圆当归根中钙拮抗活性成分的提取溶媒选择

在民间药用的伞形科植物中含有香豆素,它们对心脏、血液循环、平滑肌、中枢神经系统和内分泌有作用。圆当归Angelicaarchangelica L.根中含香豆素。本文用20种溶媒提取圆当归,1g干燥根粉,分别用50ml溶媒,在室温超声提取10min。各提取物经薄层分离,用薄层扫描光密度分析法,测定极性和非极性香豆素的量。以异搏定为阳性对照,用大鼠垂体GH_4C_1细胞,测定其去极化诱导~(45)Ca~(2+)的吸收,由提取物对~(45)Ca~(2+)吸收的     

紫外线照射引起血管内皮细胞损伤及其对TM活性的影响

本研究以紫外线作为损伤因素,并加以定量,以观察紫外线照射对血管内皮细胞的影响。结果表明,在不同程度的紫外线作用下,血管内皮细胞出现变园浮起、细胞溶解的不同的形态变化特征,当照射量大于1J/cm~2时,其存活率显著降低(P<0.01)。同时,在紫外线照射作用下,内皮细胞表面的血栓调节蛋白(Thrombomodulin简称TM)活性降低,其降低程度与照射量及照射后经过的时间有关。0.1J/cm~2照射量组24小时后可见明显下降(P<0.05);1J/cm~2照射量组3小时后显著降低(P<0.01);13.3J/cm~2照射量组照射后立即测定TM活性.可见显著降低(P<0.01),且随着时间的增加呈持续下降趋势。     

蒙医心刺痛与变异性心绞痛ST段电交替——附1例报告

本文探讨变异性心绞痛ST段电交替的发生机理,全面观察及分析1例43岁男性变异性心绞痛患者Holter记录情况及应用钙离子拮抗剂和硝酸类药物的治疗效果,提示患者可能由自主神经活动变化诱发冠状动脉痉挛所致的急性心肌缺血。变异性心绞痛ST段电交替现象反映了心电不稳定状态,可能为心肌复极不一致的折返所致,同时与蒙医心刺痛对比分析认为可将其归属于蒙医心刺痛之赫依性心刺痛范畴。     

香杨梅果实渗出物和C-甲基二氢查耳酮化合物的抗氧化活性

从香杨梅 Myrica gale L.果实渗出物的乙醚提取物中可分出一系列 C-甲基二氢查耳酮化合物,其中香杨梅酮 A(Myrigalon A,MyA)和香杨梅酮 B(MyB)是二个主要类黄     

荞麦精制提取物对信号转导变异通道中蛋白激酶的影响

蛋白激酶是控制细胞生长和分化的关键成分,丝氨酸/苏氨酸(Ser/Thr)或酪氨酸基团磷酸化是调节细胞病变蛋白的共用通道,它们的蛋白激酶形成转导变异信号的调节网。信号转导变异迷乱是某些增生性疾病的标志。在有些癌中已发现致瘤活性的酪氨酸蛋白激酶(PTK)。阻断影响癌细胞生长的关键信号蛋白是开展抗癌治疗的途径,因此将寻找 PTK 抑制剂列为开发抗癌剂的方法。     

关于人参有效成分研究的初步报告

<正> 贵重药物人参的化学成分在目前还很少研究。由于对人参有效成分的性质不了解,就不可能选择它们的合成类似化合物,并且在制订人参根内有效成分的化学鑑定法上也有很大的困难。应用化学鑑定方法,可使在种植场上栽培珍贵的、有商品价值的人参根的工作易于进行。但在目前,还只能按照人参根的生物学的活性来进行估价。近来,苏联的医师们和药理学者们在广泛地研究人参的兴奋作用和紧张作用。在人参的     

产后出血136例分析

产后出血为产妇死亡三大原因之一,如何降低产后出血的发生率和减少死亡率,是全体产科工作者当前迫切的任务。本文拟将太原地区的几个主要医院的最近期间病例,加以初步分析并提出预防措施初步意见,以供我省广大地区全体产科工作者参考,浅陋之处多加指正。本文由于最初草拟登记表格时间匆促,有很多项目遗漏,加之我们的病历保管不够完善,送回登记表     

经下腔静脉放置冠状静脉窦电极导管对操作者放射剂量影响的研究

Objective To evaluate and compare the dosages of operator-incurred-radiation during the implantation of coronary sinus (CS) catheter between the approaches through inferior vena cava (IVC) with the steerable catheter and through supra vena cava (SVC) with the fixed curve catheter. Methods Two hundred and two patients were divided into two groups according to the different approaches of CS catheter insertion. IVC group (n = 122) :a deca-polar catheter with steerable curve was placed into CS through the femoral vein and the IVC. SVC group (n =80) :a fixed curve deca-polar catheter was inserted into CS through the jugular vein and the SVC. There was no obvious difference in gender, age, and echocardiogram between the two groups. All procedures were performed by the same three operators. The exposure time of each case and the dosage of operator-incurred-radiation during the procedure were measured. Results The catheters were positioned successfully inl20 patients in the IVC group and in all patients in the SVC group. The 2 failured in the IVC group were also failed in by attempting through SVC with fixed curve catheter. There was no significant difference in the exposure time between IVC group and SVC group[( 105 ± 12)s and ( 108 ± 19)s,P =0. 925]. The per sec operator-incurred-radiation was 0. 25 × 10-2 uGy/s in WC group and 1.38 × 10 -2 uGy/s in SVC group. This lead to significant decrease in the dosage of operator-incurred-radiation in IVC group[(0. 30 ± 0. 04) uGy vs ( 1.49 ±0. 27) uGy,P ＜ 0. 001]. No cardiac or vascular complication was observed in both groups. Conclusions Insertion of coronary sinus catheter through IVC with the steerable catheter is associated with significantly less radiation than that through SVC with the fixed curve catheter without increasing time of the procedure.     

动态心电图监测起搏器介导性心动过速的诊断及鉴别诊断

起搏器介导性心动过速（PMT）是双腔起搏器在临床应用中最常见及最重要的并发症之一。现收集我院动态心电图监测DDD起搏器出现的起搏器介导性心动过速等9例,就其心电图表现加以探讨,目的是熟悉心电图特点,提高对这一合并症诊断与鉴别诊断的认识,对指导临床进行处理及起搏器程控有着重要意义。     

鲍温病并皮肤念珠菌病1例

患者女,56岁,哈尼族,因右背部发生斑块、结节伴疼痛3年,破溃2月余于2008年11月15日来诊。患者3年前无原因感右背部发生红斑、结节伴疼痛,一直未进行治疗。3月前到民间医生处行拔火罐、挑治及外敷草药3次后约10天,皮损破溃、疼痛加剧。