老年人自行购药的影响因素及对策

随着老年人认知功能减退和各种心理及生理疾病的增加,严重影响了老年人的生活质量及生命质量。1993年7月第15届国际老年学术大会的主题为科学要为健康的老龄化     

创伤性骨折144例漏诊的影像学分析

外伤患者进行X线检查的目的不仅是为了治疗,一些无需特殊治疗的外伤,影像学检查的目的是为了明确诊断或明确受伤程度,以此维护自己的合法权益。现将我院1997年7月-2001年12月间因各种原因外伤在我院诊治的患者资料进行统计,对其中同一部位作过2次以上X线平片检查,或同一部位既作过X线平片检查又作过CT检查,但检查结论不一致的144例报告如下。     

经皮透光负压旋切术治疗下肢深静脉血栓形成继发皮肤溃疡的临床研究

目的：探讨下肢深静脉血栓形成（DVTS）继发皮肤溃疡的微创治疗方法。方法：选择DVTS继发皮肤溃疡患者116例,其中经皮透光负压旋切术治疗72例72条下肢（A组）,非手术治疗44例44条下肢（B组）。于A组术后5、20、120和360 d（即B组入院后8、23d、出院后97、337 d）记录皮肤的感染率、坏死率、色素减退率、创面收缩率、溃疡愈合率及溃疡复发率等6项临床指标。结果：术后5 d A组皮肤感染率和皮肤坏死率低于B组（P〈0.05）;术后20 d A组创面收缩率与色素减退率较B组显著改善（P〈0.05）;术后120 d A组溃疡愈合率较B组显著升高（P〈0.05）;术后360 d溃疡复发率A组显著低于B组（P〈0.05）。结论：经皮透光负压旋切术治疗DVTS继发皮肤溃疡效果良好,具有微创性、可操作性、可控制性等特点,可作为外科治疗方法之一。     

激光与射频腔内闭合治疗下肢静脉曲张

2004年10月～2006年6月采用激光腔内闭合与射频腔内闭合治疗下肢静脉曲张，取得较好的疗效，报道如下。[第一段]     

放射线联合p53基因及内皮抑素治疗小鼠前列腺癌皮下移植瘤

Objective To test the hypothesis that p53 gene therapy combined with endostatin can enhance tumor response to radiation therapy of RM-1 mouse xenograft prostate cancer and to investigate its mechanism. Methods A mouse prostate cancer model was established. Then mice with xenograft tumor were randomly divided into group A (control), B (radiation), C (radiation and rAdp53), D (radiation and rh-endostatin) and E (radiation and rAdp53 and rh-endostatin). On day 1, rAdp53 was injected intra-tumorously with 1 × 1010 vp per animal to group C and E. From day 1 to 14, rh-endostatin was given 15 mg/kg intraperitoneally daily to group D and E. On day 4 single fraction of 15 Gy was given to tumors in groups B, C, D and E. Normal saline was injected intra-tumorously or intraperitoneaUy accordingly as control. No treatment was done to group A. Tumor volume was measured daily. Samples were collected on Days 5, 10 and 15. Ki67, CD31, p53 and VEGF were detected by means of immunohistochemistry. Results (1) Radiation alone, radiation combined with intra-tumorous injection of Adp53 and/or intraperitoneal injection of rh-endostatin resulted in tumor growth arrest of RM-1 cells in vivo (P = 0.000). Radiation combined with both rAdp53 and rh-endostatin was the most effective treatment (P < 0.05). (2) All the four treatment groups had a decreased expression of mutant type P53 (P = 0.000). The expression of Ki67 in groups B and C were equal (P 0.05) and increasing (P = 0.000), respectively. Group D had a up-down-up curve (P < 0.05), but group E had a up-down one. On day 5 the expresion of VEGF in group E was the lowest (P < 0.05). An increased expression of MVD compared with the control was shown, and MVD in groups C, D and E were always higher than that in the control (P < 0.05). Conclusions The limitation of radiotherapy could be overcome by combination with beth p53 gene therapy and endostatin on the growth of mouse prostate cancer cell. Radiation, rAdp53 and endostatin have their own role but they can be interacted with each other.     

喷雾干燥法制备斑蝥素壳聚糖生物黏附微球的处方工艺研究

摘 要 目的：优选斑蝥素壳聚糖生物黏附微球的最佳处方工艺。方法: 采用喷雾干燥法制备微球,运用单因素试验考察不同壳聚糖分子量对微球胃黏膜黏附率的影响,不同药载比、壳聚糖醋酸溶液浓度和蠕动泵速度对斑蝥素包封率的影响。采用效应面法,以斑蝥素的包封率为考察指标,进一步优化药载比、壳聚糖醋酸溶液浓度和蠕动泵流速3个因素。结果: 斑蝥素壳聚糖生物黏附微球的最佳处方工艺为：斑蝥素和壳聚糖的重量比为19.83%,壳聚糖醋酸溶液浓度为0.77%,蠕动泵流速为9.225 ml·min-1。以最佳处方工艺制得的斑蝥素壳聚糖生物黏附微球包封率为90.14%。结论: 采用喷雾干燥法制备微球,具有工艺稳定、可重复等优点,制备的斑蝥素壳聚糖生物黏附微球具备较好的包封率和生物黏附性能。     

青霉素钠治疗急性痛风性关节炎临床分析

目的： 观察分析青霉素钠治疗急性痛风性关节炎的疗效和机理。方法： 报道３９ 例确诊的急性痛风性关节炎的青霉素纳治疗。结果： 显效１２ 例， 有效１９ 例， 无效８ 例， 总有效率７９－５ ％ 。结论： 青霉素钠是治疗急性痛风性关节炎的有效药物。其药理作用与青霉素的代谢产物抑制了炎症介质的产生和释放有关。     

气相色谱法测定薄荷油中薄荷醇含量

薄荷醇是一种饱和的单环仲萜醇.主要用于牙膏、口香糖、糖果、饮料、化妆品的香料及药品等.本文提出一种较为简便、快捷、准确的气相色谱检测方法,可用于食品、化妆品等日常加工、生产和监督检测工作,获得满意的结果.     

生命体征教学实验课拓展的初步探讨

采用多种教学方法和教学手段,以生命体征教学和实验课为例,在基础护理教学中加以完善和应用。培养学生分析问题和解决问题的能力,使学生具有终身教育的基础和可持续发展的潜能,成为真正的实用型护理人才。