2010'临床泌尿外科杂志国际学术会议在兰州隆重召开

<正>为推动泌尿外科继续教育事业的发展,提高泌尿外科技术人员创造能力和专业技术水平,由《临床泌尿外科杂志》编委会主办,甘肃省泌尿外科专业委员会协办,兰州大学第二医院承办的"2010'临床泌尿外科杂志国际学术会议暨泌尿系肿瘤学与临床研讨会"于8月6～9日在金城兰州隆重开幕。     

当归精油对脓毒症小鼠的治疗作用

目的:观察当归精油对脓毒症小鼠的治疗作用。方法:i.v.给予细菌脂多糖复制小鼠脓毒症模型,i.v.给予不同剂量的当归精油,记录小鼠7 d生存率,ELISA法测定血清中细胞因子TNF-α和IL-6含量。结果:在100 mg/kg剂量下,当归精油可提高内毒素(25 mg/kg)攻击小鼠的生存率(P<0.01);在内毒素(25 mg/kg)攻击前、后2 h内给药能提高小鼠生存率,提前1 h预防性给药生存率最高(P<0.01);25～100 mg/kg当归精油能对抗0.125 mg/kg内毒素引起的TNF-α、IL-6水平增高,降低小鼠血清TNF-α、IL-6水平(P<0.05或P<0.01)。结论:当归精油能拮抗内毒素引起的炎症反应,对脓毒症有一定的治疗作用。     

FK506抑制脊髓挫伤后诱导型一氧化氮合酶表达的实验研究

目的观察大鼠脊髓挫伤后早期应用FK506对诱导型一氧化氮合酶(iNOS)表达的抑制作用。方法45只成年雄性大鼠随机分为假手术组、对照组和治疗组。治疗组在脊髓挫伤后5 min一次性经尾静脉注射FK506(0.3mg/kg),其余两组以相同方法给予0.9%生理盐水。伤后3,7,14,21 d采用BBB评分法进行后肢运动功能评价,应用逆转录聚合酶链反应(RT-PCR)和免疫组织化学染色检测iNOS的mRNA和蛋白质的表达,同时行脊髓组织尼氏染色病理学观察。结果治疗组病理学观察和行为学评分明显优于对照组(P<0.05,P<0.01);iNOS的mRNA和蛋白质的表达均于伤后7 d达高峰,两者表达在治疗组明显低于对照组(P<0.05,P<0.01)。结论FK506能抑制大鼠脊髓挫伤后iNOS表达,减轻继发性损害,从而改善脊髓损伤后的功能恢复。     

北京市农村居民卫生服务需求和利用状况分析

运用多阶段抽样的方法调查北京地区192户农村居民，了解了农民卫生服务需求和利用状况，分析了北京农村卫生服务利用中存在的问题。结果表明目前北京农村社区卫生服务体系建设已经初见成效，农民满意度比较高，公共卫生意识日益增强。北京农村卫生事业中存在的主要问题是预防保健服务供给量不足、医疗费用昂贵和医疗保障水平不高，针对调研发现的问题提出了解决策略。     

化学合成的生物降解聚合物在医药领域的应用进展

介绍了目前生物降解聚合物特别是PLA、PLGA在整形外科固定件及缝线上的应用,系统综述其作为缓控释注射剂,如微球,嵌段共聚物胶束,凝胶注射剂等和埋植剂骨架材料的应用进展,并简要介绍了聚酸酐这类生物降解聚合物的特点及应用前景。     

地黄饮子治疗高血压脑出血术后临床观察

目的:观察中西医结合治疗对高血压脑出血术后运动、语言功能的影响.方法:95例患者随机分为治疗组53例,予以地黄饮子为主方的的中西医结合治疗,对照组42例,予常规治疗.治疗2个疗程后进行疗效评价.结果:治疗组语言、运动评分均优于对照组,P＜0.05.结论:运用以地黄饮子为主方的中西医结合治疗对脑出血术后运动、语言功能恢复疗效显著.     

Effect of FK506 on Expression of Hepatocyte Growth Factor in Murine Spinal Cord Following Peripheral Nerve Injury

This study is to investigate the effect of FK506 on expression of hepatocyte growth factor （HGF） in rats＇ spinal cord following peripheral nerve injury and to elucidate the mechanisms for neuroprotective property of FK506. Fifty male rats were randomly divided into normal group, injury group and treatment group. Models of peripheral nerve injury were established by bilateral transection of sciatic nerve 0.5 cm distal to piriform muscle. Then the treatment group received subcutaneous injection of FK506 （1 mg/kg） at the back of neck, while the injury group was given 0.9% saline. The L4-6 spinal cords were harvested at various time points after the surgery. Western blotting and immunofluorescent staining were used to detect the level and position of HGF in spinal cord. Immunofluorescent staining showed that HGF-positive neurons were located in anterior horn, intermediate zone and posterior horn of gray matter in normal spinal cord. Western blotting revealed that there was no significant difference in the expressions of HGF between the injury group and the normal group, while the expression of HGF was significantly higher in the treatment group than in the injury group 7 and 14 days after surgery. It is suggested that peripheral nerve injury does not result in up-regulation of the expression of HGF in spinal cord, while FK506 may induce high expression of endogenous HGF after injury thereby protecting neurons and promoting axonal outgrowth.     

分娩期产痛与心理护理

目的:探讨减轻产妇分娩过程中产痛的方法,使产妇顺利分娩.方法:对产妇进行健康教育,加强心理护理.结果:正常产率上升,产痛减轻.结论:对产妇加强心理护理可使产痛减轻,产妇顺利分娩.     

生物降解聚合物在新型给药系统和医疗器械中的应用进展

本文概要介绍了目前生物降解聚合物的类型,重点是聚酯类在缝线及整形外科固定件上的应用,系统综述如以微球,嵌段共聚物胶束为载体的缓控释注射剂,温度敏感的相变凝胶注射剂等以及埋植剂骨架材料的应用进展。