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171.
抗心律失常新药关附甲素血浆浓度测定的方法 总被引:1,自引:0,他引:1
抗心律失常新药关附甲素(Guan—fu base A)与三氟醋酐反应,迅速定量地生成双-三氟乙酸酯衍生物,其结构经GC-MSD的分析得到证实。关附甲素衍生物经气相色谱分离后,在电子捕获检测器上有较高的响应,线性范围宽(10~2.0×104ng/ml,r=0.9984)。血中平均回收率为97.52%。本法以烯丙洛尔(alprenolol)为内标,定量准确,日内及日间差的变异系数分别小于7%和9%,并已成功地用于关附甲素临床前的药代动力学研究。 相似文献
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CONSUELO TALÉNS MERCEDES ANDRÉS MARISA REBAGLIATO 《Child: care, health and development》1987,13(2):101-109
The psychomotor development achieved by two girls with the Aicardi syndrome is described. Until now this syndrome has been considered to produce a total dissociation from the environment in those affected. The results of early intervention, although not spectacular, are sufficient to recommend early stimulation in these children. 相似文献
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BM El‐Zawahry DA Bassiouny A Khella NS Zaki 《Journal of the European Academy of Dermatology and Venereology》2010,24(3):264-269
Background The effectiveness of Diphencyprone (DPC) in alopecia areata (AA) was demonstrated in several studies with highly variable response rates ranging from 5% to 85%. Objective The response rate and variable factors affecting the prognosis were studied focusing on long‐term follow‐up with or without maintenance therapy. Methods A total of 135 cases of AA were treated with DPC. Patients were divided into five groups according to the area of scalp affected: Grade 1 AA: 25–49% scalp affection; Grade 2 AA: 50–74% scalp affection; Grade 3 AA: 75–99% scalp affection; alopecia totalis and alopecia universalis. An initial response was defined as appearance of new terminal hair within treated sites. Excellent response was defined as terminal hair covering >75% of the scalp. Relapse meant >25% hair loss. Maintenance therapy meant ongoing therapy once every 1–4 weeks after excellent response. Follow‐up was performed to detect any relapse of AA. Results Ninety‐seven patients continued therapy for ≥3 months. After an initial 3 month lag, cumulative excellent response was seen in 15 patients (15.4%), 47 patients (48.5%), 51 patients (52.6%) and 55 patients (55.7%) after 6, 12, 18 and 24 months respectively in a mean median time of 12 months. The only patient variable affecting the prognosis was baseline extent of AA. Excellent response was seen in 100%, 77%, 54%, 50% and 41% in Grade 1, Grade 2, Grade 3, AA totalis and AA universalis patients respectively. Side‐effects were few and tolerable. Hair fall >25% occurred in 17.9% of patients on maintenance and 57.1% of patients without maintenance therapy (P‐value = 0.025). Conclusion Diphencyprone is an effective and safe treatment of extensive AA. A long period of therapy is needed and will increase the percentage of responders especially in alopecia totalis and universalis. Maintenance therapy is recommended to reduce the risk of relapse. 相似文献