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慢性乙型肝炎患者肝组织炎性活动程度与α-干扰素疗效的关系 总被引:3,自引:0,他引:3
目的 :探讨慢性乙型肝炎 (ChronichepatitisB ,CHB)患者肝组织炎性活动程度与α 干扰素 (α IFN )疗效的关系。方法 :对 84例使用赛诺金 (αlb IFN )的CHB患者治疗前肝活检组织进行炎症分级及Ishak计分 ,并与α IFN治疗后及停药 1年后复发情况作一对比分析。结果 :随着肝组织炎症分级进展 ,α IFN的完全应答率明显上升( χ2 =11 63 ;P <0 0 1)。停药 1年后不同炎症分级患者的HBV感染复发率并无差异。 8例完全应答者α IFN治疗结束时 ,肝组织Ishak计分自 12 8± 3 0降至 8 1± 2 8(t =3 2 4;P <0 0 1)。结论 :CHB肝组织炎症分级与α IFN近期疗效密切相关。α IFN完全应答者肝组织学状况明显改善 相似文献
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Objective To observe the change of liver function and liver fibrosis indexes of the chronic hepatitis B patients that were treated by Danshen injection(DI) and magnesium isnglyeyrrhizinate(MI). Methods 80 chronic hepati-tis B patients based on the conventional treatment were randomly divided into D1 group(40 patients) and MI group(40 pa-tients). The two groups were used with DI and MI injection for 30 days respaetively and then,the levels of liver function and serum hepatic fibrosis(HA, LN, Ⅳ -C) were detected and compared before and after treatment. Results Treatment by DI and MI could both improve liver function significantly, the effect of Ml group was better than DI group(P < 0.05). Moreover, in improving serum hepatic fibrosis, the effect of DI group was better than MI group (P < 0.05). Conclusions The efficacy of the improvement to hepatic fibrosis DI is better than MI, while in improvement of liver function MI is superior to DI. 相似文献
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Objective To observe the change of liver function and liver fibrosis indexes of the chronic hepatitis B patients that were treated by Danshen injection(DI) and magnesium isnglyeyrrhizinate(MI). Methods 80 chronic hepati-tis B patients based on the conventional treatment were randomly divided into D1 group(40 patients) and MI group(40 pa-tients). The two groups were used with DI and MI injection for 30 days respaetively and then,the levels of liver function and serum hepatic fibrosis(HA, LN, Ⅳ -C) were detected and compared before and after treatment. Results Treatment by DI and MI could both improve liver function significantly, the effect of Ml group was better than DI group(P < 0.05). Moreover, in improving serum hepatic fibrosis, the effect of DI group was better than MI group (P < 0.05). Conclusions The efficacy of the improvement to hepatic fibrosis DI is better than MI, while in improvement of liver function MI is superior to DI. 相似文献
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目的 研究甲状腺激素对血浆脂蛋白 (a) [LP(a) ]浓度的影响。方法 采用ELISA法检测血浆LP(a)浓度 ,纵向观察 8例甲亢患者放射性13 1I治疗前后血浆LP(a)浓度的变化。我们测定下列 3种状态的LP(a)浓度 ,即治疗前甲亢状态 (H状态 )、丙基硫氧嘧啶治疗后的甲状腺功能呈基本正常状态 (E1状态 )和放射性13 1I治疗后甲状腺功能正常状态 (E2状态 )。结果 治疗前H状态血脂LP(a) ,TC ,HDL -C ,LDL -C ,apoA1和apoB浓度低于对照组 (P <0 .0 5 ) ;从H到E1,再到E2状态 ,LP(a)浓度逐渐升高 ,差异具有统计学意义 (P <0 .0 5~ 0 .0 1)。TC ,DL -C ,apoA1及apoB2亦有类似的变化 (P <0 .0 5~ 0 .0 1) ;治疗前后LP(a)的变化与FT3(r =- 0 .0 4 )和FT4 (r=- 0 .4 6 )的变化呈负相关 (P <0 .0 5 )。结论 甲状腺激素对LP(a)的代谢有调控作用。 相似文献
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目的 探讨核转录因子-кB (NF-кB )及细胞外信号调节激酶(ERK) mRNA在CCl4致实验性肝纤维化大鼠肝组织中的表达及姜黄素(CUR)对它们的影响.方法 建立CCl4致大鼠实验性肝纤维化的模型,用免疫组织化学法比较正常组、模型组以及CUR组的α平滑肌肌动蛋白(α-SMA)的表达,用RT-PCR法比较各组肝组织NF-кB以及ERK-1 mRNA的表达.结果 NF-кB mRNA 及ERK-1mRNA的表达: 正常组分别为0.317±0.035和0.434±0.067,模型组分别为1.219±0.158和0.944±0.151,CUR组分别为0.912±0.274和0.736±0.293,CUR组与模型组比较,P值均<0.05,差异有统计学意义.α-SMA的表达:CUR组为4.327±2.064,模型组为6.784±2.158,正常组为0.943±0.371,CUR组与模型组比较,P值均<0.05 ,差异有统计学意义.结论 CUR可能通过抑制α-SMA的表达,减弱NF-кB诱导的肝星状细胞的活化以及抑制ERK-1的促肝星状细胞的增殖,从而起到抗大鼠肝纤维化的作用. 相似文献
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姜黄素对肝纤维化大鼠肝组织中NF-κB及ERK-1 mRNA表达的影响 总被引:2,自引:0,他引:2
目的 探讨核转录因子-κB(nuclear factor kappa B,NF-κB)及细胞外信号调节激酶(extracegular signal-reglulated kinase,ERK)mRNA在CCl4致实验性肝纤维化大鼠肝组织中的表达及姜黄素(curcumin,CUR)对它们的影响.方法 建立CCl4致大鼠实验性肝纤维化的模型,用免疫组化法比较正常组、模型组及CUR组的α平滑肌肌动蛋白(α-SMA)的表达,用RT-PCR法比较各组肝组织NF-κB及ERK-1 mRNA的表达.结果 模型组中,ERK-1及NF-κB mRNA的表达均增高,而CUR组α平滑肌肌动蛋白则较模型组低,NF-κB及ERK-1 mRNA的表达也降低.结论 CUR可能通过抑制α-SMA的表达,减弱NF-κB诱导的肝星状细胞的活化及抑制ERK-1促肝星状细胞的增殖,从而产生抗四氯化碳诱导的大鼠肝纤维化的作用. 相似文献
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目的:探讨拉米夫定(LAM)联合阿德福韦酯(AVD)治疗乙型肝炎肝硬化失代偿期的疗效、安全性。方法:选择2006年6月~2008年6月门诊和住院乙型肝炎肝硬化失代偿期患者93例,随机分为3组。A组单用LAM(100mg·d-1);B组采用ADV(10mg·d-1);C组采用ADV(10mg·d-1)、LAM(100mg·d-1)联合治疗;3组均治疗52周。结果:治疗52周时3组患者间ALT水平、HBeAg阳性患者血清转换率比较,差异均无统计学意义(P>0.05);C组患者HBVDNA水平达到检测水平以下的百分率与B组患者比较,有显著性差异(P<0.05);3组间肝功能Child-Pugh评分比较差异无统计学意义(P>0.05)。3组患者的基因型耐药率分别为21.9%(7/32)、0、0。结论:乙型肝炎肝硬化失代偿期采用LAM联合ADV治疗更安全有效。 相似文献
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Objective To observe the change of liver function and liver fibrosis indexes of the chronic hepatitis B patients that were treated by Danshen injection(DI) and magnesium isnglyeyrrhizinate(MI). Methods 80 chronic hepati-tis B patients based on the conventional treatment were randomly divided into D1 group(40 patients) and MI group(40 pa-tients). The two groups were used with DI and MI injection for 30 days respaetively and then,the levels of liver function and serum hepatic fibrosis(HA, LN, Ⅳ -C) were detected and compared before and after treatment. Results Treatment by DI and MI could both improve liver function significantly, the effect of Ml group was better than DI group(P < 0.05). Moreover, in improving serum hepatic fibrosis, the effect of DI group was better than MI group (P < 0.05). Conclusions The efficacy of the improvement to hepatic fibrosis DI is better than MI, while in improvement of liver function MI is superior to DI. 相似文献