Effects of Tongguan Capsule(通冠胶囊)on Post-myocardial Infarction Ventricular Remodeling and Cardiac Function in Rats

<正>Objective:To observe the effects of Tongguan Capsule(通冠胶囊,TGC) on post-myocardial infarction ventricular remodeling and heart function in rats.Methods:A rat model of acute myocardial infarction (AMI) was established by coronary ligation.Experimental rats were randomized to 4 groups including three model groups(Group A:captopril 5 mg/kg·day,n=7;Group B:TGC 10 g/kg·day,n=7;and Group C:placebo, n=8),and a sham-control group(Group D:blank control,n=6).Animals were treated for 4 weeks.The cardiac function of rats was assessed at the end of the experiment based on left ventricular ejection fraction(LVEF) and left ventricular short axis fractional shortening(LVFS) detected by colored echocardiography;meanwhile, the condition of ventricular remodeling was observed through the levels of left ventricular mass(LVM),plasma aldosterone(ALD),myocardial angiotensinⅡ(AngⅡ) and myocardial collagen measurements.Results:At the end of the experiment,LVEF and LVFS in Group A and B were improved significantly,while those in Group C were unchanged,the LVEF in Group A,B,C,and D was 0.57±0.46,0.61±0.08,0.36±0.55 and 0.76±0.02,respectively;and their LVFS was 0.31±0.52,0.34±0.04,0.23±0.57 and 0.45±0.03,respectively.The difference was statistically significant when comparing the two indexes in Group A and B with those in Group C and D(P0.05).LVM,levels of plasma ALD and myocardial AngⅡwere lower in Group A and B than in Group C,but a comparison between Group A and B showed an insignificant difference in lowering LVM and ALD,while the lowering of AngⅡwas more significant in Group B than in Group A(754.7±18.7 pg/mL vs 952.6±17.6 pg/ mL,P0.05).Morphological examination showed that in Group A and B the swollen myocardial cells had shrunk, with regularly arranged myocardial fibers and decreased collagen proliferation,but the improvements in Group B were more significant.Conclusion:TGC could markedly improve the post-infarction ventricular remodeling and cardiac function in rats,showing that the efficacy was better than or equal to that of captopril.     

嗜铬细胞瘤37例报告

本文报告经病理证实的嗜铬细胞瘤37例,尿儿茶酚胺和VMA定量为诊断依据,酚妥拉明药物筛选有一定价值,肿瘤定位采用CT和B超取得良好效果,术前苯苄胺准备,麻醉和术中血压升高可用酚妥拉明控制血压。     

我国人脏器正常重量统计分析

我国人脏器正常重量,过去很少有报告,一般都引用欧美的脏器正常重量作标准,但其重量是否与我国人实际相符,这是我国病理工作者要认真解决的基本问题之一. 资料我们统计了本教研室1949年到1982年的2253例尸检资料,其中成年组(18～60岁)     

膀胱癌与人造糖(综述)

人造糖包括糖精(Sauharine)和仙客来甙盐(Cydamate),是一种非营养性糖,不会导致食后体重增加和血中胆固醇量升高,亦不会加重糖尿病,是一种很好的蔗糖代用品,最适宜于肥胖者、高脂血症、糖尿病和龋齿患者食用。人造糖食后由肠完全吸收,迅速由尿原样排出,在体内不起代谢变化,由肾排出的方式是通过肾小球滤过和肾小管分泌相结合,肾小管不重吸收。Kojima 等(1966)发现一志愿者进食大量仙客来甙盐后,有0.7%转变为有致癌作用的环己胺。以后相继有人在动物实验和在人类中证明大约有1/10的动物或人有这一代谢过     

原发性肝癌旁肝组织中Kupffer细胞数量和形态的改变

用溶菌酶PAP染色、内源性过氧化物酶组化染色和电镜观察方法,对15例原发性肝癌旁肝组织中的Kupffer细胞进行了定量观察。另取12例正常肝和11例单纯肝硬化作对照。结果发现癌旁肝组织中KCs较正常明显减少。将癌旁肝组织按有无肝硬化分类,还发现癌旁无肝硬化者KCs减少不明显,而癌旁肝硬化和单纯肝硬化一样,KCs都明显减少,且两者间无显著差别。提示肝癌对癌旁KCs的影响不大,癌旁KCs的减少主要与肝硬化有关。电镜下正常和癌旁肝组织中的KCs在形态上无明显差别。     

松果体部胚生殖细胞瘤颅外转移1例报告

我科于2900例尸检中偶见1例松果体部胚生殖细胞瘤颅外转移患者。患者男性,50岁。因视力障碍、头昏、头痛、进行性吞咽困难5个月,右上肢活动障碍半个月而入院。按结椤性脑膜炎治疗两个半月后,昏迷、全身衰竭、合并肺部感染而死亡。     

中青年急死1268例尸检分析

目的 妥我国中青年急死的特点。方法 从我国２２所医学院校或医院病理科和／或法医系登记的急死尸检资料，选出年龄在１５～５９岁之间的急死病例进行分析。结果 共选出１２６８例，男９５５例，女３１３例，男：女＝３：１。导致中青年急死前三位原因是：心血管系统疾病（３５．９％）、消化系统疾病（２１．９％）、原因不明者（１７．０％）。常见的几种疾病有冠状动脉性心脏病，大脑内出血，急性出血性胰腺炎。结论 中青年急     

急、慢性肝病肝细胞及不典型增生肝细胞的显微测量

本文用PAP法显示乙型肝炎表面抗原(HBsAg),并用显微测量的方法对23例HBV感染的急、慢性肝病和8例肝细胞不典型增生(LCD)分别进行了肝细胞胞体和胞核的直径测量,并计算其核浆比例.另取10例HCC和8例正常肝作对照.结果发现HBV感染的急性肝病肝细胞核浆比例正常,而HBV感染的各种慢性肝病肝细胞的核浆比例都较正常增大(P<0.05),介于正常肝细胞和HCC之间.此结果提示,HBV感染的急、慢性肝病肝细胞在形态学上存在差异,后者的核浆比例增大,可能是一种癌前病变.LCD的核浆比例也增大,介于正常肝细胞和HCC之间,也可能是一种癌前病变.     

用聚合酶链反应直接检测肝细胞癌组织中HBV DNA

介绍用肝细胞癌组织直接进行聚合酶链反应检测HBV DNA的方法。本法特异性强、灵敏度高,为肝细胞癌的病因学研究提供了新的实验手段。