桂枝肌瘤丸联合热熨疗法治疗慢性盆腔炎性包块120例疗效观察

<正>盆腔炎性疾病(pelvic inflammatory disease,PID)是生育期妇女常见病、多发病,发病率近年逐渐上升,是女性内生殖器官(包括子宫、输卵管、卵巢)及其周围结缔组织和盆腔腹膜的慢性炎症。其中大多数患者有盆腔包块,大小不一,如治疗不彻底,可导致慢性盆腔痛及病情反复发作、不孕症及异位妊娠等。目前,西医对慢性盆腔炎性包块多采用抗生素治疗,疗效不彻底,且副作用较多。2011-06—2013-06,我们应用桂枝肌瘤     

HPLC-ELSD法同时测定复方丹参缓释片中丹参酮ⅡA和人参皂苷Rb1含量

目的建立同时测定复方丹参缓释片中丹参酮ⅡA和人参皂苷Rb1含量的方法。方法采用高效液相色谱-蒸发光散射检测法。色谱柱为Agilent C18(250mm×4.6mm,5μm),乙腈为流动相A,0.02%磷酸溶液为流动相B,梯度洗脱(0~5min,20%~25%流动相A;5~30min,25%~45%流动相A),流速:1.0mL.min-1,蒸发光散射检测器,氮气流量1.6L.min-1,漂移管温度70℃。结果丹参酮ⅡA和人参皂苷Rb1分别在7.295~116.7μg.mL-1和4.063~65.00μg.mL-1的范围内呈良好线性关系,平均回收率分别为96.70%和98.92%,RSD分别为1.46%和0.93%。结论该方法操作简单、快速、准确,重复性好,可用于复方丹参缓释片的质量控制。     

门诊和住院患儿药疹354例临床分析

药疹是临床上常见的药物反应 ,重症可危及生命 ,目前临床用药较繁杂 ,发病率有逐年增高趋势。为了总结药疹的临床特征 ,降低发病率 ,我们对 4年来我院药疹患儿做一回顾性总结 ,现报告如下。1　临床资料1 1　病例特点　全部病例来源于 1998年 3月至 2 0 0 2年 3月我院儿科和皮肤科门诊和住院患儿 ,年龄为 18d至 14岁 ,其中新生儿 2 5例 (7 1% ) ,～ 3岁 16 3例 (46 0 % ) ,～ 7岁 97例 (2 7 4 % ) ,～ 14岁 5 9例 (16 7% )。男 198例 ,女15 6例。原发病为感染性疾病 30 3例 (85 6 % ) ,其中包括上呼吸道感染 12 4例 ,急性支气管炎 6 8例 ,…     

岩白菜驯化栽培研究

岩白菜Bergenia purpurascens(Hook. f. et Thoms)Engl.属虎耳草科岩白菜属(Bergenia Moench)植物，是提取岩白菜素的主要野生药用原料。据调查和资料显示，全世界岩白菜有10种，中国有7种。分布于云南的主要有岩白菜、舌岩白菜。近期发现的还有天全岩白菜和淡红岩白菜(新变种)。     

LASIK术后屈光回退者二次手术探讨

目的探讨LASIK术后屈光回退者行二次手术的最佳方案。方法，对在我院眼科准分子激光治疗中心行LASIK应用0．95mm光斑高速飞点切削术后产生屈光回退者24例（36眼）各时间段散瞳后的屈光状态、角膜地形图进行分析，得出二次手术的最佳方案。结果术前屈光度在-1．00～-6．00D者二次手术时间为术后6个月，屈光度在-6．25～-12．00D者二次手术应适当推迟，最好为术后12个月分。结论。LASIK术后屈光回退者行二次手术要根据患者第一次手术前的预矫屈光度；术后角膜地形图情况确定最佳手术方案。     

桂枝肌瘤丸配合热熨对盆腔炎患者血液流变学的影响

目的观察自制药桂枝肌瘤丸联合热熨疗法对慢性盆腔炎患者血液流变学的影响。方法100例慢性盆腔炎患者分为2组,治疗组口服桂枝肌瘤丸联合热熨治疗,对照组静脉滴注抗生素,3个疗程后观察疗效。结果治疗组与治疗组在治疗后全血低切、全血高切、血浆粘度、红细胞聚集指数、纤维蛋白原都呈下降趋势,但治疗组下降的幅度明显大于对照组,两组治疗前后比较,差异具有统计学意义（P〈0．05）。结论桂枝肌瘤丸配合热熨疗法在改善盆腔炎患者血液流变学方面作用显著。     

头孢克肟口腔崩解片质量标准研究

目的研究头孢克肟口腔崩解片的质量标准。方法采用桨法及紫外-可见分光光度法测定其溶出度,利用自制崩解装置测定其体外崩解时限;采用高效液相色谱法测定其含量。结果头孢克肟口腔崩解片的平均崩解时限为38 s,片重差异符合规定;溶出度测定：头孢克肟的pH6.5磷酸盐缓冲液在288 nm波长处有最大吸收,且在3.0～22.5μg.mL^-1浓度范围内与吸光度（A）呈良好的线性关系,回归方程为A=0.0372ρ-0.0056,r=0.999 5;含量测定：头孢克肟在20～400μg.mL-1浓度范围内与色谱峰面积（A）呈良好的线性关系,回归方程为A=20.6ρ-76.3,r=0.999 2,平均回收率为100.25%,RSD值为0.70%。结论本方法专属性强、准确、简便、重现性好,可以有效控制头孢克肟口腔崩解片的质量。     

金平19株伤寒菌噬菌体型和在民族间分布

1987年金平县连续发生3起伤寒暴发,共发病378例,死亡17例,病死率4.49％。发病年龄最小1岁,最大79岁。     

Studies on mechanism of treatment of granulocyte colony-stimulating factor,recombinant human interleukin-11 and recombinant human interleukin-2 on hematopoietic injuries induced by 4.5 Gy γ-rays irradiation in beagles

Objective To investigate the mechanism of treatment of granulocyte colony-stimulating factor(rhG-CSF),recombinant human interleukin-11(rhIL-11)and recombinant human interleukin-2 (rhIL-2)on hematopoietic injuries induced by 4.5 Gy60 Coγ-ray irradiation in beagles,and to provide experimental evidence for the clinical treatment of extremely severe myeloid acute radiation sickness (ARS).Methods Sixteen beagle dogs were given 4.5 Gy60 Co γ-ray total body irradiation(TBI),then randomly assigned into irradiation control group,supportive care group or cytokines+supportive care (abbreviated as cytokines)group.In addition to supportive care,rhG-CSF,rhlL-11 and rhIL-2 were administered subcutaneously to treat dogs in cytokines group.The percentage of CD34+cells,cell cycle and apoptosis of nucleated cells in peripheral blood were examined by Flow cytometry.Results After 4.5 Gy 60 Co γ-ray irradiation,the CD34+cells in peripheral blood declined obviously(61.3%and 52.1% of baseline for irradiation control and supportive care group separately).The cell proportion of nucleated cells in Go/G1 phase was increased notably(99.27% and 99.49% respectively).The rate of apoptosis(26.93% and 21.29% separately)and necrosis(3.27% and 4.14%,respectively)of nucleated cells were elevated significantly when compared with values before irradiation(P<0.05) 1 d post irradiation.When beagles were treated with cytokines and supportive care,the CD34+cells in peripheral blood were markedly increased(135.6% of baseline).The effect of G0/G1 phase blockage of nucleated cells became more serious(99.71%).The rate of apoptosis(5.66%)and necrosis(1.60%)of nucleated cells were significantly lower than that of irradiation control and supportive care groups 1 d after exposure.Conclusions Cytokines maybe mobilize CD34+cells in bone marrow to peripheral blood,indce cell cycle block at G0/G1 phase and reduce apoptosis,and eventually cure hematopoieticinjuries induced by irradiation.