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171.
铁玲罗永海汪常伟江华亚生江龚建齐李彦华 《中国中西医结合耳鼻咽喉科杂志》2023,(5):329-333
目的 分析新疆不同地区耳聋患者COCH基因突变位点、频率,并探讨其与肾虚血瘀型的关系。方法 确定新疆两个地区195例耳聋患者纳入病例组,包括:阿勒泰地区99例、哈密市96例;配对设计207例健康人为对照组,包括:阿勒泰地区104例、哈密市103例。所有受检者均收集外周血提取DNA,采用聚合酶链反应(PCR)产物直接测序方法进行COCH第4、5、12外显子基因突变检测,中医辨证分型为肾虚血瘀型患者和非肾虚血瘀型患者。结果 在COCH第12外显子上,测得3种基因突变形式:1760A>T、1791A>G、2461T>C;进一步比较发现,对照组三种基因突变形式中,哈密市维吾尔族与阿勒泰地区哈萨克族人群中2461T>C基因突变位点的差异具有统计学意义(P<0.05)。肾虚血瘀型患者占所有耳聋患者的58.5%。发生COCH基因突变均与不同地区及中医辨证分型存在线性相关(P<0.05)。结论 耳聋患者中肾虚血瘀型占比较高。新发现突变位点丰富了新疆COCH基因突变和多态性图谱,为进一步研究新疆耳聋遗传筛查和基因库的建立奠定基础。肾虚血瘀可能是COCH基因突变差异的原... 相似文献
172.
鼻腔鼻窦内翻性乳头状瘤临床分析 总被引:1,自引:0,他引:1
报告鼻腔鼻窦内翻性乳头状瘤21例,男17例,女4例,男女之比为4.25∶1。平均年龄44.8岁,高发年龄组为31~40岁组,占47.6%。最常见的临床症状是鼻阻塞,对单侧鼻腔新生物进行多部位多次活检,可在术前确诊。治疗时整块切除肿瘤和上颌窦内侧壁,可降低术后复发,本组2例经鼻内手术切除肿瘤,19例经鼻侧切开并切除整块肿瘤及上颌窦内侧壁,其中前者1例(50%)复发,后者4例(21.8%)复发,总复发率为23.8%。其中3例发生癌变,其癌变率为14.3%。 相似文献
173.
目的:探讨分化型甲状腺癌(differentiated thyroid carcinoma,DTC)患者手术联合131I治疗后影响预后的相关因素。方法:选择郑州大学第一附属医院经手术联合131I治疗且病理诊断为DTC的235名患者作为研究对象,分析患者性别、首诊年龄、病理类型、中央区淋巴结转移数目、是否合并桥本氏甲状腺炎(hashimoto’s thyroriditis,HT)以及抗甲状腺球蛋白抗体(antithyroglobulin antibody,TgAb)水平动态变化与预后的相关性。结果:DTC患者性别、首诊年龄、病理类型、中央区淋巴结转移数目及TgAb水平均与复发/转移相关,差异有统计学意义(P<0.05),是否合并HT与复发/转移无关(P>0.05)。结论:性别、年龄、病理学类型、中央区淋巴结转移数目、TgAb水平为DTC患者手术联合131I治疗后影响预后的相关因素,在临床预后随访中有重要的指导意义。 相似文献
174.
<正>患者女性,16岁。主因眼前闪光2年余、加重伴头晕5 d,于2013年8月5日入院。2年前无明显诱因出现眼前闪光,呈持续性,未予重视,之后(约2011年1月)于夜间睡眠中出现四肢强直、双眼上翻、口吐白沫和牙关紧闭等症状,偶有舌咬伤情况。发作时神志不清,每次发作约持续数分钟,当 相似文献
176.
慢性阻塞性肺疾病患者呼吸肌力的研究 总被引:6,自引:0,他引:6
目的 研究慢性阻塞性肺疾病(COPD)患者呼吸肌力及中枢驱动性与常规肺功能的关系。方法 对66例COPD患者进行最大吸气压、最大呼气压及口腔阻断压、常规肺功能测定及动脉血气分析。结果 COPD组最大吸气压及最大呼气压明显低于健康组,中枢驱动性明显高于健康组。COPD患者FRC/TLC%、RV%pred、FRC%pred及FEV_1与最大吸气压及中枢驱动性显著相关,其中FRC/TLC%与最大吸气压相关性最好(r=-0.581 P<0.001)。FEV_1和FRC/TLC%与最大呼气压无相关。动脉血氧分压及二氧化碳分压与最大吸气压相关,与最大呼气压及中枢驱动性无相关性。TLC%pred与最大吸气压、最大呼气压及中枢驱动性均无相关性。结论 COPD患者存在呼吸肌功能障碍,肺过度膨胀和气道阻塞是影响COPD患者吸气肌力的重要因素。 相似文献
177.
178.
[目的]了解茌平县消灭脊髓灰质炎防治策略及效果。[方法]描述 1950 年以来脊髓灰质炎发病趋势,分析脊灰疫苗计划免疫各类报表和急性驰缓性麻痹病例监测报表。[结果]随着脊灰疫苗的广泛使用和消灭脊髓灰质炎活动的深入开展,茌平县脊灰发病率逐年下降,1990年以来已无确诊病例发生。主要防治策略是在常规免疫的基础上,开展强化免疫;加强免疫监测和急性驰缓性麻痹病例的监测。[结论]茌平县已连续 14 年无脊灰野病毒的传播,以后应重点消除脊灰疫苗免疫空白[1],进一步提高急性驰缓性麻痹病例监测系统的敏感性。 相似文献
179.
Objective Stimulated thyroglobulin (Tg) levels postablation was associated with disease recurrence in papillary thyroid cancer (PTC). The aim of this study was to evaluate the prognostic value of postoperative stimulated Tg level on future Tg positivity after 131Ⅰ ablation therapy in PTC. Methods One hundred and thirty-eight patients (28 men, 110 women; age range 6-70 years, mean age 39.4 years) with PTC were included in this study. All patients underwent total or near-total thyroidectomy, and 102 of these patients had lymphadenectomy. All patients had a documented PTC. 131Ⅰ ablation was performed in 3- 4 weeks after thyroidectomy. Sera levels of thyroid hormones (FT3, FT4), thyrotropin (TSH), anti-Tg anti-body (TgAb), and Tg were measured before and after 131Ⅰ ablation. Statistical analysis was performed with SPSS 13.0 software, and correlation anaysis and t-test were used. Results Postoperative stimulated Tg lev-el had a significantly positive association with pestablation stimulated Tg level (r = 0. 960, P < 0.01). Postoperative stimulated Tg level in positive postablation Tg group was significantly higher than that in nega-tive pestablation Tg group [(199.8±327.7) μg/L vs (3.5±5.6) μg/L, t =5. 567, P <0.01]. About 76% (78/102) patients had evidence of metastatic cervical lymph nodes on routine histological testing. And 41% (446/1088) resected lymph nodes were histologically positive for metastatic disease. The number of metastatic lymph nodes resected had a significantly positive relationship with stimulated Tg at pestopera-tion and postablation (r = 0. 697, 0. 633, both P < 0.01). Conclusions Postoperative stimulated Tg level was of better prognostic value on stimulated Tg level after 131Ⅰ ablation therapy. Total or near-total thyroidec-tomy simultaneously conjugated with lymphadenectomy might have a better result in lower postablation stimu-lated Tg pesitivity in patients with PTC. 相似文献
180.
Objective To investigate the feasibility of rat sodium/iodide symporter (rNIS) as a reporter gene monitoring rat bone marrow mesenchymal cells (rBMSC) transplanted to rat myocardium in vivo.Methods Recombinated adenovirus vector was constructed by rNIS/enhanced green fluorescence protein (EGFP) (Ad-rNIS/EGFP).rBMSC transfected by Ad-rNIS/EGFP were studied using fluorescence microscope.Fifteen rats were transplanted with rBMSC and randomly divided into three groups:rNIS group (with rNIS transfection), blocked group (with rNIS transfection) by oral intake of perchloric sodium before planar imaging(GE Millennium MPR SPECT), and control group (without rNIS transfection).All rats underwent 99Tcm-pertechnetate planar imaging.The biological distribution of 99Tcm-pertechnetate was studied.The expressions of rNIS gene and protein in myocardium were measured by real time polymerase chain reaction (PCR) and western blot, respectively.The expressions of CD29, CD44, CD90, CD11b, CD34 and CD45 were measured by immunohistochemistry.Results rBMSC transfected by Ad-rNIS/EGFP showed EGFP expression under fluorescence microscope.The transplanted rat myocardium could be visualized on 99Tcm-pertechnetate planar imaging in rNIS group.The relative uptake ratio( Rheart/Rhmb, RUR) was 6.7 ±0.4.RUR in control group (3.0 ±0.2) was lower than that in rNIS group (t =2.78, P=0.03).The percentage injection dose per gram of tissue (% ID/g) of the transplanted myocardium was 60.2 ± 20.8 in rNIS group,which was higher than that (2.5 ± 0.4) % ID/g of control group ( t = 7.13, P<0.001 ).rNIS gene and protein were highly expressed in transplanted myocardium in rNIS group but less expressed in control group.The expressions of CD29, CD44 and CD90 were positive, CD45 and CD45 negative CD11b mildly positive in the myocardium transplanted with infective rBMSC.Conclusion rNIS can efficiently monitor rBMSC transplanted to rat myocardium. 相似文献