经尿道双极等离子前列腺剜除术与电切术治疗良性前列腺增生症的效果比较

目的：探讨经尿道双极等离子前列腺剜除术与前列腺电切术治疗良性前列腺增生症的的临床效果。方法选取2012年5月~2014年3月来本院就诊的良性前列腺增生症患者100例,随机分为经尿道双极等离子前列腺剜除术组（剜除组）及经尿道双极等离子前列腺电切术组（电切组）各50例。观察两组手术时间、术中出血量等指标,记录术前、术后3个月国际前列腺症状评分（IPSS）、生活质量（QOL）评分、最大尿流率（Qmax）及并发症。结果剜除组手术时间、术中出血量、膀胱冲洗时间、尿管留置时间、术后住院时间均短于电切组（P<0.05）。两组术后3个月IPSS、QOL评分明显低于治疗前,Qmax明显增高,尤以剜除组效果为佳;且剜除组并发症率也较低（P<0.05）。结论经尿道双极等离子前列腺剜除术治疗良性前列腺增生症的临床效果显著,值得临床推广应用。     

速效救心丸对比硝酸甘油治疗心绞痛急性发作疗效和安全性的系统评价

目的系统评价速效救心丸对比硝酸甘油治疗心绞痛急性发作的疗效和安全性。方法计算机检索PubMed、EMbase、Web of SCI、the Cochrane Library、中国知网(CNKI)、维普中文科技期刊全文数据库(VIP)、万方数据资源系统(WanFang Data)、中国生物医学文献服务系统(SinoMed)等数据库,纳入速效救心丸对比硝酸甘油治疗心绞痛急性发作的随机对照试验(RCT),检索时限均为建库至2019年10月30日。由两位评价者独立筛选文献、提取资料和评价纳入研究的偏倚风险后,采用RevMan 5.3软件进行Meta分析。结果纳入6项RCT,共651例心绞痛急性发作病人。Meta分析结果显示,试验组不良反应发生率低于对照组[RR=0.37,95%CI(0.20,0.69),P=0.002];两组心绞痛改善率[RR=1.00,95%CI(0.94,1.06),P=0.97]和心电图改善率[RR=0.94,95%CI(0.84,1.05),P=0.26]差异均无统计学意义。结论当前证据表明,舌下含服速效救心丸或硝酸甘油片在心绞痛急性发作的治疗方面疗效均较好,但速效救心丸不良反应更少,安全性好。     

Synthesis,Biological Evaluation,and Docking of Dihydropyrazole Sulfonamide Containing 2‐hydroxyphenyl Moiety: A Series of Novel MMP‐2 Inhibitors

In this study, we synthesized a series of dihydropyrazole sulfonamide derivatives containing 2‐hydroxyphenyl moiety as antitumor agents to target the matrix metalloproteinase‐2 (MMP‐2). All of the synthesized compounds were examined by bioactivity assays, in which compound 4c turned out as a potential antagonist of MMP‐2 along with potent anticancer activity against four tumor cell lines. Structure–activity relationship analysis was also performed to examine how structural changes impacted the bioactivity. Suggested to be caused by the induction of apoptosis, the antitumor mechanism of 4c was further confirmed by PI combining with annexin V‐FITC staining assay using flow cytometry analysis. These new findings along with molecular docking observations suggested that compound 4c could be developed as a potential anticancer agent.     

Development of a new ferulic acid certified reference material for use in clinical chemistry and pharmaceutical analysis

This study compares the results of three certified methods, namely differential scanning calorimetry (DSC), the mass balance (MB) method and coulometric titrimetry (CT), in the purity assessment of ferulic acid certified reference material (CRM). Purity and expanded uncertainty as determined by the three methods were respectively 99.81%, 0.16%; 99.79%, 0.16%; and 99.81%, 0.26% with, in all cases, a coverage factor (k) of 2 (P=95%). The purity results are consistent indicating that the combination of DSC, the MB method and CT provides a confident assessment of the purity of suitable CRMs like ferulic acid.Abbreviations: ASTM, American Society for Testing and Materials; CRM, certified reference material; CT, coulometric titrimetry; DAD, diode-array detector; DSC, differential scanning calorimetry; EDQM, European Directorate for Quality Medicine; GUM, Guide to the Expression of Uncertainty in Measurement; ISO, International Organization for Standardization; MB, mass balance; RM, reference material; SI, International System of Units; WHO, World Health OrganizationKEY WORDS: Differential scanning  calorimetry, Mass balance, Coulometric titrimetry, Certified reference  material, Uncertainty, Ferulic acid     

人工智能技术在MSCT肺结节诊断中的应用

人工智能(artificial intelligence,AI)是当前科学技术发展中的一门前沿学科[1],被定义为精准医疗的典范,其强大的后处理能力和进一步学习、分析能力逐渐得到业界的认可,它广泛应用于医学领域,在临床医学影像诊断中、特别是在肺部小结节的诊断应用已日渐增多,但临床应用方面的有关报道仍较少。近年来,我院在肺部小结节、冠状动脉血管成像以及颅内血肿诊断等方面的MSCT影像诊断也在不断尝试应用。相信在不久的将来,以人工智能技术为主导的新潮流[2],必将为医学影像诊断带来新机遇。本文有关肺部结节MSCT应用的认识进行分析,供同道参考。     

Superhydrophobic engineering materials provide a rapid and simple route for highly efficient self-driven crude oil spill cleanup

Traditional superhydrophobic material use depends on two processes: creating a rough structure on a material surface and modifying the rough surface with low surface energy materials. However, common preparation methods are time-consuming, complex and cost-ineffective. Furthermore, these methods usually rely on chemicals, and evidently that will restrict mass preparation and application of superhydrophobic materials. This study reports a simple polypropylene (PP) solution-based process for producing PP hierarchical structures on commercial copper mesh (low surface energy materials), without modifying the low surface energy materials. The hierarchical structures of copper meshes, surface modified with PP, can be rationally controlled by optimizing the PP concentration. The obtained copper mesh showed contact and rolling off angles of 162° and 7°, respectively. Importantly, no significant performance loss was observed after the superhydrophobic copper meshes were continuously and drastically rinsed with 3.5 wt% NaCl solution, or repeated tearing with an adhesive tape for more than 30 cycles, indicating its good durability. After surface modification with PP particles, the copper mesh exhibits both excellent superhydrophobicity and superoleophilicity. Additionally, the as-prepared copper mesh can self-float on water surface when deformed into a “miniature boat” shape. Meanwhile, self-driven spilled oil cleanup was achieved using a superhydrophobic copper mesh-formed miniature boat. The miniature boat can realize energy conservation as well as high efficiency. The cleanup rate of the boat is as high as 97.1%, demonstrating its great potential in environmental remediation applications.

Traditional superhydrophobic material use depends on two processes: creating a rough structure on a material surface and modifying the rough surface with low surface energy materials.