂蛋白（a)、血糖、年龄、体重指数、吸烟等因素的影响后，协方差分析结果显示，颈动脉中内膜厚度在这两个基因型亚组喑差异有显著性（P＜0．05）。结论：不论在健康人还是在2型DM患者，e4等位基因与早期颈动脉粥样硬化关联。     

丹参注射液与异甘草酸镁抗肝纤维化的临床对比研究

Objective To observe the change of liver function and liver fibrosis indexes of the chronic hepatitis B patients that were treated by Danshen injection(DI) and magnesium isnglyeyrrhizinate(MI). Methods 80 chronic hepati-tis B patients based on the conventional treatment were randomly divided into D1 group(40 patients) and MI group(40 pa-tients). The two groups were used with DI and MI injection for 30 days respaetively and then,the levels of liver function and serum hepatic fibrosis(HA, LN, Ⅳ -C) were detected and compared before and after treatment. Results Treatment by DI and MI could both improve liver function significantly, the effect of Ml group was better than DI group(P < 0.05). Moreover, in improving serum hepatic fibrosis, the effect of DI group was better than MI group (P < 0.05). Conclusions The efficacy of the improvement to hepatic fibrosis DI is better than MI, while in improvement of liver function MI is superior to DI.     

丹参注射液与异甘草酸镁抗肝纤维化的临床对比研究

Objective To observe the change of liver function and liver fibrosis indexes of the chronic hepatitis B patients that were treated by Danshen injection(DI) and magnesium isnglyeyrrhizinate(MI). Methods 80 chronic hepati-tis B patients based on the conventional treatment were randomly divided into D1 group(40 patients) and MI group(40 pa-tients). The two groups were used with DI and MI injection for 30 days respaetively and then,the levels of liver function and serum hepatic fibrosis(HA, LN, Ⅳ -C) were detected and compared before and after treatment. Results Treatment by DI and MI could both improve liver function significantly, the effect of Ml group was better than DI group(P < 0.05). Moreover, in improving serum hepatic fibrosis, the effect of DI group was better than MI group (P < 0.05). Conclusions The efficacy of the improvement to hepatic fibrosis DI is better than MI, while in improvement of liver function MI is superior to DI.     

干燥综合征肝损害误诊为病毒性肝炎1例报告

患者女,40岁,因“反复乏力,纳差,尿黄25年,加重1月”于2006年5月20日入院。患者1981年曾患“急性黄疸性肝炎”住院治疗,治愈后出院,后曾反复数次因肝功能异常住院考虑为“病毒性肝炎”予保肝治疗。平时常感乏力,口眼干涩,纳少,厌油腻饮食,食后腹胀,遇疲劳有加重。入院前1月渐感     

贞芪扶正胶囊对慢性乙型肝炎细胞免疫功能的影响

目的:探索贞芪扶正胶囊对慢性乙型肝炎患者的细胞免疫功能的影响.方法:将60例患者分为两组,对照组采用基础护肝治疗,治疗组在基础治疗的基础上加服贞芪扶正胶囊,连续3个月.观察临床疗效、主要症状体征改善情况及肝功能和淋巴细胞比值的变化.结果:总有效率治疗组为96.6%,对照组为80.0%,治疗组优于对照组(P＜0.05),且治疗后治疗组患者肝功能各项指标的改善及CD4的比值升高明显优于对照组,两组比较,差异有统计学意义(P＜0.05).结论:贞芪扶正胶囊能提高慢性乙型肝炎患者的细胞免疫功能.     

姜黄素对肝纤维化大鼠肝组织中核转录因子-кB及细胞外信号调节激酶-1mRNA表达的影响

目的 探讨核转录因子-кB (NF-кB )及细胞外信号调节激酶(ERK) mRNA在CCl4致实验性肝纤维化大鼠肝组织中的表达及姜黄素(CUR)对它们的影响.方法 建立CCl4致大鼠实验性肝纤维化的模型,用免疫组织化学法比较正常组、模型组以及CUR组的α平滑肌肌动蛋白(α-SMA)的表达,用RT-PCR法比较各组肝组织NF-кB以及ERK-1 mRNA的表达.结果 NF-кB mRNA 及ERK-1mRNA的表达: 正常组分别为0.317±0.035和0.434±0.067,模型组分别为1.219±0.158和0.944±0.151,CUR组分别为0.912±0.274和0.736±0.293,CUR组与模型组比较,P值均＜0.05,差异有统计学意义.α-SMA的表达:CUR组为4.327±2.064,模型组为6.784±2.158,正常组为0.943±0.371,CUR组与模型组比较,P值均＜0.05 ,差异有统计学意义.结论 CUR可能通过抑制α-SMA的表达,减弱NF-кB诱导的肝星状细胞的活化以及抑制ERK-1的促肝星状细胞的增殖,从而起到抗大鼠肝纤维化的作用.