第四军医大学口腔医学博物馆在教学中的应用

第四军医大学口腔医院口腔医学博物馆成立于2010年,面积539 m2,馆内共有13个展区,收藏和展出头颅、牙颌系统化石、口腔器械、教具、书籍等实物4 500余套件。博物馆为口腔医学发展史的研究提供了丰富的资料,为口腔医学的传承、教育和发展起到了积极的推动作用。     

两种根管充填糊剂充填效果的比较

目的比较两种根管充填糊剂充填治疗牙髓坏死和慢性根尖周病的临床疗效。方法将164例患者共198颗患牙随机分为治疗组和对照组,治疗组采用Cortisomol糊剂加牙胶尖侧压行一次性根管充填;对照组用氧化锌糊剂加牙胶尖侧压根管充填,观察两组术后疗效。结果两组疗效比较差异有非常显著性,治疗组优于对照组。结论Cortisomol糊剂一次性根管充填疗法能减轻疼痛,疗效满意。     

The effects of gradually induced backward movement of the mandible by a Twin Inclined Plane Device in rats

Abstract Objective: To develop a model of gradually induced backward movement of the mandible under normal masticatory action and to examine morphological changes in the mandible and condylar cartilage in rats. Materials and Methods: The newly developed Twin Inclined Plane Device (TIPD) was composed of upper and lower posterior metal crowns with a long inclined plane on both sides separately and was applied in experimental groups of 6-week-old male Wister rats. After 3, 14, 30, and 60?days, the rats were euthanatized and samples were collected. Various measurements and hematoxylin-and-eosin stains were performed. Results: From day 30 on, the length of the condylar process was shorter in the TIPD groups than in the control groups (P < .05). The angulation of the condylar process axis to the mandibular plane was greater in the TIPD groups (P < .01). The thickness of the condylar cartilage in the posterior part of the posterior region was thinner in the TIPD groups (P < .05) on day 30 and even thinner (P < .01) on day 60; from day 30 on, the thickness in the anterior part of the posterior region was thicker in the TIPD groups (P < .01). Conclusion: TIPD can successfully induce backward movement of the mandible under normal masticatory action. TIPD can cause region-specific changes in condylar cartilage and leads to a continuous remodeling.     

显脉香茶菜化学成分的研究

在继续对显脉香茶菜Ｒａｂｄｏｓｉａ ｎｅｒｖｏｓａ （Ｈｅｍｓｌ）Ｃ．Ｙ．Ｗｕ ｅｔ Ｈ．Ｗ．Ｌｉ茎叶有效成分的研究中,又分得一种新的对映－甲壳杉烷型二萜,经理化常数和波谱分析,确定其结构为１α、１５β－二羟基－６β－乙氧基－６,７－Ｂ－断裂－对映－贝壳杉－１６－烯－６,２０－环氧－７,２０－内酯,命名为显脉香茶菜丙素（ｒａｂｄｏｎｅｒｖｏｓｉｎＣ）。     

巩膜外硅压联合玻璃体切割术治疗人工晶状体或无晶状体眼视网膜脱离

目的:探讨在治疗人工晶状体或无晶状体眼视网膜脱离中巩膜硅压联合玻璃体切割术比单纯巩膜硅压手术的优越性。方法:回顾性分析30例我院联合手术治疗的人工晶状体或无晶状体眼视网膜脱离患者的临床资料。各位患者均采用巩膜外硅压联合玻璃体切割手术修复脱离的视网膜,术后随诊3～14mo,对手术后的解剖复位、视力提高情况以及并发症进行考察。结果:所有患者(30眼)均1次手术复位成功并有不同程度的视力提高,没有发现任何玻璃体切割手术的并发症。结论:在治疗人工晶状体或无晶状体眼视网膜脱离中,巩膜外硅压联合玻璃体切割术比单纯巩膜硅压手术有明显的优越性,其成功率的提高与玻璃体切割术提高周边视网膜的可见度,以及减少PVR的发生相关。     

Comparison of corneal flap thickness between primary eyes and fellow eyes using the Zyoptix XP microkeratome

PURPOSE: To evaluate corneal flap thickness created in myopic laser in situ keratomileusis (LASIK) using the Zyoptix XP 120 microkeratome (Bausch & Lomb). SETTING: University-based eye clinic. METHODS: Corneal thickness was measured preoperatively and intraoperatively after flap creation in 62 consecutive patients (124 eyes) who had LASIK for the correction of myopia. Corneal flap thickness was calculated by subtracting stromal bed thickness from total corneal thickness. In each patient, both corneas (right followed by left) were cut by 1 the same Zyoptix XP 120 microkeratome blade at the same session. RESULTS: The mean actual flap thickness was 115.34 microm +/- 16.34 (SD) in right eyes and 104.55 +/- 14.34 mum in left eyes. The mean actual flap thickness in right eyes was not statistically significantly different from the 120 microm proposed by the manufacturer (P = .142); however, the mean actual flap thickness in left eyes was statistically significantly different from the 120 microm (P<.001). The mean flap thickness in the second eye was also statistically significantly thinner than in the first eye (P<.001). CONCLUSIONS: The corneal flaps were thinner than expected when a Zyoptix XP 120 microkeratome was used in LASIK. Although the first cuts produced thinner flaps, this difference was not statistically significant. However, the second cuts produced significantly thinner flaps.     

颈动脉海绵窦瘘的影像学诊断

目的探讨超声、CT及MRI检查对颈动脉海绵窦瘘诊断的意义。方法对1997至2004年临床资料完整并行超声、CT及MRI检查的58例颈动脉海绵窦瘘患者进行回顾性分析,详细观察B超、彩色多普勒超声、CT及MRI检查结果,总结颈动脉海绵窦瘘的影像学表现以资诊断。结果颈动脉海绵窦瘘的影像学表现主要包括眼上静脉扩张、海绵窦膨大、眼球突出及眼外肌增粗。眼上静脉扩张是颈动脉海绵窦瘘最具特异性的影像学征象,分别为：B超发现51例,呈管状无回声腔,有与心脏同步的搏动;彩色多普勒发现49例,显示眼上静脉内充满反向流动的动脉化血流;CT检查发现58例,显示扩张的眼上静脉呈从前内向后外的梭形血管影;MRI检查发现眼上静脉扩张58例,信号特征为在T1WI和T2WI均为流空的无信号血管影。海绵窦膨大是另一特异性征象,分别为：CT检查发现41例,显示膨大的海绵窦呈高密度影;MRI发现37例海绵窦膨大,显示在T1WI和T2WI上均呈流空的无信号影。结论颈动脉海绵窦瘘具有独特的影像学表现,B超、彩色多普勒、CT及MRI检查均能清晰呈现,并且对颈动脉海绵窦瘘的临床诊断和鉴别诊断有重要意义。     

多西环素对体外培养的人视网膜色素上皮细胞移行的抑制作用

目的探讨基质金属蛋白酶抑制剂多西环素对体外培养并经转化生长因子（TGF）-β1刺激的人视网膜色素上皮（RPE）细胞迁移的影响。方法对3～6代培养的人RPE细胞,用不同浓度（0．01、0,10、1．00、10．00μg／L）TGF-β1处理36h,采用明胶酶谱分析法检测人RPE细胞上清液中明胶酶的活性,采用Boyden室迁移测定法评估RPE细胞经TGF-β1刺激后的迁移情况。结果TGF-β1能促进人RPE细胞中基质金属蛋白酶一2的分泌,并具有浓度依赖性。在无多西环素的环境下,TGF-β1刺激RPE细胞后,能明显促进RPE细胞迁移,迁移的RPE细胞数约增加27％,与对照组相比差异有统计学意义（P〈0．01）。在多西环素的环境中,TGF-β1刺激人RPE细胞后迁移受到明显抑制,随着多西环素浓度的增加,RPE细胞穿透微小多孔膜发生迁移的细胞数相应减少,迁移的RPE细胞数约减少50％～70％,与对照组相比差异有统计学意义（P〈0．01）。结论多西环素能抑制TGF-β1作用所致的RPE细胞迁移,TGF-β1介导的基质金属蛋白酶-2活性的增加在RPE细胞的迁移中起重要作用。