中西医结合治疗系统性红斑狼疮并发带状疱疹的疗效观察

目的：观察中西医结合治疗系统性红斑狼疮并发带状疱疹的疗效和安全性。方法：选择系统性红斑狼疮并发带状疱疹患者56例,随机分为治疗组和对照组各28例。所有患者在常规治疗SLE的基础上,均给予阿昔洛韦口服;治疗组在上述基础上加用清热凉血解毒中药口服,同时给予氦-氖激光治疗,共治疗2周。结果：2周后,治疗组总有效率、疼痛情况、起疱、止疱时间,疱疹结痂时间等均优于对照组,差异均有统计学意义（P均<0.05）;2组患者均无明显不良反应发生。结论：清热凉血解毒中药配合氦-氖激光照射及阿昔洛韦口服治疗系统性红斑狼疮并发带状疱疹疗效显著且安全性较高,值得临床推广应用。     

类风湿关节炎证候诊断因子优化组合研究

目的：建立类风湿关节炎（RA）证候诊断因子优化组合,实现对RA证候诊断信息进行降维研究的目的。方法：采用聚类分析、Logistic逐步回归分析、逐步判别分析、因子分析等多元统计分析方法,对一组RA临床证候资料进行统计分析。结果：建立了RA证候诊断因子优化组合。结论：RA证候诊断因子优化组合具有较高的诊断价值;将聚类分析、Logistic逐步回归分析、逐步判别分析、因子分析等多元统计分析方法联合应用的证候因子优化组合方法具有很好的降维处理能力。     

Effects of cold-damp and hot-damp environment on VEGF and IL-1 expression in joint cartilage cells in adjuvant arthritis in rats

OBJECTIVE:To study the effects of environmental factors on the degree of injury and expression of vascular endothelial growth factor(VEGF) and interleukin-1(IL-1) in cartilage cells of the joint in a rat model of adjuvant arthritis(AA).METHODS:SD rats aged 10 months were randomly divided into 4 groups that varied by temperature and humidity housing conditions and induction of AA:a control group,a model group,a cold-damp group,and a hot-damp group.All groups except the control group were induced with AA.After 4 w,VEGF and IL-1 expression in cartilage cells of ankle joints of hind limbs were observed.RESULTS:Mean area,optical density,and numbers of VEGF-and IL-1-positive cells in the model group,the cold-damp group,and the hot-damp group were significantly higher than that of the control group(all P<0.05).Optical density and positive cell numbers in the cold-damp group and the hot-damp group were significantly higher than that of the model group(all P<0.05).Optical density and positive cell numbers in the hot-damp group were significantly higher than that of the cold-damp group.Bone in the hot-damp and cold-damp groups was severely injured.CONCLUSION:Environmental factors such as high humidity combined with either high or low temperature increase the severity of damage and expression of VEGF and IL-1 in cartilage cells of joints in rats induced with AA.     

贝赫切特综合征伴上呼吸道出血一例

[病例]男,44岁.主因反复口腔、外阴溃疡20年,鼻出血伴咽喉部出血1个月入院.20天前出现痛性口腔及外阴溃疡,10余天后可自行好转,不久即出现双下肢结节性红斑,压痛明显,双侧大腿、背部、颈部多发性毛囊炎,无眼痛、眼红.诊断为贝赫切特综合征,此后每年均间断发作数次.1个月前无诱因出现鼻出血,就诊于当地医院耳鼻喉科,查咽后壁溃疡、右侧扁桃体溃疡出血,并行全麻下两次右侧扁桃体缝合止血术,术后仍有少量渗血,咳嗽、咯血,并逐渐加重,出血呈鲜红色伴少量血凝块,为进一步诊治转入我院.     

类风湿关节炎诊疗规范

类风湿关节炎(RA)是一种以关节滑膜炎症为主要病理基础的自身免疫病,致残率高。近年来,RA的诊治取得了突飞猛进的发展,国际上有关RA的指南亦不断更新。我国RA患者人数多,规范化诊疗的普及依然欠缺。中华医学会风湿病学分会在借鉴国内外诊治经验和指南的基础上制定了本规范,对RA的诊断、治疗及管理给予建议,以更好地控制关节炎症,改善患者生活质量,减少残疾及疾病负担。     

以血小板升高为主要临床特点的成人斯蒂尔病一例

[病例] 男,67岁.主因四肢肌肉酸痛20天、发热半个月入院.20天前无明显诱因出现四肢肌肉酸痛,以下肢近端肌肉为重,下蹲后起立困难,5天后出现发热,体温最高达39℃,午后为著,可自行下降.     

活血化瘀中药预防云克所致静脉炎效果观察

同位素制剂锝[99Tc]亚甲基二磷酸盐(MDP)注射液(云克)是由中国核动力研究设计院成都同位素应用研究所研制的新药,用于治疗类风湿关节炎、强直性脊柱炎、骨质疏松症、骨关节炎等多种风湿免疫疾病.我们在临床应用中发现,静脉滴注云克所致静脉炎的发生率高达60%[1].这不仅给患者带来一定的痛苦,影响药物疗效,同时也增加了护理人员再次穿刺的难度,对继续治疗造成了一定的困难.为此,我们应用活血化瘀中药预防云克所致静脉炎,取得了一定的疗效,现报告如下.     

益肾健脾、活血利水方药对肾小球系膜细胞增殖及其细胞外基质影响

1实验血清制备:1)中药血清:以仙灵脾、川芎、云苓组成具有益肾健脾、活血利水作用的中药复方,水煎浓缩后,灌饲大耳白兔连续12天,在服最后1剂后2小时心脏采血、分离血清.2)雷公藤多甙血清:以雷公藤多甙片灌饲大耳白兔连续12天,如上法分离血清.3)空白血清:正常饲养,未经任何处理,采取之大耳白兔血清.