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31.
妊娠早期左旋甲状腺素治疗亚临床甲减母鼠可改善仔鼠神经智力发育 总被引:1,自引:1,他引:0
目的 探讨妊娠早期左旋甲状腺素治疗母鼠亚临床甲减对仔鼠大脑发育的影响.方法 90只Wistar雌鼠随机分成假手术对照组(C)、甲减组(CH)、亚临床甲减组(SCH)、亚临床甲减治疗Ⅰ组(妊娠第10天开始治疗,E10)、亚临床甲减治疗Ⅱ组(E13)、亚临床甲减治疗Ⅲ组(E17),检测仔鼠体重、甲状腺功能,行水迷宫实验、Nissl染色和免疫组化染色.结果 CH组及SCH组仔鼠体重低于C组仔鼠(P<0.05),但E10、E13及E17治疗组体重均未受影响(P>0.05).各组仔鼠甲状腺功能无区别(P>0.05).CH、SCH及E17治疗组仔鼠逃避潜伏期比C组仔鼠延长(P<0.05),海马CA1区及皮质神经元排列紊乱,海马锥体层增厚,辐射层较薄,神经细胞迁移位置异常,E10及E13治疗组与C组仔鼠无区别.结论孕鼠SCH能够对后代学习记忆能力造成损害,影响细胞构筑及大脑细胞迁移,在E13之前应用左旋甲状腺素治疗可有效改善后代学习记忆能力、细胞构筑及细胞迁移. 相似文献
32.
史晓光 崇巍 单忠艳 滕晓春 滕笛 关海霞 李玉姝 金迎 于晓会 范晨玲 杨帆 戴红 于扬 李佳 陈彦彦 赵冬 胡凤楠 毛金媛 谷晓岚 杨榕 佟雅洁 王微波 高天舒 李晨阳 滕卫平 《中华内分泌代谢杂志》2008,25(1):260-263
Objective To clarify the effect of iodine intake on serum thyroglobulin (Tg). Methods A 5-year prospective study was conducted in the 3 different iodine intake areas in China [Panshan (miht deficiency) ,Zhangwu (more than adequate) and Huanghua (excess)]. A total of 3 099 people with normal serum levels of Tg in 1999 were followed and 2 448 of these participants were feasible to be observed in 2004 and included in the present study. The serum levels of Tg, thyraglobulin antibody(TgAb), thyroid peroxidase antibody(TPOAb) and TSH, thyroid volume, family and personal histories of thyroid diseases were measured and inquried. The general linear model (GLM) was used to explore the determinants of Tg. Results Among the study population at baseline, serum Tg were significantly different in three areas [7.5 (4.4-13. 1) μg/L at Panshan, 6.8 (3.6-11.2)μg/L at Huanghua, 5.9 (3.2-10.7) μg/L at Zhangwu, P<0.01]. They were associated with age, sex and the rate of positive TgAb, abnormal thyroid volume, abnormal TSH and positive personal history of thyroid diseases, in order to control the effects of confounding factors, the data from 1856 subjects with thyroid-related indexes all in normal range and without personal history of thyroid diseases were analyzed to clarify the effect of iodine intake on Tg. The serum Tg among three areas were significantly different in both 1999 and 2004, they were all increased in 5 years with significant augment (△ Tg) among the three areas[3.1 (-0.2-8.0) μg/L at Panshan, 3.5 (0.5-9.0)μg/L at Huanghua vs 2. 5(0.3-6.1) μg/L at Zhangwu,P<0.01]. The GLM analysis revealed that age, Tg and TSH levels at baseline were the determinants of △Tg in addition to iodine intake. Conclusion Iodine intake is a dominant determinant of serum Tg. Age and TSH should also be considered while indicating iodine intake by serum Tg. 相似文献
33.
目的 探讨电感耦合等离子体质谱法?(ICP-MS)?和砷铈催化分光光度法?(S-K法)?检测尿碘浓度?(UIC)?的一致性.方法 收集1856例成人空腹尿液样本,通过标准化ICP-MS和S-K法同时检测UIC,同时根据S-K法测定的UIC值分为3组,进行分层分析.采用Spearman等级相关对ICP-MS与S-K法测定... 相似文献
34.
史晓光 崇巍 单忠艳 滕晓春 滕笛 关海霞 李玉姝 金迎 于晓会 范晨玲 杨帆 戴红 于扬 李佳 陈彦彦 赵冬 胡凤楠 毛金媛 谷晓岚 杨榕 佟雅洁 王微波 高天舒 李晨阳 滕卫平 《中华内分泌代谢杂志》2009,25(1):260-263
Objective To clarify the effect of iodine intake on serum thyroglobulin (Tg). Methods A 5-year prospective study was conducted in the 3 different iodine intake areas in China [Panshan (miht deficiency) ,Zhangwu (more than adequate) and Huanghua (excess)]. A total of 3 099 people with normal serum levels of Tg in 1999 were followed and 2 448 of these participants were feasible to be observed in 2004 and included in the present study. The serum levels of Tg, thyraglobulin antibody(TgAb), thyroid peroxidase antibody(TPOAb) and TSH, thyroid volume, family and personal histories of thyroid diseases were measured and inquried. The general linear model (GLM) was used to explore the determinants of Tg. Results Among the study population at baseline, serum Tg were significantly different in three areas [7.5 (4.4-13. 1) μg/L at Panshan, 6.8 (3.6-11.2)μg/L at Huanghua, 5.9 (3.2-10.7) μg/L at Zhangwu, P<0.01]. They were associated with age, sex and the rate of positive TgAb, abnormal thyroid volume, abnormal TSH and positive personal history of thyroid diseases, in order to control the effects of confounding factors, the data from 1856 subjects with thyroid-related indexes all in normal range and without personal history of thyroid diseases were analyzed to clarify the effect of iodine intake on Tg. The serum Tg among three areas were significantly different in both 1999 and 2004, they were all increased in 5 years with significant augment (△ Tg) among the three areas[3.1 (-0.2-8.0) μg/L at Panshan, 3.5 (0.5-9.0)μg/L at Huanghua vs 2. 5(0.3-6.1) μg/L at Zhangwu,P<0.01]. The GLM analysis revealed that age, Tg and TSH levels at baseline were the determinants of △Tg in addition to iodine intake. Conclusion Iodine intake is a dominant determinant of serum Tg. Age and TSH should also be considered while indicating iodine intake by serum Tg. 相似文献
35.
于晓会 范晨玲 单忠艳 滕晓春 滕笛 关海霞 李玉姝 崇巍 杨帆 戴红 何力 高庆军 于扬 李佳 陈彦彦 赵冬 毛金媛 谷晓岚 杨榕 姜雅秋 李晨阳 滕卫平 《中华内分泌代谢杂志》2005,25(1):255-259
目的 研究不同碘摄入量人群非毒性甲状腺肿(甲肿)和非毒性甲状腺结节的流行病学特点及影响其发生、发展和转归的因素.方法 2004年对盘山(长期轻度碘缺乏)、彰武(碘缺乏基础上补碘至碘超足量)和黄骅(长期碘过量)社区于1999年参加本课题组流行病学研究并进行甲状腺B超检查的人群(3 385人)进行甲状腺疾病的随访调查.结果 (1)盘山、彰武和黄骅社区弥漫型甲肿的累积发病率分别为7.1%、4.4%和6.9%,盘山和黄骅均显著高于彰武(均P<0.01);结节型甲肿的累积发病率分别为5,0%、2.4%和0.8%,盘山的发病率最高(P<0.01).(2)三社区甲状腺单发结节的累积发病率分别为4.0%、5.7%和5.6%,多发结节的累积发病率分别为0.4%、1.2%和1.0%.(3)基础碘缺乏、碘过量、甲状腺自身抗体(thyroid autoantibody,TAA)阳性是甲肿发生的独立危险因素.(4)彰武初访时TAA阳性人群非毒性甲肿的发生率显著高于TAA阴性人群(P<0.01),盘山和黄骅无显著差异.(5)三社区非毒性弥漫型甲肿维持人群和黄骅非毒性结节型甲肿维持人群随访前后TAA阳性率均高于同社区正常人群(P<0.05).结论 碘缺乏和碘过量均有可能使甲肿的发病率增加.碘缺乏社区结节型甲肿高发,弥漫型甲肿是碘过量社区甲肿发牛的主要形式.甲状腺自身免疫与甲肿的发生和维持相关,这种相关性在历史上为碘缺乏而后过度补碘的社区更明显. 相似文献
36.
史晓光 崇巍 单忠艳 滕晓春 滕笛 关海霞 李玉姝 金迎 于晓会 范晨玲 杨帆 戴红 于扬 李佳 陈彦彦 赵冬 胡凤楠 毛金媛 谷晓岚 杨榕 佟雅洁 王微波 高天舒 李晨阳 滕卫平 《中华内分泌代谢杂志》2004,25(1):260-263
Objective To clarify the effect of iodine intake on serum thyroglobulin (Tg). Methods A 5-year prospective study was conducted in the 3 different iodine intake areas in China [Panshan (miht deficiency) ,Zhangwu (more than adequate) and Huanghua (excess)]. A total of 3 099 people with normal serum levels of Tg in 1999 were followed and 2 448 of these participants were feasible to be observed in 2004 and included in the present study. The serum levels of Tg, thyraglobulin antibody(TgAb), thyroid peroxidase antibody(TPOAb) and TSH, thyroid volume, family and personal histories of thyroid diseases were measured and inquried. The general linear model (GLM) was used to explore the determinants of Tg. Results Among the study population at baseline, serum Tg were significantly different in three areas [7.5 (4.4-13. 1) μg/L at Panshan, 6.8 (3.6-11.2)μg/L at Huanghua, 5.9 (3.2-10.7) μg/L at Zhangwu, P<0.01]. They were associated with age, sex and the rate of positive TgAb, abnormal thyroid volume, abnormal TSH and positive personal history of thyroid diseases, in order to control the effects of confounding factors, the data from 1856 subjects with thyroid-related indexes all in normal range and without personal history of thyroid diseases were analyzed to clarify the effect of iodine intake on Tg. The serum Tg among three areas were significantly different in both 1999 and 2004, they were all increased in 5 years with significant augment (△ Tg) among the three areas[3.1 (-0.2-8.0) μg/L at Panshan, 3.5 (0.5-9.0)μg/L at Huanghua vs 2. 5(0.3-6.1) μg/L at Zhangwu,P<0.01]. The GLM analysis revealed that age, Tg and TSH levels at baseline were the determinants of △Tg in addition to iodine intake. Conclusion Iodine intake is a dominant determinant of serum Tg. Age and TSH should also be considered while indicating iodine intake by serum Tg. 相似文献
37.
史晓光 崇巍 单忠艳 滕晓春 滕笛 关海霞 李玉姝 金迎 于晓会 范晨玲 杨帆 戴红 于扬 李佳 陈彦彦 赵冬 胡凤楠 毛金媛 谷晓岚 杨榕 佟雅洁 王微波 高天舒 李晨阳 滕卫平 《中华内分泌代谢杂志》2005,25(1):260-263
Objective To clarify the effect of iodine intake on serum thyroglobulin (Tg). Methods A 5-year prospective study was conducted in the 3 different iodine intake areas in China [Panshan (miht deficiency) ,Zhangwu (more than adequate) and Huanghua (excess)]. A total of 3 099 people with normal serum levels of Tg in 1999 were followed and 2 448 of these participants were feasible to be observed in 2004 and included in the present study. The serum levels of Tg, thyraglobulin antibody(TgAb), thyroid peroxidase antibody(TPOAb) and TSH, thyroid volume, family and personal histories of thyroid diseases were measured and inquried. The general linear model (GLM) was used to explore the determinants of Tg. Results Among the study population at baseline, serum Tg were significantly different in three areas [7.5 (4.4-13. 1) μg/L at Panshan, 6.8 (3.6-11.2)μg/L at Huanghua, 5.9 (3.2-10.7) μg/L at Zhangwu, P<0.01]. They were associated with age, sex and the rate of positive TgAb, abnormal thyroid volume, abnormal TSH and positive personal history of thyroid diseases, in order to control the effects of confounding factors, the data from 1856 subjects with thyroid-related indexes all in normal range and without personal history of thyroid diseases were analyzed to clarify the effect of iodine intake on Tg. The serum Tg among three areas were significantly different in both 1999 and 2004, they were all increased in 5 years with significant augment (△ Tg) among the three areas[3.1 (-0.2-8.0) μg/L at Panshan, 3.5 (0.5-9.0)μg/L at Huanghua vs 2. 5(0.3-6.1) μg/L at Zhangwu,P<0.01]. The GLM analysis revealed that age, Tg and TSH levels at baseline were the determinants of △Tg in addition to iodine intake. Conclusion Iodine intake is a dominant determinant of serum Tg. Age and TSH should also be considered while indicating iodine intake by serum Tg. 相似文献
38.
史晓光 崇巍 单忠艳 滕晓春 滕笛 关海霞 李玉姝 金迎 于晓会 范晨玲 杨帆 戴红 于扬 李佳 陈彦彦 赵冬 胡凤楠 毛金媛 谷晓岚 杨榕 佟雅洁 王微波 高天舒 李晨阳 滕卫平 《中华内分泌代谢杂志》2002,25(1):260-263
Objective To clarify the effect of iodine intake on serum thyroglobulin (Tg). Methods A 5-year prospective study was conducted in the 3 different iodine intake areas in China [Panshan (miht deficiency) ,Zhangwu (more than adequate) and Huanghua (excess)]. A total of 3 099 people with normal serum levels of Tg in 1999 were followed and 2 448 of these participants were feasible to be observed in 2004 and included in the present study. The serum levels of Tg, thyraglobulin antibody(TgAb), thyroid peroxidase antibody(TPOAb) and TSH, thyroid volume, family and personal histories of thyroid diseases were measured and inquried. The general linear model (GLM) was used to explore the determinants of Tg. Results Among the study population at baseline, serum Tg were significantly different in three areas [7.5 (4.4-13. 1) μg/L at Panshan, 6.8 (3.6-11.2)μg/L at Huanghua, 5.9 (3.2-10.7) μg/L at Zhangwu, P<0.01]. They were associated with age, sex and the rate of positive TgAb, abnormal thyroid volume, abnormal TSH and positive personal history of thyroid diseases, in order to control the effects of confounding factors, the data from 1856 subjects with thyroid-related indexes all in normal range and without personal history of thyroid diseases were analyzed to clarify the effect of iodine intake on Tg. The serum Tg among three areas were significantly different in both 1999 and 2004, they were all increased in 5 years with significant augment (△ Tg) among the three areas[3.1 (-0.2-8.0) μg/L at Panshan, 3.5 (0.5-9.0)μg/L at Huanghua vs 2. 5(0.3-6.1) μg/L at Zhangwu,P<0.01]. The GLM analysis revealed that age, Tg and TSH levels at baseline were the determinants of △Tg in addition to iodine intake. Conclusion Iodine intake is a dominant determinant of serum Tg. Age and TSH should also be considered while indicating iodine intake by serum Tg. 相似文献
39.
于晓会 范晨玲 单忠艳 滕晓春 滕笛 关海霞 李玉姝 崇巍 杨帆 戴红 何力 高庆军 于扬 李佳 陈彦彦 赵冬 毛金媛 谷晓岚 杨榕 姜雅秋 李晨阳 滕卫平 《中华内分泌代谢杂志》2001,25(1):255-259
目的 研究不同碘摄入量人群非毒性甲状腺肿(甲肿)和非毒性甲状腺结节的流行病学特点及影响其发生、发展和转归的因素.方法 2004年对盘山(长期轻度碘缺乏)、彰武(碘缺乏基础上补碘至碘超足量)和黄骅(长期碘过量)社区于1999年参加本课题组流行病学研究并进行甲状腺B超检查的人群(3 385人)进行甲状腺疾病的随访调查.结果 (1)盘山、彰武和黄骅社区弥漫型甲肿的累积发病率分别为7.1%、4.4%和6.9%,盘山和黄骅均显著高于彰武(均P<0.01);结节型甲肿的累积发病率分别为5,0%、2.4%和0.8%,盘山的发病率最高(P<0.01).(2)三社区甲状腺单发结节的累积发病率分别为4.0%、5.7%和5.6%,多发结节的累积发病率分别为0.4%、1.2%和1.0%.(3)基础碘缺乏、碘过量、甲状腺自身抗体(thyroid autoantibody,TAA)阳性是甲肿发生的独立危险因素.(4)彰武初访时TAA阳性人群非毒性甲肿的发生率显著高于TAA阴性人群(P<0.01),盘山和黄骅无显著差异.(5)三社区非毒性弥漫型甲肿维持人群和黄骅非毒性结节型甲肿维持人群随访前后TAA阳性率均高于同社区正常人群(P<0.05).结论 碘缺乏和碘过量均有可能使甲肿的发病率增加.碘缺乏社区结节型甲肿高发,弥漫型甲肿是碘过量社区甲肿发牛的主要形式.甲状腺自身免疫与甲肿的发生和维持相关,这种相关性在历史上为碘缺乏而后过度补碘的社区更明显. 相似文献
40.
于晓会 范晨玲 单忠艳 滕晓春 滕笛 关海霞 李玉姝 崇巍 杨帆 戴红 何力 高庆军 于扬 李佳 陈彦彦 赵冬 毛金媛 谷晓岚 杨榕 姜雅秋 李晨阳 滕卫平 《中华内分泌代谢杂志》2004,25(1):255-259
目的 研究不同碘摄入量人群非毒性甲状腺肿(甲肿)和非毒性甲状腺结节的流行病学特点及影响其发生、发展和转归的因素.方法 2004年对盘山(长期轻度碘缺乏)、彰武(碘缺乏基础上补碘至碘超足量)和黄骅(长期碘过量)社区于1999年参加本课题组流行病学研究并进行甲状腺B超检查的人群(3 385人)进行甲状腺疾病的随访调查.结果 (1)盘山、彰武和黄骅社区弥漫型甲肿的累积发病率分别为7.1%、4.4%和6.9%,盘山和黄骅均显著高于彰武(均P<0.01);结节型甲肿的累积发病率分别为5,0%、2.4%和0.8%,盘山的发病率最高(P<0.01).(2)三社区甲状腺单发结节的累积发病率分别为4.0%、5.7%和5.6%,多发结节的累积发病率分别为0.4%、1.2%和1.0%.(3)基础碘缺乏、碘过量、甲状腺自身抗体(thyroid autoantibody,TAA)阳性是甲肿发生的独立危险因素.(4)彰武初访时TAA阳性人群非毒性甲肿的发生率显著高于TAA阴性人群(P<0.01),盘山和黄骅无显著差异.(5)三社区非毒性弥漫型甲肿维持人群和黄骅非毒性结节型甲肿维持人群随访前后TAA阳性率均高于同社区正常人群(P<0.05).结论 碘缺乏和碘过量均有可能使甲肿的发病率增加.碘缺乏社区结节型甲肿高发,弥漫型甲肿是碘过量社区甲肿发牛的主要形式.甲状腺自身免疫与甲肿的发生和维持相关,这种相关性在历史上为碘缺乏而后过度补碘的社区更明显. 相似文献