新生儿体重与母体孕期健康状况的关系

目的:探讨新生儿体重与母体4项健康指标的关系,为指导孕妇保健提供依据。方法:对466例新生儿体重及母体分娩前营养物质摄入情况、体质指数(BMI)、分娩时年龄、母体妊娠时间的关系进行统计分析。结果:母体总能量摄入量高、脂肪摄入量高、BMI超过正常值、过期产的母体娩出体重偏大或巨大儿的几率高;母体蛋白质、碳水化合物的摄入量、分娩时年龄对新生儿体重无明显影响。结论:母体总能量和脂肪摄入量、BMI、妊娠时间等因素对新生儿体重有明显影响,加强产前孕妇的健康指导,对预防儿童肥胖保证儿童健康成长具有重要意义。     

多排螺旋CT诊断子宫平滑肌瘤的价值

目的分析子宫肌瘤的CT影像,探讨其诊断价值。方法本文报告156例经CT检查并经手术和病理证实的子宫肌瘤。结果CT表现为子宫不同程度增大及实质性的肿块,边界清楚,内可见低密度、钙化灶。结论CT对诊断子宫肌瘤有较高价值。     

中西医结合康复治疗37例小儿脑性瘫痪疗效观察

目的：探讨脑性瘫痪(CP)患儿的中西医结合治疗的效果。方法：对37例患者采用PT、穴位注射、针灸、按摩手段进行治疗。结果：通过进行综合康复治疗，疗效满意，有效率为62％。结论：中西医结合治疗CP效果满意、     

新疆阿克苏地区重点人群碘营养和智力水平调查

Objective To investigate the iodine nutritional status of school children, lactating women and infants in iodine deficient areas of Baicheng and Wushi Counties in Xinjiang Autonomous Region. Methods According to the geographic location of east, south, west and north of county, 10 primary schools of 8 townships were selected. In each school, 10 children among each gender and age group from 8 to 10 years old were selected. A total of 300 school children were chosen. One hundred and four infants aged 0-2 years old and their mother were selected in 8 townships. Iodine content in edible salt at household level, the urinary iodine in school children and lactating women, total goiter rate(TGR) and the status of the intelligence quotient (1Q) of school children, the status of psychological development of infants were observed. Direct titration assay for testing the salt iodine, colorimetric ceric-arsenic assay and vitriolic ammonium assimilation were used for testing urinary iodine. The size of thyroid gland was measured by palpation. The Combined Raven Test for Chinese Rural was used to test the IQ. The psychological development of infants was tested by Danver Development Screening Test (DDST). Results The coverage rate of iodized salt at household level was 73.1% (123/182), however, the proportion of households using adequately iodized salt was 64.1% (118/182). The medium of urinary iodine in school children was 103.7 μ/L, with 47.8%(75/157) less than 100 μg/L and 28.0% (44/157) less than 50 μg/L; it was 123.0 μg/L in Baieheng County, with 44.4%(28/63) less than 100 μg/L and 33.3%(21/63) less than 50 μg/L; it was 100.3 μg/L in Wushi County, 50.0%(47/94) less than 100 μg/L and 24.5%(23/94) less than 50 μg/L. The medium of urinary iodine in locating women was 143.3 μg/L, it was 119.7 μg/L and 184.6 μg/L in Baicheng and Wushi Counties, respectively. The total rate of goiter in school children was 14.3%(43/300), it was 10.8%(13/120) and 16.6%(30/180) in Baicheng and Wushi Counties, respectively. The average IQ in school children was 80.6±11.6, it was 83.0±11.6 and 79.0±11.7 in Baicheng and Wushi Counties, respectively. The proportion of mental retardation in school children (IQ≤69) was 13.0% (39/300), it was 6.7% (8/120) and 17.2%(31/180) in Baicheng and Wushi Counties, respectively. In addition, the proportion of psychological development in infants being normal, suspicious and abnormal was 78.8%(82/104), 12.5% (13/104) and 8.7%(9/104), respectively. Conclusion This study confirms the fact that there is also existence of mental retardation in children and infants, caused by iodine deficiency.     

G2.0聚酰胺-胺树状大分子及其水杨醛修饰物体外释药性能的研究

目的考察G2.0聚酰胺-胺树状大分子(PAMAM)及水杨醛修饰物(PAMAM-SA)的释药机制。方法用紫外可见分光光度法检测2种大分子环境敏感性及对氧氟沙星的增溶作用。氧氟沙星含量测定采用HPLC法:ODS-C18色谱柱(150mm×4.6mm,5μm);流动相为乙腈、三乙胺溶液(磷酸调pH 4.0)(14∶86);检测波长294nm;流速1.0mL·min-1;柱温40℃。结果氧氟沙星单独释放80%需要2h,G2.0PAMAM-氧氟沙星复合物释放氧氟沙星80%需要5h,G2.0PAMAM-SA-氧氟沙星复合物释放氧氟沙星80%需要2.5h。结论 2种大分子具有环境敏感性,对氧氟沙星具有增溶、缓释作用,2种复合物形成是大分子的氨基阳离子与氧氟沙星的羧基阴离子之间静电作用的结果。     

丹红注射液辅助治疗不稳定性心绞痛的临床效果观察

目的探讨丹红注射液辅助治疗不稳定性心绞痛的临床效果。方法不稳定性心绞痛患者110例,随机分成对照组与治疗组各55例,对照组患者采用常规治疗,治疗组患者在常规治疗的基础上加丹红注射液治疗,观察其临床效果。结果治疗组患者总有效例数为52例,总有效率为94.5%,明显高于对照组的60.0%。结论丹红注射液辅助治疗不稳定性心绞痛临床效果显著,副作用少,价格低廉,值得在临床推广应用。     

不同程度碘缺乏母鼠对胎鼠脑双皮质素、突触素p38基因表达的影响

目的　探讨不同程度碘缺乏引起的母亲甲状腺功能异常对胎儿脑发育标志物双皮质素(DCX)、突触素p38基因表达的影响.方法　Wistar雌鼠按每日总碘供给量(自来水中添加不同浓度的KI,食用低碘饲料)分为碘适宜组(AI)、轻度缺碘组(MiID)、中度缺碘组(MoID)、重度缺碘组(SID).喂养3个月后交配,检测妊娠20天母鼠尿碘、甲状腺组织学、血清TSH和甲状腺激素(TH)水平,胎脑DCX和突触素p38 mRNA和蛋白表达水平.结果　(1)碘缺乏组母鼠尿碘随饮食碘供给量的减少而降低.与AI组比较,SID组孕鼠血清TSH水平升高[(2.95±1.70对1.31 ±0.55)mIU/L,P＜0.05],TT4[(14.3±4.1对28.4±19.3)nmol/L,P＜0.05]和FT4[(10.8±3.6对20.2±8.0)pmol/L,P＜0.01]降低;MoID、MiID组TSH水平呈升高趋势,TT4和FT4呈降低趋势;TT3、FT3水平各组差别无统计学意义.(2)SID组甲状腺呈现典型的小滤泡增生性甲状腺肿改变、胶质缺如;MoID组呈中度小滤泡增生性变化、胶质减少;MiID组仅呈轻度细胞增殖,但滤泡大小与AI组相似、胶质减少不明显.(3)与AI组比较,各缺碘组胎脑DCX mRNA表达呈升高趋势,MoID组升高有统计学意义(P＜0.01),蛋白表达在各碘缺乏组均明显上调(P＜0.01);而突触素p38 mRNA和蛋白表达在各碘缺乏组均显著下调(P＜0.01).结论 母亲碘缺乏使胎儿脑神经元发育和突触生长受到损伤,其损伤随母亲的缺碘程度而逐渐加重;尤其母亲轻、中度碘缺乏就能明显抑制胎儿脑发育应引起关注.     

PICU专科护士临床培训的实践与管理

目的探讨理论培训与实践训练并重的培训模式在儿科重症监护室(PICU)新护士培训中的应用效果。方法对50名PICU新护士进行3个月,分三阶段的培训,理论与实践相结合。比较护士培训前后理论知识、操作技能及临床综合能力的差异。结果培训后50名新护士的理论知识、操作技能考核成绩显著提高,与培训前比较差异有统计学意义(P0.01)。结论有计划,系统、规范的理论与实践训练并重的培训,能迅速提高新护士的理论知识以及临床综合素质。     

剖宫产切口瘢痕缺损妊娠风险评估与预防

剖宫产切口瘢痕缺损（cesarean scar diverticulum,CSD）是剖宫产术后的远期并发症之一,临床常见症状除阴道不规则流血、不孕、盆腔痛等症状外,再次妊娠后的产科风险也引起了临床医生的关注。文章围绕CSD的分类与生育风险评估、CSD再次妊娠风险评估、预防CSD及相关妊娠风险等三方面内容结合我国2019年制定的CSD专家共识,将CSD的分类、分度与再次妊娠时的生育风险、生殖结局及如何预防等进行阐述与讨论,为临床评估与处理此类疾病提供依据。     

西咪替丁联合孟鲁司特钠治疗小儿过敏性紫癜疗效观察

目的:观察西咪替丁联合孟鲁司特钠治疗小儿过敏性紫癜的临床效果。方法:选择2016 年3 月至2017 年5 月我院诊治的78 例过敏性紫癜患儿为研究对象,随机分为对照组和观察组各39 例。对照组采用西咪替丁治疗,观察组则采用西咪替丁联合孟鲁司特钠治疗,比较两组患儿治疗后1 周及2 周不同时间点的临床总有效率、不良反应发生率、症状体征改善时间、治疗前后不同时间点的变态反应指标及细胞因子水平。结果:观察组患儿治疗后1 周及2 周的临床总有效率高于对照组(P<0.05),症状体征改善时间短于对照组患儿(P<0.01),两组不良反应发生率比较差异无统计学意义(P>0.05)。治疗前两组患儿变态反应指标及细胞因子水平比较差异无统计学意义(P>0.05),治疗后不同时间观察组患儿的变态反应指标及细胞因子水平均优于对照组,差异有统计学意义(P<0.01)。结论:西咪替丁联合孟鲁司特钠治疗小儿过敏性紫癜临床效果较好,应用价值较高.