Throat Infection, Neck and Chest Pain and Cardiac Response： A Persistent Infection-Related Clinical Syndrome

Dizziness, chest discomfort, chest depression and dyspnea are a group of symptoms that are common complaints in clinical practice. Patients with these symptoms are usually informed that while neurosis consequent to coronary heart disease is excluded nonetheless they remain unhealthy with no rational explanation or treatment. 165 cases of these symptoms and 85 control subjects were reviewed and underwent further medical history inquiry, routine EKG test and cardiac ultrasound examination. Thirty-five patients received coronary artery angiography to exclude coronary heart disease. Serum myocardial autoantibodies against beta1-adrenoceptor, alpha-myosin heavy chain, M2-muscarinic receptor and adenine-nucleotide translocator were tested, and inflammatory cytokines and high sensitivity C-reaction protein were measured and lymphocyte subclass was assayed by flow cytometry. All patients had a complex of four symptoms or tetralogy： （1） persistent throat or upper respiratory tract infection, （2） neck pain, （3） chest pain and （4） chest depression or dyspnea, some of them with anxiety. Anti-myocardial autoantibodies （AMCAs） were present in all patients vs. 8% in controls. TNF-α, IL-1 and IL-6 were significantly higher in patients than in controls （P〈0.01）. CD3^＋ and CD4-CD8^＋ lymphocytes were significantly higher and CD56＋ lymphocytes lower in patients than those in controls （P〈0.01）. The ratio of serum pathogen antibodies positive against Coxsackie virus-B, cytomegalovirus, Mycoplasma pneumoniae and Chlamydia pneumoniae were all markedly higher in patients. These data led to identification of a persistent respiratory infection-related clinical syndrome, including persistent throat infection, neck spinal lesion, rib cartilage inflammation, symptoms of cardiac depression and dyspnea with or without anxiety.     

电视胸腔镜交感神经切除术的适应证和结果

长期以来胸内交感神经切除术是一种普通的手术,1889年首次开胸切除星状神经节,Kux于1954年用胸腔镜对自主神经系统进行了卓有成效的治疗,进入到现代外科领域。胸腔镜进入临床20年后Jacobaus才首次施行内镜切除胸交感神经段。 交感神经切除术从初期的适应证,如动脉性高血压、心绞痛、支气管哮喘、植物神经张力障碍、癫痫,到治疗突眼、青光眼、视神经和三叉神经痛到目前广泛承认的适应证:治疗掌或腋下多汗症以及周围性动脉血管疾病。胸腔镜交感神经切除术治疗心绞痛和红色恐怖症的可能性还在争论中。     

miR-155和循环系统疾病关系的研究进展

microRNA是一类近年来研究热门的微小RNA分子,在人类多种生理和病理过程中起重要的调节作用,其家族成员miR．155和循环系统疾病关系的研究日益深入而广泛,本文就miR．155和循环系统疾病的诊断、治疗、预后等多方面的关系及其作用机制作一综述。     

巨大胸腺增生一例报道及文献复习

目的探讨巨大胸腺增生(MTH)的临床特点、病理、诊疗方法及预后。方法报道巨大胸腺增生患儿1例,结合文献复习讨论。患儿男,3岁10个月,因活动后乏力2年余入院,胸部CT检查示纵隔及右侧胸腔巨大占位。结果患儿行右侧胸腔巨大肿块切除术。右侧胸腔巨大肿块,约18 cm×16 cm×10 cm,包膜完整。术后病理报告:(右纵隔)胸腺增生病变。术后恢复良好。结论巨大胸腺增生为临床上非常罕见的一种疾病。治疗以手术完整切除为主,预后好。     

锰超氧化物歧化酶与肺癌分期及手术关系的研究

超氧化物歧化酶(SOD)是一种存在于人体内的含金属离子的氧化还原酶,是清除体内有毒的超氧化物阴离子自由基(O_2~(?))的酶,目前已知O_2~(?)和锰超氧化物歧化酶(Mn-SOD)与肿瘤有着十分密切的关系。我们研究Mn-SOD活力与肺癌分期及手术关系,以探讨其可能的临床实用价值。     

带蒂大网膜移植在难治性胸壁结核外科治疗中的应用

目的探讨在难治性胸壁结核手术中带蒂大网膜移植的临床应用及其疗效。方法回顾性分析2008年3月至2009年6月9例难治性胸壁结核患者临床资料,复发6例,巨大病灶3例。采用带蒂大网膜移植填塞残腔并缝合固定,术后持续绷带加压包扎2个月;随访9个月至2年。结果所有患者都一次手术治愈,术后继续抗结核治疗6—12个月,随访无一例复发。结论带蒂大网膜移植用于难治性胸壁结核患者的胸壁重建效果良好,可预防胸壁结核的复发。     

食管神经鞘瘤一例

患者,男,41岁,主诉进行性吞咽困难一年半,活动后胸闷气促1年,入院时可进半流质饮食。体格检查：吸气时偶可闻及哮呜音,颈部淋巴结无肿大。胸部CT：中纵隔内自T1至T4水平可见一椭圆形软组织密度影,食管横径增宽,呈弧形,邻近气管受压明显前移,管腔变窄,考虑为中纵隔肿瘤。     

Association of preoperative serum IGF- I concentration with clinicopathological parameters in patients with non-small cell lung cancer

Insulin-like growth factor-Ⅰ (IGF-Ⅰ) is a mitogenic and anti-apoptotic factor. Serum IGF-I concentration is related to some cancer risk and tumor progression. The aim of this research was to study the association of preoperative serum IGF-Ⅰ concentration with clinicopathological parameters and prognosis of non-small cell lung cancer (NSCLC). Preoperative serum IGF-Ⅰ concentration was measured in 80 consecutive patients with NSCLC who underwent radical lung cancer resection, and 45 patients with benign pulmonary lesion (BPL) by using enzyme linked immunosorbent assay (ELISA). The results showed that the serum IGF-Ⅰ concentration was elevated and correlated with clinicopathological parameters and overall survival (OS) in NSCLC patients. Serum IGF-Ⅰ concentration was significantly higher in patients with NSCLC than in those with BPL. The IGF-Ⅰ concentrations were significantly higher in NSCLC patients with ≥T2, N1-3, and in ⅢA-Ⅳ but not in those with 相似文献   

微创胸骨沉降术治疗鸡胸

目的探讨微创胸骨沉降术治疗鸡胸的方法、技术要点及初步结果。方法应用微创胸骨沉降术治疗鸡胸患者5例,经胸骨前皮下隧道放置Nuss矫形钢板,将胸骨下压,钢板两端通过固定片分别固定于肋骨。结果手术均顺利完成,无围手术期并发症,手术时间( 102.6±23.8)min,失血(14.0±9.7) ml,术后住院时间(6.6±1.6)d。随访4～ 12个月无钢板脱出或移位,全部患者家属对矫治结果满意。 结论微创胸骨沉降术治疗鸡胸是一种简单易行,安全有效的手术方式,值得进一步探索。     

全肺切除术对肺癌患者凝血系统影响的临床研究

目的 观察肺癌患者手术前后凝血指标的变化,探讨全肺切除术对机体凝血系统的影响.方法 采用前瞻性对照研究,选取肺癌患者48例,根据手术方式分为全肺切除组(16例)和肺叶切除组(32例).比较术前及术后1、3、5、7 d的凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)、血小板计数(PLT)、D-二聚体(D-D)及纤维蛋白原(Fib)的变化.结果 全肺切除组和肺叶切除组术前凝血指标比较差异无统计学意义(P＞0.05).术后3 d全肺切除组PT高于肺叶切除组(t=2.345,P=0.023),术后5 d全肺切除组APTT高于肺叶切除组(t=2.456,P=0.017),术后1 d全肺切除组Fib[(5.2±0.6)g/L]与肺叶切除组[(4.4±1.3)g/L]比较,差异有统计学意义(P＜0.01).结论 全肺切除较肺叶切除手术方式更加重肺癌患者的高凝血状态,可能导致血栓栓塞的发生.行抗凝治疗有一定的临床意义.