张小萍治疗肝胆病验案举隅

<正>张小萍教授是国家级名中医,江西省名中医,主任中医师,博士生导师,从事中医临床、教学、科研50余年,擅长治疗内科疾病,尤其对脾胃肝胆科的常见病及疑难病诊治均有独到的经验。现将其治疗肝胆病验案列举一二,与同道分享。1慢性乙型病毒性肝炎陈某,男,34岁。2013年5月17日初诊。患者以神疲乏力,两胁胀闷不舒,小便黄2周就诊。患者既往有慢性病毒性乙肝病史10余年。现     

肝宁方治疗肝硬化脾功能亢进30例

[目的]观察肝宁方治疗肝硬化脾功能亢进症疗效。[方法]将60例随机分为两组,肝宁方组(治疗组)和复方鳖甲软肝片组(对照组)。[结果]治疗组在改善中医症候、体征积分,尤对乏力、纳呆及大便不调等症状均较对照组为优(P<0.05);治疗后白细胞、血小板计数两组均有升高,治疗组差异显著(P<0.05),对照组不明显(P>0.05),治疗组优于对照组(P<0.05);治疗组患者门静脉内径、脾静脉内径在治疗3个月后均有明显改善(P<0.05),两组间比较差异不显著(P>0.05)。[结论]肝宁方治疗肝硬化脾功能亢进症,不但可以改善患者的中医症候、体征积分,并有升高患者血小板和白细胞作用。     

胃宁颗粒抑制胃癌转移的实验研究

目的:体外观察胃宁颗粒抑制胃癌转移作用.方法:MTT法检测胃宁颗粒低、中、高剂量含药血清对人胃癌细胞SGC-7910与FN的黏附的抑制作用;重组基底膜细胞侵袭实验观察胃宁颗粒低、中、高剂量含药血清对人胃癌细胞SCC-7910侵袭及迁移的抑制作用.结果:胃宁颗粒低、中、高剂量含药血清处理组吸光值与对照组相比,差异有显著性意义(P＜0.01);胃宁颗粒低、中、高剂量含药血清处理后通过滤膜细胞数与对照组相比,差异有显著性意义(P＜0.05);胃宁颗粒高剂量含药血清处理后划痕区间距与对照组相比,差异有显著性意义(P＜0.01).结论:胃宁颗粒能抑制胃癌细胞黏附、侵袭与迁移,具有抑制胃癌转移的作用.     

A clinical study of Weining Granules in the treatment of gastric precancerous lesions

OBJECTIVE:To investigate the clinical effects of Weining Granules on gastric precancerous lesions(GPLs).METHODS:120 patients with GPLs were randomly assigned in a 1:1 ratio to receive Weining Granules(trial group) or the comparator Weifuchun tablets(control group) for 6 months.Outcomes were compared between the two groups including:overall response;gastroscopically-determined response;pathologically-confirmed response;eradication of Helicobacter pylori(HP);microvessel density(MVD) in the gastric mucosa;expression of vascular endothelial growth factor(VEGF);interleukin 2(IL-2);interleukin 6(IL-6);T lymphocyte subsets;immunoglobulins;symptom scores;quality of life(QOL);and adverse reactions.RESULTS:Patients in the trial group had a significantly higher(P<0.05) overall response rate(81.7%) as compared with those in the control group(63.3%).Relative to treatment with Weifuchun tablets treatment with Weining Granules resulted in a significant improvement(P<0.05) in the scores for gastric pain,distension and stuffiness in the hypochondrium,and anorexia.As compared with the tablets the Granules were associated with a significantly higher overall gastroscopically-determined response rate(78.3%;P<0.05).Pathological examination of tissue samples indicated that 61.7% of patients receiving the granules were cured with an overall response rate of 75.5%;these rates were significantly higher than in the control group(P<0.05).In comparison with patients receiving the tablets,those given the granules were significantly more likely to have their HP eradicated(75.0% vs.51.4%;P<0.05).Improvements in MVD,VEGF,CD4+,CD4+/CD8+,IL-2,IL-6 and IgG were significantly greater with the Weining Granules than with the Weifuchun tablets(P<0.05 or P<0.01).After follow-up of 1 year,17.5% of patients in the trial group relapsed as compared with 39.5% in the control group(P<0.05).Relative to the control group,the trial group showed significantly greater improvements in physical,psychological and social relationships,and in environmental domains(P<0.05 or P<0.01).No significant adverse reactions were observed during treatment.CONCLUSION:The Weining Granules appear to be effective in improving the gastric precancerous state and the main symptoms,in inhibiting angiogenesis,enhancing immune function and QOL,and in reducing 1-year relapses.In addition,this preparation seems to be associated with a low risk of adverse events,making it a safe and efficacious option for the treatment of GPLs.     

复方阿胶浆含药血清对胃癌SGC7901细胞Bcl-2基因表达作用实验

目的:探讨复方阿胶浆含药血清对肿瘤凋亡抑制基因Bcl-2表达影响。方法:采用血清药理学方法,开展了含复方阿胶浆血清对胃癌SGC7901细胞体外培养,通过流式细胞仪检测细胞Bcl-2基因表达的变化。结果:含复方阿胶浆血清可显著降低凋亡抑制基因Bcl-2表达,与对照组相比有显著性差异(P<0.01)。结论:含复方阿胶浆血清可显著降低胃癌细胞Bcl-2基因表达,因而具有诱导肿瘤细胞凋亡的作用。     

三磷酸胞苷注射液的稳定性研究

三磷酸胞苷(CTP)是生物体内的一种高能化合物,它在机体内参与核酸和重要磷脂类的合成代谢,有健全、调节神经组织的作用,又有改善脂肪代谢紊乱以防止和缓解血管硬化等作用。适用于治疗脑外伤后遗症、神经损伤所致的意识障碍、瘫痪以及继发性     

提升医院档案管理水平促进科学化管理

摘要：医院档案及其管理工作在医院建设中具有关键作用，它为行政部门提供医疗及管理人才基础信息，为职工劳动工资制度改革、专业技术职称评定和福利及提拔任用等提供依据。所以，加强人事档案管理，提升人事档案管理理念，实现档案管理科学化、规范化、现代化。     

张小萍教授从脾胃气化论治溃疡性结肠炎

介绍了张小萍教授运用脾胃气化学说论治溃疡性结肠炎的临床经验。认为该病病机为本虚标实,本虚为脾虚,标实为湿热、疫毒、寒湿侵犯肠腑。其发生发展与脾胃的纳化失常、燥湿失衡、气机升降出入失调有关,临床常以调升降,清内邪;理出入,抗外邪;顾纳化,复脾胃;兼燥湿,固肠腑等法治疗。      

谈仙人掌的营养和药理作用

仙人掌俗名霸王树、玉芙蓉。主要生长在海滨沙滩等处。人们也常将其栽在花园或花盆中作为观赏药用植物。近来人们对仙人掌特别青睐。其一,仙人掌有一种奇特蓄水本能,白天在阳光照射下,为避免水分大量蒸发,它能自动关闭气孔,到晚上打开气孔吸收二氧化碳,放出氧气。室内栽培仙人掌可以增加新鲜空气,使室内中负离子浓度增加起到调节净化空气的作用。其二,仙人掌茎含