独居老年人常见心理问题的社区干预评价

目的探讨适宜的丰十区干预措施对独居老年人心理健康的作用。方法采用“症状自评量表（SCL-90）”、“抑邯自评量表（SDS）”和自制问卷调查表。对老西门社区418名≥60岁独居老人作心理健康水平问卷调查，什展“生理-心理-社会”综合干预并进行效果评价。结果经过干预。研究对象的SDS评分和情绪低落、抑郁及焦虑的发生率均较干预前下降，差异有统计学意义（P＜0．01）。结论社区全科医学综合干预刘改善独居老人心理健康水平。提高其生活质量是行之有效的。     

The role of Rho/ROCK in epileptic seizure-related neuronal damage

Metabolic Brain Disease - Epilepsy is one of the most severe neurological disorders characterized by spontaneous recurrent seizures. Although more than...     

颅内压监测下重度颅脑外伤伴双侧瞳孔散大的手术治疗

目的探讨重度颅脑外伤致双瞳散大的手术治疗方法 ,并观察其临床结局。方法 38例重度颅脑外伤伴双瞳散大患者行颅内压探头置入侧脑室伴双侧脑室外引流术后,再行血肿清除+双侧大骨瓣去除术+硬膜减张修补术。结果 38例患者中死亡17例,恢复良好5例,中度残疾9例,重度残疾7例。生存患者颅内压在术后4 d升至高峰,随后逐步下降,死亡患者术后颅内压持续升高,且各组颅内压在不同时间点均差异显著(P0.05或P0.01)。结论重症颅脑外伤伴双瞳散大患者病情危重,积极行外科手术治疗可取得一定疗效,动态监测颅内压可帮助判定预后。     

芫根提取液抗疲劳作用的实验研究

【摘要】 目的 探讨高原作物芫根提取液的抗疲劳作用。方法 选用雄性ICR小鼠作为实验动物,采用随机分组的方法将小鼠分为芫根组、红景天组和空白对照组3组,每组各24只。芫根组小鼠通过灌胃法使其连续摄入芫根提取液,红景天组小鼠灌胃等量的红景天口服液,空白对照组小鼠以同样的方法灌胃灭菌去离子水,3组均持续灌胃14天,每天1次。分别在灌胃第7天和第14天测定小鼠的力竭游泳时间、全血血糖水平、血清乳酸水平和血清乳酸脱氢酶活性。取小鼠小肠组织提取mRNA并测序,测序结果进行差异表达分析,同时通过相关分析预测软件预测对与乳酸脱氢酶（LDH）的主要亚基LDHA相互作用的基因。 结果 芫根组和红景天组小鼠的血糖水平在灌胃第7天和第14天均无明显变化（P＞0.05）。与空白对照组相比,芫根组和红景天组小鼠的力竭游泳时间在灌胃第7天无明显差异（P＞0.05）,在灌胃第14天均显著延长（P＜0.01）,但芫根组与红景天组小鼠之间的力竭游泳时间比较差异无统计学意义（P＞0.05）。与空白对照组比较,芫根组小鼠的血清乳酸水平在灌胃第7天和第14天均显著降低（P＜0.01）;而红景天组小鼠的血清乳酸水平仅在灌胃第14天才出现显著降低（P＜0.01）;芫根组小鼠的血清乳酸水平在灌胃第7天明显低于红景天组（P＜0.05）,但在灌胃第14天两组比较无明显差异（P＞0.05）。与空白对照组相比,芫根组和红景天组小鼠的血清乳酸脱氢酶活性在灌胃第7天升高（P＜0.05）,在灌胃第14天显著升高（P＜0.01）。芫根组与空白对照组相比,差异表达基因中HIF1A 和ABCC9的表达水平呈显著上调（P＜0.05）,而编码LDH关键亚基LDHA的基因在芫根组中表达下调,但差异无统计学意义（P＞0.05）。分析转录组测序结果后,预测了五个与乳酸脱氢酶A（LDHA）相互作用的基因。结论 芫根提取液具有提高血清乳酸脱氢酶活性、降低小鼠血清乳酸含量的作用,但对小鼠血糖水平无影响;芫根对乳酸脱氢酶的表达量和活性的影响可能是分别通过HIF1A和ABCC9实现的;长期服用芫根提取液可通过提高血清乳酸脱氢酶活性而加快血清乳酸的清除,从而达到与红景天相似的抗疲劳效果。     

铁死亡在高血压发病中的作用

铁死亡是一种新发现的铁依赖性的细胞程序性死亡方式,主要特征为细胞内铁超载、谷胱甘肽耗竭及脂质过氧化。高血压是心脑血管疾病发生的重要危险因素之一,越来越多的研究证明高血压与铁死亡密切相关。本文将综述铁死亡与高血压之间的联系,以及铁死亡影响高血压的相关可能机制,以期为高血压的治疗提供新的思路。     

PCSK9在多囊卵巢综合征卵巢颗粒细胞中的表达研究

目的 研究前蛋白转化酶枯草溶菌素9(PCSK9)在多囊卵巢综合征(PCOS)卵巢颗粒细胞中的表达情况,并探讨PCSK9表达与PCOS卵巢组织以及睾酮处理的KGN细胞中脂质状况的关系.方法 通过来曲唑联合高脂饲料喂养构建PCOS大鼠模型,油红O染色观察PCOS大鼠卵巢组织中脂质分布情况;生物信息学分析筛选PCOS卵巢与正...     

Effect of stem cell treatment on burn wounds: A systemic review and a meta‐analysis

A meta‐analysis was performed to evaluate the effect of stem cells treatment in managing burn wounds. A systematic literature search up to March 2022 incorporated 24 studies reported between 2013 and 2021 including 400 animals with burn wounds at the beginning of the study; 211 were using stem cells treatment, and 189 controlled. Statistical tools like the contentious method were used within a random or fixed‐influence model to establish the mean difference (MD) with 95% confidence intervals (CIs) to evaluate the influence of stem cells treatment in managing burn wounds. Stem cells treatment had a significantly higher burn wound healing rate (MD, 15.18; 95% CI, 11.29‐19.07, P < .001), higher blood vessel number (MD, 12.28; 95% CI, 10.06‐14.51, P < .001), higher vascular endothelial growth factor (MD, 10.24; 95% CI, 7.19‐13.29, P < .001), lower interleukin‐1 level (MD, −98.48; 95% CI, −155.33 to −41.63, P < .001), and lower tumour necrosis factor α level (MD, −28.71; 95% CI, −46.65 to −10.76, P < .002) compared with control in animals'' models with burn wounds. Stem cells treatment had a significantly higher burn wound healing rate, higher blood vessel number, higher vascular endothelial growth factor, lower interleukin‐1 level, and lower tumour necrosis factor α level compared with control in animals'' models with burn wounds. Further studies are required to validate these findings.     

Study on Influencing Factors of Ground Pressure Behavior in Roadway-Concentrated Areas under Super-Thick Nappe

During the mining activity under the super-thick nappe formed by thrust fault, the law of mine pressure behavior is complex, and it is difficult to control the deformation and failure of surrounding rock. Combined with the actual engineering conditions, the influence of different roof lithology conditions, the thickness of nappe, the mining height, the size of the barrier coal pillar, and the creep time on mine pressure behavior was studied by UDEC numerical simulation software. The results showed that with the advancement of the coal face, due to the influence of the mining of the coal face and the slip dislocation of the super-thick nappe along the thrust faults, the roof-to-floor convergence, the two-sided convergence, and the maximum concentrated stress in the roadway-concentrated areas are significantly increased. For the above five influencing factors, the greater the thickness of the nappe and the mining height, the longer the creep time, and the stronger the ground pressure behavior. The larger the size of the barrier coal pillar, the stronger the roof lithology, and the gentler the ground pressure behavior. The research results can provide some reference for monitoring the law of ground pressure behavior in roadway-concentrated areas under super-thick nappe.     

基于数据挖掘探究针灸治疗阿片类毒品稽延性戒断综合征的选穴规律

目的：采用数据挖掘技术探究针灸治疗阿片类毒品稽延性戒断综合征（POAS）的用穴规律。方法：通过检索中英文数据库收集有关治疗POAS的针灸临床文献，建立其处方数据库，采用SPSS 21.0对其进行描述性分析和聚类分析，采用SPSS Modeler18.0对其进行关联规则分析，探究针灸治疗POAS的腧穴运用特点及其规律。结果：对纳入的36篇文献进行分析，结果显示：针灸治疗POAS最常用的干预措施为电针；所选腧穴以特定穴为主体，注重上下配穴；腧穴配伍存在固定搭配，经穴置信度最高的关联群为足三里-内关；通过聚类分析可得到4个聚类群。结论：通过数据挖掘技术发现针灸治疗POAS存在一定规律，特定穴是处方的主要组成部分，足三里-三阴交-神门-内关为针灸治疗POAS的主要腧穴。