Observation on clinical effects of acupoint thread-embedding method for non-alcoholic fatty liver disease

Objective

To observe the clinical effects of acupoint thread-embedding method for non-alcoholic fatty liver disease (NAFLD) in pattern of liver qi stagnation and spleen deficiency.

Methods

A total of 180 cases in conformity with the diagnostic criteria of NAFLD in pattern of liver qi stagnation and spleen deficiency were randomly divided into a treatment group and a control group, 90 cases in each group, and finally 88 cases in the treatment group and 90 cases in the control group were recruited for statistics. The treatment group was managed by acupoint thread-embedding method, and the control group was treated by oral administration of Polyene Phosphatidylcholine capsules. Both groups were treated for 6 months. Before and after the treatment, liver enzymology, blood fat test, abdominal B ultrasonic examination, and assessment of clinical effects were respectively processed.

Results

After treatment, alanine transaminase (ALT), aspartate transaminase (AST), total cholesterol (TC), and triglyceride (TG) decreased in the treatment group, and were significantly different from those in the control group after treatment (all P<0.05). There was no statistically significant inter-group difference in the degree of fatty liver (by B ultrasound examination) before treatment (P>0.05). After treatment, the improvement degree of fatty liver in the treatment group was more significant than that in the control group (P<0.05). The total effective rates were 89.8% in the treatment group and 76.7% in the control group, with a statistically significant difference between the two groups (P<0.05).

Conclusion

The acupoint thread-embedding method can reduce the levels of ALT, AST, TC and TG in NAFLD patients, and can improve the pathologic degree of fatty liver and its clinical effects are remarkably better than that of oral medications.

     

龙血竭紫草软膏在皮肤软组织扩张术后的运用研究——附38例临床资料

目的:观察皮肤软组织扩张术后配合龙血竭紫草软膏治疗的临床疗效。方法:皮肤软组织扩张器二期手术后患者76例,随机分为治疗组和对照组,每组38例。术后治疗组给予龙血竭紫草软膏外用,对照组给予肝素钠软膏外用。术后7、14d,分别从扩张皮瓣的颜色、张力、皮温和伤口愈合情况等几方面来综合判断并比较2组的治疗效果。结果:术后7d,治疗组临床优秀率50.0%,对照组优秀率42.1%,组间比较无统计学差异(P0.05);术后14d,治疗组临床优秀率68.4%,对照组优秀率42.1%,治疗组明显优于对照组(P0.05)。结论:龙血竭紫草软膏能较好地改善扩张后皮瓣血运,提高扩张术后皮瓣的存活率,有临床应用价值。     

维思通治疗不同年龄的女性精神分裂症患者疗效与不良反应对照研究

目的：评价维思通对不同年龄的女性精神分裂症患者的疗效和安全性。方法：68例女性精神分裂症患者按年龄分为3组，使用维思通治疗4周以上，以简明精神病评定量表（BPRS）评定疗效，并评定每位患者在整个治疗过程中出现的不良反应，对疗效及不良反应进行比较。结果：维思通治疗女性精神分裂症患者有效率达78．6％～81．0％，BPRS减分率34．4％～43．9％，且不良反应发生率较低，在45～65岁的高年龄组，应用维思通的疗效似乎更好，且月经失调发生率更低。结论：维思通是一种安全有效的抗精神病药物，尤其适合年龄较大的女性精神分裂症患者。     

急性冠状动脉综合征患者血清纤维连接蛋白的变化

目的观察急性冠状动脉综合征不同类型患者血清纤维连接蛋白(Fn)水平的变化,探讨其在急性冠状动脉综合征发病中的作用和临床意义。方法急性冠状动脉综合征患者分为急性心肌梗死组50例、不稳定型心绞痛组17例,另设健康对照组13例,采用双抗体夹心固相酶联免疫吸附法测定血清Fn的水平。结果急性冠状动脉综合征组血清Fn的水平显著低于健康对照组[(233.38±119.15)μg/ml,(296.46±65.44)μg/ml,P<0.05];急性心肌梗死组与不稳定型心绞痛组血清Fn的水平差异无统计学意义。血清Fn的水平在不同的冠状动脉病变程度之间的差异无统计学意义[单支血管病变(226.83±112.35)μg/ml,双支病变(231.15±128.06)μg/ml及三支病变(277.32±139.61)μg/ml,F=0.825,P=0.445]。结论急性冠状动脉综合征患者血清Fn的水平显著低于健康对照组,与冠状动脉病变的程度无相关性。     

大鼠孕期甲状腺功能及自身抗体变化的研究

目的 观察Wistar大鼠正常孕期不同阶段甲状腺功能及自身抗体的变化规律.方法 SPF/VAF级健康成年雌性Wistar大鼠64只,按随机数字法分为对照组、孕早期组、孕中期组、孕晚期组,每组各16只.后3组雌鼠与雄鼠合笼成功交配后,分别于孕7d、14d、20 d对雌鼠采用代谢笼收集尿液、股动脉放血处死,对照组与孕中期组同批处理.采用过硫酸铵消化-砷铈催化分光光度法测定尿碘浓度,化学发光免疫分析法测定总T3、总T4、游离T3、游离T4、促甲状腺激素(TSH)水平,放射免疫分析法测定甲状腺球蛋白(Tg)、甲状腺球蛋白抗体(TgAb)、甲状腺过氧化物酶抗体(TPOAb)水平.结果 4组间尿碘水平差异无统计学意义(x2=2.798,P ＞0.05).孕早期组总T3水平高于对照组,而孕中期组、孕晚期组总T3水平低于孕早期组(F =3.775,P＜0.05).与对照组相比,孕早期组总T4水平升高,而孕中期组及孕晚期组水平依次降低(P＜0.05).游离T3、游离T4水平有随孕期延长而逐渐下降的趋势,且孕中期组、孕晚期组与其余两组相比差异有统计学意义(F =34.718,41.715,P均＜0.01).游离T3/游离T4比值随孕期延长逐渐升高.与对照组相比,孕早期组、孕中期组、孕晚期组TSH水平依次升高,且孕中期组、孕晚期组差异有统计学意义(x2=16.101,P＜0.01).Tg、TgAb、TPOAb水平在各组间差异均无统计学意义(P均＞0.05).结论 Wistar大鼠甲状腺功能在孕期不同阶段存在动态变化,与人体孕期变化规律基本一致,但大鼠孕期未显示甲状腺自身抗体的明显改变,提示大鼠有可能用于人类孕期实验研究.     

小儿腰穿束缚衣的临床应用效果观察

目的观察小儿腰穿束缚衣的制作与临床应用效果。方法选择行腰穿或硬膜外麻醉的患儿105例,随机分成对照组（不用小儿腰穿束缚衣）和观察组（应用小儿腰穿束缚衣）,比较两组体位固定成功率、腰穿一次成功率、家长和医护满意度等。结果观察组体位固定成功率98．53％,腰穿一次成功率94．12％,家长满意度91．18％,医护满意度97．06％;对照组分别为43．24％、37．84％、24．32％、27．03％。两组比较均有统计学差异（P均〈0．05）。结论小儿腰穿束缚衣取材方便,容易穿脱,临床应用效果良好。     

肛瘘等病术后外用大黄粉止血77例

我科从1982年4月～1983年11月,采用大黄粉外用对肛瘘手术、外痔切除及直结肠活体检查术后出血77例进行治疗,止血效果满意,现报告如下。药物配制大黄焙干,研碎成末,过100～120目筛,装瓶备用。适应症肛门瘘管、肛裂、外痔切除术、直结肠活体检查术,以及上述疾病术后出血和内痔出血者。