DNA content and morphological parameters in synovial sarcoma and synovioma.

By using image analysis technique with 6 normal synovial tissue specimens as controls,nuclear DNA content and morphological parameters in specimens from 51 synovial sarcomas and 15 synovioma were examined quantitatively.The DNA content in synovial sarcoma and synovioma was significantly different (P<0.01), and that of synovioma and normal synovial tissue was also different (P<0.05).Morphological parameters including nuclear areas and perimeters differed significantly among the above three groups(P<0.01).There was no correlation between the DNA content of synovial sarcoma and its histologic type (P>0.05), but the DNA content greatly differed between its higher and lower differentiated grade in each type (P<0.01). The DNA content in synoviai sarcoma IIA stage, according to Enneking's staging system, was lower than that in ⅡB, ⅢA and ⅢB (P<0.05).The 5-year survival rate of synovial sarcoma with diploid/nearly diploid (D/ND) pattern was higher than that of aneuploid (AN) pattern (P=0.028). The study suggests that analysis of the DNA content and morphological parameters of tumor cells is helpful in the diagnosis and pathologic grading of synovial sarcoma.It also provides a guide to clinical operation and estimation of the prognosis. Although synovioma is usually a well-differentiated and benign lesion,this investigation also suggested that increased DNA content may be an indication of poor prognosis for this neoplasm.     

维生素 D_3对大鼠的免疫调节作用研究

观察多次注射维生素 D_3对大鼠的免疫调节作用,结果证明维生素 D_3对抗体产生有双相调节作用,并可增强单核巨噬细胞的分泌功能。连续使用大剂量维生素 D_3可使 T 细胞数量减少。     

人参皂甙单体Rb1对大鼠在体心脏收缩性能的影响

本文作者为进一步探讨人参皂甙单体Rb1对心肌收缩的影响,完善人参对心肌保护作用的系统性研究,拟在在体工作鼠心上,以心肌收缩性能为指标,对比观察Rb1对心肌收缩的影响.     

宫颈鳞癌和食管鳞癌中Fas基因表达及其与放射敏感性的关系

用免疫组化法对 52例宫颈鳞癌和食管鳞癌标本中 Fas基因蛋白进行研究 ,并探讨其与近期放疗效果的关系。结果显示 ,Fas蛋白在宫颈鳞癌和食管鳞癌中表达分别为48.3 8%和 61 .90 % ,Fas蛋白在高分化癌中表达率高于低分化者 ( P<0 .0 5) ,与病期无关 ( P>0 .0 5)。在宫颈鳞癌中 ,Fas蛋白表达高者放疗效果较好 ( P<0 .0 5) ,食管鳞癌 Fas表达与放疗效果无明显相关 ,提示 Fas表达与放射敏感性有一定关系 ,对放疗预后判断有一定价值     

股前外侧阔筋膜瓣联合股外侧肌肌腱瓣移植修复足背软组织缺损

2002年6月至2007年5月,我们应用旋股外侧动脉降支肌皮穿支或肌间隙皮支为血供的股前外侧阔筋膜瓣,联合切取股外侧肌肌腱瓣行吻合血管移植,一期修复足背血管、肌腱与皮肤缺损5例,取得了满意效果.     

微波治疗慢性肥厚性鼻炎96例临床观察

我们自 1998年以来用微波治疗 96例慢性肥厚性鼻炎 ,方法简便 ,效果满意 ,报告如下。1　资料与方法1.1　临床资料　 96例慢性肥厚性鼻炎中男 6 0例 ,女 36例 ,18～ 5 6岁 ,病程 3～ 2 5年 ,临床症状主要是持续性鼻塞 ,粘液性或粘脓性鼻涕多且不易擤出 ,闭塞性鼻音较重 ,失眠 ,记忆力减退 ,精神萎糜及头疼 ,嗅觉显著减退 ,时有耳鸣 ,听力减退 ,泪溢 ,咽干及异物感。检查见下鼻甲黏膜肿胀、肥厚 ,呈淡紫红色 ,表面呈结节状 ,尤以下鼻甲前端及游离缘为重 ,鼻后孔镜有时可见下鼻甲后端呈桑椹状肥厚 ,局部应用麻黄素类药物不能使肿胀明显减退。反…