全文获取类型
收费全文 | 8413篇 |
免费 | 509篇 |
国内免费 | 47篇 |
专业分类
耳鼻咽喉 | 58篇 |
儿科学 | 116篇 |
妇产科学 | 82篇 |
基础医学 | 1472篇 |
口腔科学 | 91篇 |
临床医学 | 982篇 |
内科学 | 2123篇 |
皮肤病学 | 165篇 |
神经病学 | 689篇 |
特种医学 | 279篇 |
外科学 | 1092篇 |
综合类 | 21篇 |
预防医学 | 454篇 |
眼科学 | 93篇 |
药学 | 667篇 |
中国医学 | 14篇 |
肿瘤学 | 571篇 |
出版年
2023年 | 49篇 |
2022年 | 122篇 |
2021年 | 261篇 |
2020年 | 142篇 |
2019年 | 250篇 |
2018年 | 267篇 |
2017年 | 151篇 |
2016年 | 198篇 |
2015年 | 265篇 |
2014年 | 360篇 |
2013年 | 540篇 |
2012年 | 766篇 |
2011年 | 769篇 |
2010年 | 495篇 |
2009年 | 338篇 |
2008年 | 516篇 |
2007年 | 543篇 |
2006年 | 492篇 |
2005年 | 467篇 |
2004年 | 430篇 |
2003年 | 405篇 |
2002年 | 336篇 |
2001年 | 61篇 |
2000年 | 40篇 |
1999年 | 63篇 |
1998年 | 62篇 |
1997年 | 56篇 |
1996年 | 34篇 |
1995年 | 34篇 |
1994年 | 20篇 |
1993年 | 26篇 |
1992年 | 15篇 |
1991年 | 23篇 |
1990年 | 17篇 |
1989年 | 19篇 |
1988年 | 19篇 |
1987年 | 12篇 |
1986年 | 15篇 |
1984年 | 22篇 |
1983年 | 11篇 |
1982年 | 17篇 |
1981年 | 18篇 |
1980年 | 11篇 |
1978年 | 11篇 |
1977年 | 16篇 |
1976年 | 18篇 |
1972年 | 10篇 |
1967年 | 12篇 |
1903年 | 13篇 |
1902年 | 10篇 |
排序方式: 共有8969条查询结果,搜索用时 15 毫秒
991.
992.
Frédéric Janvier Katy Jeannot Sophie Tessé Marjorie Robert-Nicoud Hervé Delacour Christophe Rapp Audrey Mérens 《Antimicrobial agents and chemotherapy》2013,57(7):3408-3411
An NDM-1 carbapenemase-producing Pseudomonas aeruginosa isolate was recovered from a patient hospitalized in France after a previous hospitalization in Serbia. Genetic studies revealed that the blaNDM-1 gene was surrounded by insertion sequence ISAba125 and a truncated bleomycin resistance gene. This blaNDM-1 region was a part of the variable region of a new complex class 1 integron bearing IS common region 1 (ISCR1). The presence of ISPa7 upstream of this integron suggests insertion in a chromosomally located Tn402-like structure. 相似文献
993.
Benoit Witkowski Nimol Khim Pheaktra Chim Saorin Kim Sopheakvatey Ke Nimol Kloeung Sophy Chy Socheat Duong Rithea Leang Pascal Ringwald Arjen M. Dondorp Rupam Tripura Fran?oise Benoit-Vical Antoine Berry Olivier Gorgette Frédéric Ariey Jean-Christophe Barale Odile Mercereau-Puijalon Didier Menard 《Antimicrobial agents and chemotherapy》2013,57(2):914-923
The declining efficacy of artemisinin derivatives against Plasmodium falciparum in western Cambodia is a major concern. The knowledge gap in the understanding of the mechanisms involved hampers designing monitoring tools. Here, we culture-adapted 20 isolates from Pailin and Ratanakiri (areas of artemisinin resistance and susceptibility in western and eastern Cambodia, respectively) and studied their in vitro response to dihydroartemisinin. No significant difference between the two sets of isolates was observed in the classical isotopic test. However, a 6-h pulse exposure to 700 nM dihydroartemisinin (ring-stage survival assay -RSA]) revealed a clear-cut geographic dichotomy. The survival rate of exposed ring-stage parasites (ring stages) was 17-fold higher in isolates from Pailin (median, 13.5%) than in those from Ratanakiri (median, 0.8%), while exposed mature stages were equally and highly susceptible (0.6% and 0.7%, respectively). Ring stages survived drug exposure by cell cycle arrest and resumed growth upon drug withdrawal. The reduced susceptibility to artemisinin in Pailin appears to be associated with an altered in vitro phenotype of ring stages from Pailin in the RSA. 相似文献
994.
BÉATRICE BREMBILLA‐PERROT M.D. ANNE M. ZINSCH M.D. JEAN M. SELLAL M.D. PIERRE Y. ZINZIUS M.D. JÉRÔME SCHWARTZ M.D. DANIEL BEURRIER M.D. CHRISTIAN DE CHILLOU M.D. JEAN P. GODENIR M.D. JEAN P. LETHOR M.D. CÉCILE MARCHAL M.D. JEAN L. CLOEZ M.D. MAHESHWAR PAURIAH M.D. RADU NOSU M.D. MARIUS ANDRONACHE M.D. FRANÇOIS MARÇON M.D. 《Pacing and clinical electrophysiology : PACE》2013,36(7):803-810
995.
JUAN LEAL DEL OJO M.D. RICARDO PAVÓN M.D. DOLORES GARCÍA M.D. JAVIER QUINTANA M.D. JORGE CAPARRÓS M.D. DAVID VILLAGOMEZ M.D. MARIA VAZQUEZ M.D. JOSÉ MIGUEL BARQUERO M.D. LUIS PASTOR M.D. 《Pacing and clinical electrophysiology : PACE》2013,36(2):e38-e40
We describe a 72‐year‐old man referred for implantation of a cardiac resynchronization therapy device who had previously undergone repeated operations to replace the mitral valve. Retrograde venography of the coronary sinus (CS) to implant the left ventricular (LV) pacing lead revealed aneurysmal dilatation of the CS with LV‐CS fistula that hindered—but did not prevent—complete implantation of the system. (PACE 2013; 36:e38–e40) 相似文献
996.
FERNANDO CABRERA BUENO M.D. Ph.D. JAVIER ALZUETA RODRÍGUEZ M.D. Ph.D. JOSÉ OLAGÜE DE ROS M.D. IGNACIO FERNÁNDEZ‐LOZANO M.D. Ph.D. JUAN JOSÉ GARCÍA GUERRERO M.D. JOAQUÍN FERNÁNDEZ DE LA CONCHA M.D. ANTONIO HERNÁNDEZ MADRID Ph.D. JOSE MARÍA TOLOSANA VIU M.D. JOAQUÍN OSCA ASENSI M.D. ALBERTO BARRERA CORDERO M.D. Ph.D. ELENA LLORENTE HERNANGÓMEZ 《Pacing and clinical electrophysiology : PACE》2013,36(8):963-969
997.
Marie Hokayem Emilie Blond Hubert Vidal Karen Lambert Emmanuelle Meugnier Christine Feillet-Coudray Charles Coudray Sandra Pesenti Cedric Luyton Stéphanie Lambert-Porcheron Valerie Sauvinet Christine Fedou Jean-Frédéric Brun Jennifer Rieusset Catherine Bisbal Ariane Sultan Jacques Mercier Joelle Goudable Anne-Marie Dupuy Jean-Paul Cristol Martine Laville Antoine Avignon 《Diabetes care》2013,36(6):1454-1461
OBJECTIVE
To assess the clinical efficacy of nutritional amounts of grape polyphenols (PPs) in counteracting the metabolic alterations of high-fructose diet, including oxidative stress and insulin resistance (IR), in healthy volunteers with high metabolic risk.RESEARCH DESIGN AND METHODS
Thirty-eight healthy overweight/obese first-degree relatives of type 2 diabetic patients (18 men and 20 women) were randomized in a double-blind controlled trial between a grape PP (2 g/day) and a placebo (PCB) group. Subjects were investigated at baseline and after 8 and 9 weeks of supplementation, the last 6 days of which they all received 3 g/kg fat-free mass/day of fructose. The primary end point was the protective effect of grape PPs on fructose-induced IR.RESULTS
In the PCB group, fructose induced 1) a 20% decrease in hepatic insulin sensitivity index (P < 0.05) and an 11% decrease in glucose infusion rate (P < 0.05) as evaluated during a two-step hyperinsulinemic-euglycemic clamp, 2) an increase in systemic (urinary F2-isoprostanes) and muscle (thiobarbituric acid–reactive substances and protein carbonylation) oxidative stress (P < 0.05), and 3) a downregulation of mitochondrial genes and decreased mitochondrial respiration (P < 0.05). All the deleterious effects of fructose were fully blunted by grape PP supplementation. Antioxidative defenses, inflammatory markers, and main adipokines were affected neither by fructose nor by grape PPs.CONCLUSIONS
A natural mixture of grape PPs at nutritional doses efficiently prevents fructose-induced oxidative stress and IR. The current interest in grape PP ingredients and products by the global food and nutrition industries could well make them a stepping-stone of preventive nutrition.The Western diet, dominated by ultra-processed products rich in saturated fats and sugar, including high-fructose corn syrup, and poor in micronutrients (1), is a major contributor to the worldwide “diabesity” epidemic. In addition to contributing to calorie overconsumption, the unique metabolism of fructose (2) and its marked effect on systemic oxidative stress (3) could give it a pivotal role in the pathophysiology of insulin resistance (IR) and the metabolic syndrome (4).The “French Paradox,” defined as a low incidence of coronary heart disease despite consumption of a diet rich in saturated fat (5), has stimulated interest in investigating whether grape polyphenols (PPs) may offer antioxidant-consequential health benefits (6–8) including improved insulin sensitivity (9), although this effect remains debated (10). If this outcome were to be confirmed in humans, then supplementation of highly processed foods with grape PPs may prove to be a promising strategy to stem the tide of chronic metabolic diseases, which, furthermore, would be quite easy to implement, since PPs are currently marketed in the form of dyes and tannins that can be used safely in relatively large amounts in sugary foods (11).We thus designed a randomized double-blinded controlled study to assess the clinical efficacy of nutritional amounts of grape PPs in counteracting the metabolic effects of high-fructose diet (HFrD) to substantiate the hypothesis that by neutralizing oxidative stress, grape PPs can prevent fructose-induced IR. 相似文献998.
999.
1000.