全文获取类型
收费全文 | 401篇 |
免费 | 31篇 |
专业分类
儿科学 | 17篇 |
妇产科学 | 1篇 |
基础医学 | 28篇 |
口腔科学 | 5篇 |
临床医学 | 24篇 |
内科学 | 224篇 |
皮肤病学 | 3篇 |
神经病学 | 13篇 |
特种医学 | 6篇 |
外科学 | 66篇 |
综合类 | 2篇 |
预防医学 | 18篇 |
眼科学 | 1篇 |
药学 | 13篇 |
肿瘤学 | 11篇 |
出版年
2024年 | 1篇 |
2023年 | 3篇 |
2022年 | 8篇 |
2021年 | 25篇 |
2020年 | 7篇 |
2019年 | 12篇 |
2018年 | 19篇 |
2017年 | 8篇 |
2016年 | 16篇 |
2015年 | 10篇 |
2014年 | 14篇 |
2013年 | 19篇 |
2012年 | 24篇 |
2011年 | 29篇 |
2010年 | 16篇 |
2009年 | 19篇 |
2008年 | 32篇 |
2007年 | 19篇 |
2006年 | 20篇 |
2005年 | 31篇 |
2004年 | 24篇 |
2003年 | 23篇 |
2002年 | 17篇 |
2001年 | 4篇 |
2000年 | 4篇 |
1999年 | 7篇 |
1998年 | 9篇 |
1997年 | 5篇 |
1996年 | 4篇 |
1994年 | 1篇 |
1992年 | 1篇 |
1985年 | 1篇 |
排序方式: 共有432条查询结果,搜索用时 15 毫秒
31.
We present 2 new cases of pasteurella multocida induced peritonitis in patients on long term CCPD. We also briefly review the literature on a total of 16 cases (including the present 2 cases) reported in the English literature. 相似文献
32.
BACKGROUND: The National Kidney Foundation has recently published the Kidney Disease Outcomes Quality Initiative (K/DOQI) Clinical Practice Guidelines for Bone Metabolism and Disease in Chronic Kidney Disease (CKD). According to these guidelines, in patients with stage 5 CKD, the adjusted calcium level should be 8.4- 9.5 mg/dl, the serum phosphate should be 3.5-5.5 mg/dl, the calcium phosphorous product should be <55 mg(2)/dl(2) and the intact parathyroid hormone (PTH) level should be 150-300 pg/ml. METHODS: In order to evaluate our ability to meet these targets, we reviewed laboratory parameters of bone and mineral metabolism of 140 patients over a 6-month period in an inner city hemodialysis unit. Serum calcium and phosphate levels were determined using standard assays and PTH levels were determined using the Nichols Intact PTH assay. RESULTS: We found that the levels of serum calcium and serum phosphorus fell within the range recommended by the K/DOQI guidelines 49 and 36% of the time respectively. 57% of the determinations for calcium x phosphorus product were <55 mg(2)/dl(2). PTH levels were within the recommended values in 20% of the determinations. Only 7% of the determinations met all four criteria simultaneously in spite of meeting other K/DOQI targets such as hematocrit and dialysis adequacy. CONCLUSION: These data indicate that current practice for the management of bone and mineral metabolism in hemodialysis falls far short of meeting the K/DOQI guidelines. 相似文献
33.
Acute hemodynamic benefit of multisite ventricular pacing after congenital heart surgery 总被引:9,自引:0,他引:9
Zimmerman FJ Starr JP Koenig PR Smith P Hijazi ZM Bacha EA 《The Annals of thoracic surgery》2003,75(6):403-1780
BACKGROUND: Cardiac dysfunction after congenital heart surgery is a major cause of morbidity and mortality. Cardiac resynchronization through multisite ventricular pacing (MSVP) improves cardiac index and ventricular function, and lowers systemic vascular resistance (SVR) in adults with heart failure and interventricular conduction delay. METHODS: The acute hemodynamic effects of MSVP after congenital heart surgery were assessed. Twenty-nine patients (aged 1 week to 17 years) with prolonged QRS interval had atrial and ventricular unipolar epicardial temporary pacing leads placed at surgery. Group 1 consisted of patients with a single ventricle (n = 14); group 2 included patients with two-ventricle anatomy (tetralogy of Fallot, ventricular septal defect) undergoing ventricular surgery (n = 10); and group 3 included patients with two-ventricle anatomy undergoing other cardiac surgery (n = 5). At a mean postoperative day 1 (range, 0 to 6), blood pressure, systemic and mixed venous oxygen saturations, electrocardiograms, and echocardiograms were obtained before and after 20 minutes of MSVP. RESULTS: The QRS duration decreased with MSVP in all patients (mean, 23%, p < 0.005). Systolic blood pressure improved in all patients (mean, 9.7%, p < 0.005). Cardiac index improved in 19 of 21 patients tested, with no change in 2 patients (mean, 15.1%, p = 0.0001). In 2 patients, MSVP facilitated weaning from cardiopulmonary bypass. Echocardiographic mitral or tricuspid valve inflow was not significantly different with MSVP. CONCLUSIONS: Multisite ventricular pacing results in improved cardiac index and increased systolic blood pressure, and it can also facilitate weaning from cardiopulmonary bypass. Multisite ventricular pacing may be used as adjunct to standard postoperative treatment of cardiac dysfunction after congenital heart surgery. 相似文献
34.
Ziyad Ben Ahmed Mohamed Yousfi Johan Viaene Bieke Dejaegher Kristiaan Demeyer Debby Mangelings 《Pharmaceutical biology》2017,55(1):1185-1194
Context: The widespread use of Pistacia atlantica Desf. ssp. (Anacardiaceae) in traditional medicine can be partly attributed to the content of its secondary metabolites, in particular, the phenolic compounds.Objective: The effects of harvest period, growing region and gender on the phenolic compounds, flavonoids and condensed tannins contents were studied, as well as on the antioxidant activities of P. atlantica leaves in order to provide a scientific basis for optimal collection.Materials and methods: Leaves were collected monthly from April to October 2010 in two Algerian sites. The powdered leaves were used for preparing the ethyl acetate extract. Contents of total phenolics (TPC), flavonoids (FC) and condensed tannins (CTC) were determined spectrophotometrically. Antioxidant activity was evaluated through radical scavenging activity (RSA) of 2,2-diphenyl-1-picrylhydrazyl (250?μM) and the reducing power capacity (RPC) determination by K3Fe(CN)6 (1%).Results: The TPC was found to vary from 79?±?13 to 259?±?8?mg gallic acid equivalents/g of dry weight (DW) during the study period. The RSA and RPC varied between 262?±?18 and 675?±?21?mg Ascorbic Acid Equivalent (AAE)/g DW, and from 259?±?16 to 983?±?20?mg AAE/g DW, respectively. A seasonal pattern was observed consisting of a decrease in TPC content and RPC from spring to autumn. The FC, CTC and RSA did not show a seasonal pattern.Discussion and conclusion: Our findings showed that secondary metabolite content and antioxidant activities of P. atlantica leaves were more influenced by harvest time and growing region than by gender. 相似文献
35.
Habib RR Yassin N Ghanawi J Haddad P Mahfoud Z 《Zeitschrift fur Gesundheitswissenschaften》2011,19(2):171-182
Purpose
This study analyzed associations between war-related internal displacement, housing quality and the prevalence of chronic illness in Nabaa, a low-income neighborhood on the outskirts of Beirut, Lebanon. 相似文献36.
Ziyad Mahfoud Rana Emam Dana Anchassi Setarah Omran Najlaa Alhaj Samya Al-Abdulla 《Women & health》2019,59(6):631-645
Premenstrual dysphoric disorder (PMDD) is not well-studied in Arab populations. The goal of this study was to validate the Arabic version of the Premenstrual Symptoms Screening Tool (PSST) using the DSM diagnosis of PMDD as the gold standard. The PSST was translated and culturally adapted using back translation and the approval of the original author. We recruited 194 adult women (between October 2013 and March 2014) from two primary care centers in Doha, Qatar. A psychiatrist determined the diagnosis using the semi-structured Mini International Neuropsychiatric Interview, and another rater blinded to the diagnosis finalized the Arabic PSST and administered other clinical questionnaires. The data showed that premenstrual symptoms and PMDD were observed in about 37 percent and 15 percent, respectively, of the women enrolled. The mean age of the women with PMDD according to the PSST was about 30 years, and the majority had children. The Arabic PSST showed high specificity of 95.6 percent but low sensitivity of 26.7 percent. A factor analysis of the different items in Arabic PSST showed that the Arabic PSST could detect the cases with definite PMDD and thus can be a useful tool in primary care settings as this treatable disorder is underdiagnosed in the Arab populations. 相似文献
37.
Cristian Bersezio Javier Martín Carla Mayer Oriana Rivera Juan Estay Rolando Vernal Ziyad S. Haidar Pablo Angel Osmir B. OliveiraJr. Eduardo Fernández 《Quality of life research》2018,27(12):3199-3207
Purpose
Intracoronary bleaching is a minimally invasive, alternative treatment that addresses aesthetic concerns related to non-vital teeth discoloration. However, to the best of our knowledge, no studies have assessed the psychosocial impacts of such procedures on patients’ aesthetic perceptions. The aim of this study was to evaluate aesthetic perceptions and the psychosocial impact of patients up to 3 months after their teeth had been bleached with hydrogen peroxide (35%) and carbamide peroxide (37%) using the walking bleach technique.Methods
The patients were randomly divided into two groups according to the bleaching agent used: G1?=?hydrogen peroxide 35% (n?=?25) and G2?=?carbamide peroxide 37% (n?=?25). Non-vital bleaching was performed in four sessions. Color was objectively (ΔE) and subjectively (ΔSGU) evaluated. Aesthetic perception and psychosocial factors were evaluated before, 1 week and 1 month after the bleaching using the Oral Health Impact Profile (OHIP) and Psychosocial Impact of Dental Aesthetics Questionnaire (PIDAQ) questionnaires.Results
The color change (ΔE) values at 1 month were G1?=?16.80?±?6.07 and G2?=?14.09?±?4.83. These values remained stable until the third month after treatment (p?>?0.05). There was a decrease in the values of OHIP-aesthetics and PIDAQ after treatment versus baseline (p?<?0.05). This status was maintained through the third month after treatment.Conclusions
Both agents were highly effective and had a positive impact on the aesthetic perception and psychosocial impact of patients, values that also remained stable over time. Non-vital bleaching yields positive and stable impacts on aesthetic perception and psychosocial factors. ClinicalTrials.gov identifier NCT02718183.38.
39.
Yan Xie Benjamin Bowe Yan Yan Miao Cai Ziyad Al-Aly 《Mayo Clinic proceedings. Mayo Clinic》2021,96(1):92-104
ObjectiveTo estimate the contribution of county-level contextual factors to differences in life expectancy in the United States.MethodsWe used a counterfactual approach to estimate the years of life expectancy lost associated with 45 potentially modifiable county-level contextual characteristics in the United States in the year 2016. Contextual data and life expectancy data were obtained from the County Health Ranking Project and the U.S. Small-Area Life Expectancy Estimates Project, respectively.ResultsMedian census-tract–level life expectancy was 78.90 (interquartile range, 76.30-81.00) years, and the range across census tracts spanned 41.20 years. Large variations in life expectancy existed within and between states and within and between counties; the gap between counties was 20.30 years and gaps within counties ranged from 0 to 34.60 years. An array of 45 county-level factors was associated with 4.30 years of life expectancy loss. County-level adult smoking, food insecurity, adult obesity, physical inactivity, college education, and median household income were associated with 1.24-, 0.89-, 0.58-, 0.35-, 0.33-, and 0.14-year losses in life expectancy, respectively; and altogether were associated with a 3.53-year loss in life expectancy. The contribution of contextual factors to years of life expectancy lost varied among states and was more pronounced in states with lower life expectancy and in areas of increased socioeconomic deprivation and increased percentage of Black race.ConclusionSubstantial geographic variation in life expectancy was observed. Six county-level contextual factors were associated with a 3.53-year loss in life expectancy. The findings may inform and help prioritize approaches to reduce inequalities in life expectancy in the United States. 相似文献
40.