亚临床型糖尿病性心肌病变的结构与功能改变

对50例无临床心脏病表现的Ⅱ型糖尿病者,用心电图、心音图、颈动脉图及超声心动图等方法进行心脏结构和功能的测定,并与20例正常人对照。结果发现糖尿病组较正常组有心室肥厚、质量增加、收缩功能减退及舒张期顺应性下降等改变。其中合并高血压者影响更大。提示:糖尿病可引起一种功能减退性(收缩力下降,僵硬度增加)肥厚性心肌病变。     

铵梯炸药车间扩建职业危害控制效果评价

某化工厂在 1996年完成铵梯炸药车间改建工程后 ,又于去年进行车间生产线扩建改造。为了全面、正确评估扩建改造后生产环境各作业岗位工人对ＴＮＴ的接触水平 ,预测新ＴＮＴ生产线对接毒工人的健康损害程度 ,综合、客观地评价卫生防护设施的性能、效果和使用情况 ,同时也为该车间的正式投产前的竣工验收提供技术依据 ,我们于2 0 0 2年 4月受该厂委托 ,对该厂生产现场进行劳动卫生监测与作业环境的安全性评价。内容与方法1　采样点的选择　根据 84 #产品生产工艺和生产性有害因素的发生源及其分布情况 ,设立 11个采样点。2　采样数量和时间的…     

心内膜界标法用于定量估价左心室节段运动

目前,虽有若干种方法可用于分析左室造影中左心室壁节段运动,但还无法研究心内膜层某一固定点的运动规律。本文介绍一种左心室造影中的心内膜界标法(Endocardial Landmark),通过研究,初步肯定该方法可用于估价左心室室壁节段活动。方法:动物实验组选用8头猪,平均体重为24公斤,麻醉后经动脉逆行插入带有微型测压器的导管至左心室进行测压与造影,并在左侧位对心室造影作电影摄片。造影毕,换入一特殊导管沿左心室前壁和下后壁分别植入5支带倒钩的尖细金属标记,并作第二次左室造影。上述金属标记便于在左     

远程病理会诊的应用

我院自 1 999年 1 1月始开展远程病理会诊 ,上传会诊病例 34例 ,网上讨论病例 2 6例 ,取得较好效果。1　基层医院病理工作现状目前我区及兵团基层医院病理科的设备落后 ,病理诊断水平较低 ,在职学习提高的机会较少 ,因此 ,在工作中遇到疑难、罕见病例往往难以解决 ,进行远程会诊 ,网上诊断 ,不受时间、地域限制 ,了却了患者原地不动就能请专家教授会诊的梦想。所需费用也仅仅是市内电话费和网络信息费。2　所需设备和通讯线路用现有病理科配备的病理图像分析仪和较经济的普通电话线或综合业务数据网 (ＩＳＤＮ)做为通信线路的连接 ,即可进行…     

模拟调强技术照射鼻咽低分化鳞癌细胞的生物效应机制研究

Objective To study the altered radiobiological effect of simulative intensity-modulated radiotherapy (SIMR) in cultured human nasopharyngeal carcinoma (NPC) cells and the related mechanism. Methods Single cell suspension of exponentially growing CNE-2 cells, a poor differentiated NPC cell line, was seeded and cultured for 12 hours, then the cells were irradiated in two different models by 6 MV X-ray beams at 3 Gy/min. In single fraction irradiation (SFR) model, cells were irradiated a single fraction of 0, 2, 4, 6 or 8 Gy within 0 to 3 minutes. In S1MR model, cells were irradiated 0, 2, 4, 6 or 8 Gy in 5 frac-tions with interval of 8.0-8.5 minutes between. Clonogenic assay was performed to determine the radiosen-sitivity. Cellular apoptosis was measured by flow cytometry. RT-PCR was used to detect mRNA expressions of Bax and Bcl-2, Respectively. Results Compared with SFR group, the survival fraction in SIMR group was higher at all the dose levels. The values of α, β, D0 and Dq were higher in SIMR group than in SFR group. At dose levels of 2 Gy, 4 Gy and 6 Gy, The early and late apoptotic cells in SIMR group were lower than in SFR group (21.20%: 15.89%, F=18.51, P=0.020;13.00%: 10.20, F=15.67, P=0.040).The mRNA expression of Bax was upregulated in a dose-dependent manner in the both groups. Compared with SFR group, the mRNA expression of Bax in SIMR group was lower at all the dose levels (Mean value of 76.75% : 62.50%, F =36.57, P =0.000). Bcl-2 mRNA expression at every dose level had no significant difference between the two groups (Mean value of 29.25% : 29.75%, F=0.74, P=0.800). Conclusions Prolonged delivery time in SIMR model can decrease the radiobiological effects.     

消化道大出血急诊剖腹探查术中内镜的价值

目的 探讨内镜在急性消化道大出血行急诊剖腹探查术中的应用价值.方法 回顾性分析2005年始我科配合急诊手术治疗26例消化道大出血患者的临床资料,评估术中内镜价值.结果 26例均查出出血部位,25例为单一出血灶,1例有2处血管畸形;术中平均内镜检查时间15min.所有患者均根据术中内镜诊断进行了相关手术治疗,术中无死亡病例,术后随访3个月无再出血,1例死于多脏器功能衰竭.结论 对不明原因消化道大出血患者,术中内镜检查是安全有效的手段.     

成人隐睾症腹股沟情况评估与一期行无张力修补术

目的 探讨成人隐睾症术中腹股沟管情况评估的方法及一期无张力修补术的必要性.方法 选取我院收治的成人腹股沟管隐睾186例,年龄18～32岁,分成两组,观察组94例,对照组92例,术中评估腹股沟情况,观察组对内环口扩张及腹横筋膜病例一期进行无张力疝修补术,对照组对单纯内环扩张病例进行单纯疝囊高位结扎术、对腹横筋膜薄弱或内环...     

胃黏膜下囊状淋巴管瘤

患者男,46岁,因反酸、上腹部间断隐痛半年,胃窦隆起病变1 d来我院诊治.患者半年前出现反酸、上腹部间断隐痛,在外院行胃镜检查提示十二指肠球部溃疡,予抑酸等治疗后症状稍有缓解,1 d前在外院复查胃镜提示胃隆起性病变性质待定.体检:腹平软,无压痛及反跳痛,肝脾未触及,腹部未触及异常包块.入院后行胃镜检查:胃窦小弯侧见一处黏膜略隆起,直径约1.8 cm,表面呈淡蓝色,光滑,质软,充气后可变平坦.     

模拟调强技术照射鼻咽低分化鳞癌细胞的生物效应机制研究

Objective To study the altered radiobiological effect of simulative intensity-modulated radiotherapy (SIMR) in cultured human nasopharyngeal carcinoma (NPC) cells and the related mechanism. Methods Single cell suspension of exponentially growing CNE-2 cells, a poor differentiated NPC cell line, was seeded and cultured for 12 hours, then the cells were irradiated in two different models by 6 MV X-ray beams at 3 Gy/min. In single fraction irradiation (SFR) model, cells were irradiated a single fraction of 0, 2, 4, 6 or 8 Gy within 0 to 3 minutes. In S1MR model, cells were irradiated 0, 2, 4, 6 or 8 Gy in 5 frac-tions with interval of 8.0-8.5 minutes between. Clonogenic assay was performed to determine the radiosen-sitivity. Cellular apoptosis was measured by flow cytometry. RT-PCR was used to detect mRNA expressions of Bax and Bcl-2, Respectively. Results Compared with SFR group, the survival fraction in SIMR group was higher at all the dose levels. The values of α, β, D0 and Dq were higher in SIMR group than in SFR group. At dose levels of 2 Gy, 4 Gy and 6 Gy, The early and late apoptotic cells in SIMR group were lower than in SFR group (21.20%: 15.89%, F=18.51, P=0.020;13.00%: 10.20, F=15.67, P=0.040).The mRNA expression of Bax was upregulated in a dose-dependent manner in the both groups. Compared with SFR group, the mRNA expression of Bax in SIMR group was lower at all the dose levels (Mean value of 76.75% : 62.50%, F =36.57, P =0.000). Bcl-2 mRNA expression at every dose level had no significant difference between the two groups (Mean value of 29.25% : 29.75%, F=0.74, P=0.800). Conclusions Prolonged delivery time in SIMR model can decrease the radiobiological effects.     

腹膜透析引起胆囊水肿2例报告

可持续性非卧床式腹膜透析(CAPD)是血液净化疗法的另一种重要技术.由于很少限制饮食、符合人体生理、心血管稳定、利于保护残存肾功能,且安全、操作简单等优点,被广泛用于肾脏替代治疗.笔者在临床工作中遇到2例因腹膜透析引起胆囊水肿,现报道如下.