食管鳞癌组织中VEGF-D表达及其与淋巴管密度和淋巴转移的关系

目的 研究食管鳞状细胞癌(ESCC)组织中血管内皮细胞生长因子D(VEGF-D)的表达情况及其与淋巴管密度(LVD)的关系,并探讨其与食管癌淋巴结转移的关系.方法 免疫组化SABC法检测55例手术切除的食管鳞状细胞癌组织、癌旁组织、正常组织中淋巴管密度和VEGF-D的表达水平,对结果进行统计分析.结果 (1)食管癌组织...     

冠心病肿瘤坏死因子和可溶性肿瘤坏死因子受体活性

本研究旨在通过测定冠心病患者血清肿瘤坏死因子（ＴＮＦα）和可溶性肿瘤坏死因子受体（ＳＴＮＦＲⅡ）以探讨其在冠心病发病中的意义。１对象和方法冠心病患者３０例,男性２４例,女性６例,平均年龄５９．８±１４．０岁;正常对照者３０例,男性２４例,女性６例...     

清心胶囊对病毒性心肌炎不同分期Th细胞分化的影响

目的:观察病毒性心肌炎(VMC)不同分期Th细胞分化的变化以及清心胶囊对这一环节的干预作用。方法:复制VMC急性期和恢复期BALB/c小鼠模型,给予清心较囊治疗后,采用光镜和透射电镜观察心肌病理改变,ELISA法检测血清IFN-γ、IL-2、IL-4和IL-10水平。结果:无论急性期还是恢复期,经清心胶囊治疗后,VMC小鼠心肌病变均明显减轻;VMC小鼠血清中IL-2、IFN-γ水平显著降低(P<0.01,P<0.05),IL-10或IL-4水平显著升高(P<0.05),与正常组比较无显著差异(P>0.05)。结论:清心胶囊能够通过抑制Th1应答,促进Th2应答从而恢复Th1/Th2细胞平衡。     

补阳还五汤合西药治疗急性心肌梗塞30例

急性心肌梗塞为临床常见危重症之一,病死率高.我们2000年1月～2001年11月用补阳还五汤加西药治疗急性心肌梗塞30例,获得较满意效果,现报告如下. 1 资料与方法 1.1 一般资料 59例系住院病例,均有(1)典型的临床表现,(2)特征性心电图改变,(3)血清酶学特异性变化,(4)血清肌钙蛋白T(TnT)或肌钙蛋白I(TnI)测定确诊为急性心肌梗塞(4项中具备2项即可确诊).     

64层螺旋CT冠状动脉成像与心血管疾病危险分层的相关性

Objective To investigate the relationship between the risk stratification of cardiovascular diseases and the outcome of 64-slice helical computed tomography (MSCT) coronary angiography. Methods A total of 470 cases suspected to have coronary heart disease were enrolled.They all received 64-slice MSCT coronary angiography, and they were divided into groups according to the range of disease, degree of calcium scoring, degree of stenosis and characteristic of plaque. Among them, 80 patients underwent both MSCT and selective coronary angiography (CAG) at one time, and they were grouped according to the range of disease and degree of stenosis. All the 470 cases were classified as five levels according to the risk stratification of cardiovascular diseases. The lesions of coronary artery in different risk stratifications were observed, and the correlations were analyzed.Results In the 80 patients who underwent both MSCT and selective CAG, there were no significant differences in the range of coronary artery diseases(χ2=3.631, P=0.067) and coronary arterystenosis (χ2=1.639, P=0.200) between MSCT and CAG. Along with the increased level of the risk stratification, there were the more ranges of the coronary artery diseases (λvery high risk. multi-vessel disease=1.09,λhigh risk. double-vessel disease=0.91, λlow-risk. single-vessel disease=1.07)and the more degrees of coronary artery stenosis(λvery high risk. severe stenosis=0.96,λhigh risk. moderate stenosis=1.03,λlow-risk. mild stenosis=0.78). The degrees of calcium scoring in different risk stratifications of cardiovascular diseases showed significantly differences (F=256.20,123.76,62.50, 98. 24,52.36,P＜0.01). There was the highest percentage of soft plaque in very high risk patients.Higher percentages of fiber plaque, calcified plaque and mixed plaque were found in moderate risk and low risk patients(λvery high risk. soft plaque=1.01,λlow-risk. calcium plaques=1.17). Conclusions The 64-slice MSCT coronary angiography could provide a basis for assessing risk stratification of cardiovascular diseases. The complicated coronary artery disease, moderate-severe calcification, more severe stenosis, higher percentage of soft plaque are found in the very high risk patients. The lower level of the risk stratification is found in patients with the less range of the coronary artery disease and less severe degree of the coronary artery calcification and stenosis. The calcified plaque and mixed plaque are found in moderate risk and low risk patients.     

序贯疗法根除幽门螺杆菌的疗效观察

目的：观察由雷贝拉唑联合阿莫西林、克拉霉素、替硝唑组成的10d序贯疗法根除幽门螺杆菌（Hp）的疗效。方法：将经胃镜检查确诊为慢性活动性胃炎和胃十二指肠溃疡且Hp阳性的患者62例随机分为两组。治疗组方案为前5d雷贝拉唑＋阿莫西林,后5d雷贝拉唑＋克拉霉素＋替硝唑;对照组治疗方案为雷贝拉唑＋阿莫西林＋克拉霉素,疗程10d。结果：治疗组Hp根除率为90．3％,对照组Hp根除率为71．0％,两组间比较差异有统计学意义（P〈0．05）。结论：以雷吼拉唑联合阿莫西林、克拉霉素、替硝唑组成的10d序贯疗法根除Hp具有疗效高、耐受性好等优点。     

有创机械通气治疗老年慢性阻塞性肺疾病并发呼吸衰竭的效果观察及护理

目的 探讨有创机械通气治疗老年慢性阻塞性肺疾病(COPD)并发呼吸衰竭的临床疗效.方法 选择2007年2月至2009年12月我院收治的老年COPD合并呼吸衰竭患者32例,均行经口气管插管机械通气,其中6例因时间过长进行气管切开,观察患者治疗效果及有创机械通气前后血pH值、PaO2和PaCO2的变化情况.结果 本组所有患者脱机成功,好转后转科25例,死亡2例,自动出院5例.与治疗前相比,治疗后患者血气分析明显改善,pH值明显上升,PaO2明显提高,PaCO2明显降低.结论 对于老年COPD并发呼吸衰竭患者,采用有创机械通气在对患者达到有效治疗的同时,还可以明显的改善患者的血气指标,有利于患者的治愈.     

金钠多治疗冠心病心绞痛临床观察

目的 :观察金钠多对冠心病心绞痛的临床疗效。方法 :治疗组和对照组各 3 2例 ,对照组给予一般治疗 ,治疗组在一般治疗基础上加金钠多治疗。结果 :治疗组有显著缓解心绞痛症状 ,总有效率 85 .6% ,血液流变学明显改善 ,优于对照组 (P<0 .0 5 )。结论 :金钠多对冠心病心绞痛有较好的治疗作用     

MCTD伴发结核性多发性浆膜炎一例

患者女性,57岁.因反复发热,胸闷及两下肢浮肿3月,于1990年10月9日收住本院.T38~39℃之间,两下肢踝部浮肿,活动后胸闷气急.曾在当地医院住院2月,经多种抗生素治疗无效.以往有关节疼痛、雷诺氏现象伴腹胀2年,20年前有颈淋巴结结核溃破病史.体检:T38℃,贫血貌,消瘦,巩膜无黄染,全身未及肿大淋巴结.双手皮肤增厚,色素沉着,两肺少量干性罗音,心浊音界向两侧扩大,心音低,心率90次/分,律齐,心尖区Ⅱ     

阿托伐他汀对缺氧致人脐静脉内皮细胞损伤的保护作用

目的观察阿托伐他汀对缺氧导致人脐静脉内皮细胞(HUVECs)损伤的保护作用。方法体外培养HUVECs,建立缺氧模型,采用MTT法测定细胞增殖,透射电子显微镜技术观察细胞的微观结构;检测细胞培养液中LDH、NO、ET-1、Ang-Ⅱ及6-keto-PGF_1α水平。结果阿托伐他汀能够促进缺氧HUVECs的增殖,稳定细胞的微观结构,显著降低细胞内LDH的释放及ET-1的分泌(P<0.01),提高NO、PGI₂的分泌(P<0.01)。结论阿托伐他汀对缺氧导致HUVECs损伤具有明显的保护作用。