盘龙七片配合关节注射治疗膝关节骨性关节炎的临床评价

膝关节骨性关节炎(Keen osteoarthritis,KOA),是中老年人的常见病,多发病,以膝关节疼痛,活动受限,关节肿胀及畸形为主要临床表现,治疗方法甚多,除手术外,基本上都是以消除症状,缓解疼痛,改善活动功能为主,自2007年6月～2008年6月,对门诊患者中采取单纯复方倍他米松关节内注射治疗及与盘龙七口服配合关节注射治疗进行对照观察,现报告如下.     

经典名方中桔梗药材"遵古"炮制的研究思路与探讨

古代经典名方研发过程中,处方药材的"遵古"炮制研究尤为重要,将处方药材炮制成与古代医籍原方记载保持一致,且符合现代应用标准的饮片,是经典名方研发工作的重要环节。本文以经典名方"升陷汤"中桔梗药材的炮制为例,对桔梗净制、水处理、切制及干燥工艺进行研究,须经过确立并验证炮制方法与工艺、工艺放大试验、中试生产等环节,考虑药材—饮片—标准煎液的相关性,最终确定药材质量标准。     

治疗宫颈病变而不影响生殖的新方法:宫颈环形电切术

目的：探讨宫颈环形电切术（LEEP）与阴道镜下多点活检在宫颈病变的诊断中互补，及其LEEP在宫颈病变治疗中的价值。方法：回顾分析因宫颈病变同时行宫颈细胞学检查，阴道镜下多点活检和LEEP的患者109例。采用自身对照法，对照LEEP和阴道镜下多点活检病理结果。结果：LEEP和阴道镜下多点活检的病理结果完全符合者86例（78.9%)，不符合者23例（21.1%)。LEEP后，因发现原位癌2例（1.9%)行全子宫切除术1例，行较大的宫颈锥形切除术1例。术后3个月随诊。无一例出现宫颈细胞学检查异常，LEEP的并发症为出血46例（42.2%)。结论：LEEP在宫颈病变的诊断和治疗中具有极其重的价值。对于宫颈病变的明确诊断与阴道镜下多点活检互为补充；对宫颈炎症，CINⅠ、CINⅡ、CINⅢ可提供操作简单，安全有效的治疗，并可保留生育功能；患者有宫颈细胞学检查结果再到门诊做阴道镜检查时，即可用LEEP进一步诊断和同时治疗，术后必须定期随访；本文中介绍几种处理并发症的经验。     

白细胞介素8在兔缺血再灌注脊髓损伤中的作用

目的 探讨兔缺血再灌注脊髓组织中白细胞介素8（IL-8）趋化诱导中性粒细胞（PMNL）的作用。方法 分非抗IL-8抗体组和抗IL-8抗体组，采用免疫组化和组织病理学方法，观察抗IL-8抗体使用前后再灌注脊髓组织中IL-8的表达及PMNL浸润情况。结果 再灌注12h，脊髓组织中IL-8呈强阳性表达并可见大量PMNL浸润，使用抗IL-8抗体后，组织中IL-8被清除，PMNL浸润明显减少。结论 缺血再灌注脊髓损伤中，IL-8可强烈地趋化诱导PMNI。在组织中的浸润，其在炎症反应引起的继发性损伤中发挥重要作用。     

强的松配合环磷酰胺冲击治疗难治性紫癜性肾炎的疗效观察

１９９２年～１９９７年间收治的２２例难治性紫癜性肾炎（ＨＳＮ）采用环磷酰胺（ＣＴＸ）冲击治疗，随访１２～３６个月效果满意，蛋白尿缓解总有效率８１８％，血尿有效率７７．３％，现报告如下。１　对象和方法１１　病例选择　对确诊为ＨＳＮ的患者先用标准激素治疗，强的松１ｍｇ·ｋｇ－１·ｄ－１×（６～８）周而效果差，蛋白尿＞２ｇ／ｄ并伴有血尿者，男性１４例，女性８例，年龄６～３０岁，平均１８岁，病程４个月～２年。１２　治疗方法１２１　ＣＴＸ冲击疗法　ＣＴＸ８～１２ｍｇ·ｋｇ－１·ｄ－１，连用２天…     

硝酸甘油和肝素联合应用治疗顽固不稳定型心绞痛45例

目的探讨一条有效的治疗顽固性不稳定型心绞痛的方法；方法应用肝素75-100mg，硝酸甘油5-10mg，加入10%葡萄糖成生理盐水250ml，静滴，15-20滴/min，每日一次，连用7-10天；结果临床总有效率达91.1%，显效率达68.9%，所获数据经X^2检验，疗效明显优于常规治疗（P<0.01），不良反应轻微；结论应用硝酸甘油和肝素治疗顽固性不稳定型心绞痛是一种安全有效的方法，值得推广。     

3D printing-assisted percutaneous balloon dilatation plasty for treatment of osteoporotic calcaneal fractures of Sanders type Ⅱ or Ⅲ in the elderly patients北大核心CSCD

Objective To compare the clinical efficacy between 3D printing-assisted percutaneous balloon dilatation calcaneal plasty (3D-PCP) and conventional open reduction and internal fixation (ORIF) via the extended lateral L-shaped approach in the treatment of osteoporotic calcaneal fractures of Sanders type Ⅱ or Ⅲ in the elderly patients. Methods Retrospectively analyzed were the data of 36 elderly patients with osteoporotic calcaneal fracture of Sanders type Ⅱ or Ⅲ who had been surgically treated at Department of Orthopaedics, Yixing People's Hospital from June 2012 to June 2018. According to their treatment methods, the patients were divided into a 3D-PCP group [16 cases, 9 males and 7 females with an age of (73.0 ± 3.4) years] and an ORIF group [20 cases, 8 females and 12 females with an age of (71.4 ± 2.6) years]. The 2 groups were compared in terms of hospital stay, operation time, intraoperative fluoroscopy frequency, suture removal time, weight bearing time, fracture healing time, visual analogue scale (VAS) for the surgical site 2 days and one year after surgery, American Foot and Ankle Surgery Association (AOFAS) ankle-hindfoot score, calcaneal imaging parameters (Böhler angle, Gissane angle, and length, width and height of the calcaneus axis) at 2 days and one year after surgery, and postoperative complications. Results There was no significant difference in the preoperative general data between the 2 groups, showing comparability (P > 0.05). All patients were followed up for 14 to 18 months (mean, 15.6 months). Compared with the ORIF group, the 3D-PCP group had significantly shorter hospital stay, significantly shorter operation time, significantly earlier suture removal, significantly earlier weight-bearing, significantly lower VAS scores at 2 days after surgery, significantly higher AOFAS ankle-hindfoot scores at one month after surgery, but significantly more times of intraoperative fluoroscopy (all P < 0.05). In all patients, the VAS scores at 2 days after surgery were significantly lower than those before surgery, and those at one year after surgery significantly lower than those at 2 days after surgery (P < 0.05). In all patients, the AOFAS ankle-hindfoot scores at one month after surgery were significantly higher than those before surgery (P < 0.001). In the ORIF group, the AOFAS ankle-hindfoot scores at one year after surgery were significantly higher than those at one month after surgery (P < 0.05), but in the 3D-PCP group there was no such a significant difference between one year and one month after surgery (P > 0.05). There was no significant difference in VAS score, AOFAS score, fracture healing time or postoperative imaging parameters between the 2 groups at one year after surgery (P > 0.05). There was no significant difference either in the incidence of complications between the 2 groups (P > 0.05). Conclusion In the treatment of osteoporotic calcaneal fractures of Sanders type Ⅱ or Ⅲ in the elderly patients, compared with conventional ORIF, 3D-PCP shows advantages of shorter operation time, minimal invasion, quicker incision healing, shorter hospital stay, earlier weight-bearing exercise, and better functional recovery but a disadvantage of increased times of intraoperative fluoroscopy. © 2022 Chinese Journal of Orthopaedic Trauma. All rights reserved.