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Miran Aswad Mahmoud Rayan Saleh Abu-Lafi Mizied Falah Jamal Raiyn Ziyad Abdallah Anwar Rayan 《Inflammation research》2018,67(1):67-75
Objectives
The aim was to index natural products for less expensive preventive or curative anti-inflammatory therapeutic drugs.Materials
A set of 441 anti-inflammatory drugs representing the active domain and 2892 natural products representing the inactive domain was used to construct a predictive model for bioactivity-indexing purposes.Method
The model for indexing the natural products for potential anti-inflammatory activity was constructed using the iterative stochastic elimination algorithm (ISE). ISE is capable of differentiating between active and inactive anti-inflammatory molecules.Results
By applying the prediction model to a mix set of (active/inactive) substances, we managed to capture 38% of the anti-inflammatory drugs in the top 1% of the screened set of chemicals, yielding enrichment factor of 38. Ten natural products that scored highly as potential anti-inflammatory drug candidates are disclosed. Searching the PubMed revealed that only three molecules (Moupinamide, Capsaicin, and Hypaphorine) out of the ten were tested and reported as anti-inflammatory. The other seven phytochemicals await evaluation for their anti-inflammatory activity in wet lab.Conclusion
The proposed anti-inflammatory model can be utilized for the virtual screening of large chemical databases and for indexing natural products for potential anti-inflammatory activity.54.
Saad Althuwaini Fahad Bamehriz Abdullah Aldohayan Waleed Alshammari Saleh Alhaidar Mazen Alotaibi Abdullah Alanazi Hossam Alsahabi Majid Abdularahman Almadi 《Obesity surgery》2018,28(4):916-922
Background and Aims
Laparoscopic sleeve gastrectomy (LSG) might be associated with a new onset or worsening of gastroesophageal reflux disease (GERD). We aim to evaluate the prevalence of post-LSG GERD symptoms and its predictors.Methods
We included patients who underwent primary LSG at a university hospital from 2009 to 2015. We used the GERD-Health-Related Quality of Life (GERD-HRQL) questionnaire and included questions regarding regurgitation to evaluate symptoms before and after LSG; each item was scored from 1 to 5 based on the symptom severity.Results
A total of 213 patients (mean age, 36.08 ± 10.22 years; 48.36% were men) were included. The mean preoperative body mass index (BMI) was 47.84 kg/m2, mean percent total weight loss was 37.99% (95% CI, 36.64 to 39.34), mean percent excess weight loss was 84.14% (95% CI, 80.91 to 87.36), and the mean percent excess BMI loss was 84.17% (95% CI, 80.94 to 87.41). The mean heartburn score while standing increased (0.71 vs. 1.09, p < 0.01) as well as the score of heartburn requiring a diet change (0.67 vs. 1.16, p < 0.01) post-LSG. The scores for dysphagia, odynophagia, and regurgitation increased. New-onset heartburn was reported in 47.06% of our cohort. Those with high preoperative BMIs were less likely to develop new-onset or worsening symptoms of GERD (odds ratio [OR], 0.97; 95% confidence interval [CI], 0.95–0.99). More severe heartburn symptoms while standing were associated with higher risks of developing or worsening GERD symptoms (OR, 1.22; 95% CI, 1.01–1.47). None of the other variables could predict the development or worsening of the GERD symptoms.Conclusion
Symptoms of heartburn and regurgitation are common after LSG; however, none of the variables preoperatively could strongly predict patients who would develop new onset or experience worsening of symptoms postoperatively.55.
Yan Xie Benjamin Bowe Yan Yan Miao Cai Ziyad Al-Aly 《Mayo Clinic proceedings. Mayo Clinic》2021,96(1):92-104
ObjectiveTo estimate the contribution of county-level contextual factors to differences in life expectancy in the United States.MethodsWe used a counterfactual approach to estimate the years of life expectancy lost associated with 45 potentially modifiable county-level contextual characteristics in the United States in the year 2016. Contextual data and life expectancy data were obtained from the County Health Ranking Project and the U.S. Small-Area Life Expectancy Estimates Project, respectively.ResultsMedian census-tract–level life expectancy was 78.90 (interquartile range, 76.30-81.00) years, and the range across census tracts spanned 41.20 years. Large variations in life expectancy existed within and between states and within and between counties; the gap between counties was 20.30 years and gaps within counties ranged from 0 to 34.60 years. An array of 45 county-level factors was associated with 4.30 years of life expectancy loss. County-level adult smoking, food insecurity, adult obesity, physical inactivity, college education, and median household income were associated with 1.24-, 0.89-, 0.58-, 0.35-, 0.33-, and 0.14-year losses in life expectancy, respectively; and altogether were associated with a 3.53-year loss in life expectancy. The contribution of contextual factors to years of life expectancy lost varied among states and was more pronounced in states with lower life expectancy and in areas of increased socioeconomic deprivation and increased percentage of Black race.ConclusionSubstantial geographic variation in life expectancy was observed. Six county-level contextual factors were associated with a 3.53-year loss in life expectancy. The findings may inform and help prioritize approaches to reduce inequalities in life expectancy in the United States. 相似文献
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Ziyad Mahfoud Rana Emam Dana Anchassi Setarah Omran Najlaa Alhaj Samya Al-Abdulla 《Women & health》2019,59(6):631-645
Premenstrual dysphoric disorder (PMDD) is not well-studied in Arab populations. The goal of this study was to validate the Arabic version of the Premenstrual Symptoms Screening Tool (PSST) using the DSM diagnosis of PMDD as the gold standard. The PSST was translated and culturally adapted using back translation and the approval of the original author. We recruited 194 adult women (between October 2013 and March 2014) from two primary care centers in Doha, Qatar. A psychiatrist determined the diagnosis using the semi-structured Mini International Neuropsychiatric Interview, and another rater blinded to the diagnosis finalized the Arabic PSST and administered other clinical questionnaires. The data showed that premenstrual symptoms and PMDD were observed in about 37 percent and 15 percent, respectively, of the women enrolled. The mean age of the women with PMDD according to the PSST was about 30 years, and the majority had children. The Arabic PSST showed high specificity of 95.6 percent but low sensitivity of 26.7 percent. A factor analysis of the different items in Arabic PSST showed that the Arabic PSST could detect the cases with definite PMDD and thus can be a useful tool in primary care settings as this treatable disorder is underdiagnosed in the Arab populations. 相似文献
57.
Imad Edward Shehadi Sameer I. Shehadi Ramzi R. Shehadi Ayman N. Tawil Saad A. Dibo Ziyad R. Mahfoud 《European journal of plastic surgery》2010,33(6):361-367
Random flaps have been supplanted by more immediate and reliable reconstructive methods because the former require two or
more procedures and a period of delay. This study was designed to test the hypothesis that a random flap can be elevated,
delayed, and safely divided within 4 days. Ninety-two Sprague–Dawley rats were operated by elevating an 8 cm × 4 cm cranially
based dorsal flap with its underlying panniculus carnosus muscle. The rats were divided into four groups, one control and
three experimental, with 23 rats in each. In the control group, the flap was elevated and its caudal end divided at the same
time without delay. In the experimental groups, we tested three delay procedures and all flaps had their caudal end divided
4 days after elevation. The number of flaps showing total viability compared to the flaps showing any amount of necrosis was
as follows: control group 1:22, mini delay group 18:5, progressive craniocaudal elevation group 19:4, and the accelerated
delay group 22:1. The extent of necrosis, expressed as mean percentage area of necrosis in each group, was as follows: control
group 45.9%, in the mini delay group 2.3%, progressive craniocaudal elevation group 2.5%, and the accelerated delay group
0.1%. Delay of this random flap can be accomplished safely in 4 days. In terms of total flap survival and mean percentage
necrosis, all three experimental delay procedures were effective in improving total viability and reducing the extent of necrosis
significantly. We believe the observed difference in total viability and mean percentage necrosis in the accelerated delay
group to be clinically significant. 相似文献
58.
Howard C. Herrmann MD FACC FSCAI Sandra Baxter PhD Carlos E. Ruiz MD PhD FACC FSCAI Ted E. Feldman MD FACC FSCAI Ziyad M. Hijazi MD FACC FSCAI 《Catheterization and cardiovascular interventions》2010,76(4):E106-E110
Background: Minimal information is available on the number and type of procedures being performed for structural and valvular heart disease, the physicians who perform these procedures, and on the training requirements for this emerging field. Methods: Surveys were performed using an online survey of members of the Society of Cardiac Angiography and Interventions (SCAI), including its Council on Structural Heart Disease and the Congenital Heart Disease Committee. The responses of 107 US‐based interventional cardiologists were analyzed. A second questionnaire of a purposive sample of 10 training directors of US interventional cardiology programs was also performed. Results: Although many procedures (e.g., transseptal puncture, PFO, and ASD closure) are commonly performed by most respondents, others are limited to a significant minority of respondents (e.g., alcohol septal ablation, transcatheter valve repair, and implantation). In addition, the number of procedures performed varies greatly as does the training directors' estimate of the number necessary to gain proficiency. There is no single method being used to gain the requisite skills. A number of factors that limit the more widespread growth of this field were identified. Conclusions: The field of intervention for structural and valvular heart disease is new, growing rapidly, and will require a core knowledge base and new didactic methods. The cardiovascular community will be challenged to devise new training standards and credentialing approaches to serve interventionalists interested in this field. © 2010 Wiley‐Liss, Inc. 相似文献
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Kyoko Kaku Masaaki Takeuchi Lissa Sugeng Joseph A. Lodato Hiromi Nakai Lynn Weinert Kyoko Otani Hidetoshi Yoshitani Nobuhiko Haruki Ziyad M. Hijazi Yutaka Otsuji Roberto M. Lang 《Journal of Echocardiography》2009,7(3):48-54