ROC曲线评价T细胞亚群、PLT、ESR和CRP在川崎病早期诊断中的应用

目的观察T细胞亚群、血小板计数（PLT）、红细胞沉降率（ESR）和C反应蛋白（CRP）在川崎病（KD）患者中的变化,运用ROC曲线分析它们在KD早期诊断中的价值。方法2008年本院收治的KD患儿33例（实验组）和具有相似体征的非KD患儿34例（对照组）,于入院3d内分别测定T细胞亚群、PLT、ESR和CRP,并观察其ROC曲线特征。结果实验组的CD3＋、CD3＋CD4＋、CD3＋CD8＋测定值分别为：（67.2±9.42）%、（39.0±9.93）%、（24.8±7.42）%;对照组的CD3＋、CD3＋CD4＋、CD3＋CD8＋测定值为：（65.1±12.6）%、（38.2±10.8）%、（24.3±8.42）%,两组之间比较差异无统计学意义（P〈0.05）。实验组的PLT、ESR和CRP测定值分别为：（406.2±167.3）×109/L、56.0（59.5）mm/h、21.0（60.2）mg/L;对照组PLT、ESR和CRP测定值分别为：（284.7±105.9）×10^9/L、12.0（18.75）mm/h、8.0（10.5）mg/L,其差别均具有统计学意义（P〈0.05）。实验组PLT、ESR和CRP的ROC曲线下面积（AUC）分别为：71.2％、89．1％、70．2％；诊断界值分别为：336．5×10^9／L、15．0mm／h、14．5mg／L。结论T细胞亚群在KD早期的变化不明显，其诊断可靠性较低；而PLT、ESR和CRP分别在336．5×10^9／L、15．0mm／h、14．5mg／L时具有较好的诊断效力，能作为KD早期诊断的观察指标。     

钩端螺旋体L型脑动脉炎20例报告

钩端螺旋体Ｌ型脑动脉炎２０例报告马登宏吴国林汤郡朱德明林特夫张郁文刘晓林宋秀宇钩端螺旋体（简称钩体）Ｌ型脑动脉炎系钩体感染后神经系统严重后发症。我院已经实验动物感染证实并在患者体液中培养出钩体Ｌ型。我科于１９９２年２月～１９９３年２月收治２０例患者，...     

钩端螺旋体L型烟雾病一例

钩端螺旋体Ｌ型烟雾病一例马登宏，吴国林，张郁文，宋文英，汤郡，宋秀宇，林持夫患者，男，８岁。发作性右肢抽搐后无力２年，四肢无力５０天入院。患儿于２年前发热，右上肢抽搐。发笑，意识清楚，约半分钟后，右肢无力，数天恢复。此后有类似发作数次，其中有的抽搐发...     

全自动生化分析仪与快速血糖仪测定血糖的比对分析

目的探讨日立7600全自动生化分析仪与快速血糖仪检测血糖结果的相关性及差异性,为临床提供参考。方法应用全自动生化分析仪和快速血糖仪分别对45例患者的血清和末梢血进行测试,测得的数据用SPSS统计学软件进行分析。结果全自动生化分析仪与快速血糖仪测得的血糖值分别(7.27±3.41)mmol/L和(7.87±3.30)mmol/L,快速血糖仪测得值较全自动生化分析仪测得值高,差异有统计学意义(P<0.05)。相关分析表明,二者呈正相关(r=0.91),差异有统计学意义(P<0.001)。结论标本未及时测定是引起血清血糖值假性偏低的主要原因。因此,标本采集后应立即送检,以使结果有较高的准确性。     

不同结核病患者CD4+CD25+Foxp3+调节性T细胞表达的变化

Objective To investigate the expression of CD4 + CD25 + Foxp3 + regulatory T cell in patients with tuberculosis, and to discover its role in the immune response to mycobacterium tuberculosis. Methods Thirty-three patients with tuberculosis and 30 healthy controls were selected who were consulted in our hospital. Patients were classified by their chemotherapy and smear sputum and CD4 + CD25 + Foxp3 + regulatory T cell were detected by flow cytometry. Results Expression of CD4 + CD25high and CD4+ CD25 + Foxp3 + regulatory T cell in experimental group were ( 8.84 ± 2.55 ) % and (6.30 ± 1.38 ) % respectively, which were significantly higher than they were in control group (t = 3.57,4. 01, P ＜ 0. 01 ). The expression of CD4 + CD25high and CD4+ CD25 + Foxp3 + regulatory T cell in patients with positive smear sputum were also significant higher than that in patients with negative smear sputum ( t = 2. 51,2. 42,P ＜ 0.05). No significance was founded between the first-visit group and revisit group ( t = 0. 03, 0. 02, P ＞ 0.05 ). Conclusions CD4 + CD25high and CD4 + CD25 + Foxp3 + regulatory T cell in patients with tuberculosis were higher than healthy control, which may result in immune suppression.     

一例慢性粒细胞白血病骨髓细胞染色体复杂易位

患者男,39岁.因"腰部酸痛10余天,发现白细胞增高1天"住院.查体:体温38.2℃,轻度贫血貌,双侧颈部、腹股沟可扪及3～5个直径约0.5～1.0 cm肿大的淋巴结,胸骨轻压痛;脾肋下8 cm可及.血常规示:白细胞281×109/L,红细胞3.27×1012/L,血红蛋白101 g/L,幼稚细胞40%.血小板496×109/L,幼稚细胞40%.骨髓象提示:慢性粒细胞白血病慢性期.